Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/17777 |
Resumo: | p. 18-22 |
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Mendes, Dayana SantosDantas, Marina LoyolaGomes, Juliana MenezesSantos, Washington Luis Conrado dosSilva, Adriano QueirozGuimarães, Luiz HenriqueMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deArruda, Sérgio MarcosMendes, Dayana SantosDantas, Marina LoyolaGomes, Juliana MenezesSantos, Washington Luis Conrado dosSilva, Adriano QueirozGuimarães, Luiz HenriqueMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deArruda, Sérgio Marcos2015-05-28T14:28:14Z2015-05-28T14:28:14Z20130074-0276http://repositorio.ufba.br/ri/handle/ri/17777v. 108, n. 1p. 18-22Disseminated leishmaniasis (DL) differs from other clinical forms of the disease due to the presence of many non-ulcerated lesions (papules and nodules) in non-contiguous areas of the body. We describe the histopathology of DL non-ulcerated lesions and the presence of CD4-, CD20-, CD68-, CD31- and von Willebrand factor (vW)-positive cells in the inflamed area. We analysed eighteen biopsies from non-ulcerated lesions and quantified the inflamed areas and the expression of CD4, CD20, CD68, CD31 and vW using Image-Pro software (Media Cybernetics). Diffuse lymphoplasmacytic perivascular infiltrates were found in dermal skin. Inflammation was observed in 3-73% of the total biopsy area and showed a significant linear correlation with the number of vW+ vessels. The most common cells were CD68+ macrophages, CD20+ B-cells and CD4+ T-cells. A significant linear correlation between CD4+ and CD20+ cells and the size of the inflamed area was also found. Our findings show chronic inflammation in all DL non-ulcerated lesions predominantly formed by macrophages, plasmacytes and T and B-cells. As the inflamed area expanded, the number of granulomas and extent of the vascular framework increased. Thus, we demonstrate that vessels may have an important role in the clinical evolution of DL lesions.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2015-03-09T13:43:24Z No. of bitstreams: 1 Dayana Santos Mendes.pdf: 980956 bytes, checksum: 74c31c8fcc57fd5951687750890e1e4b (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-05-28T14:28:14Z (GMT) No. of bitstreams: 1 Dayana Santos Mendes.pdf: 980956 bytes, checksum: 74c31c8fcc57fd5951687750890e1e4b (MD5)Made available in DSpace on 2015-05-28T14:28:14Z (GMT). No. of bitstreams: 1 Dayana Santos Mendes.pdf: 980956 bytes, checksum: 74c31c8fcc57fd5951687750890e1e4b (MD5) Previous issue date: 2013http://dx.doi.org/10.1590/S0074-02762013000100003reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBADisseminated leishmaniasisHistopathologyImmunohistochemistryInflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasisMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALDayana Santos Mendes.pdfDayana Santos Mendes.pdfapplication/pdf980956https://repositorio.ufba.br/bitstream/ri/17777/1/Dayana%20Santos%20Mendes.pdf74c31c8fcc57fd5951687750890e1e4bMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17777/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTDayana Santos Mendes.pdf.txtDayana Santos Mendes.pdf.txtExtracted texttext/plain21722https://repositorio.ufba.br/bitstream/ri/17777/3/Dayana%20Santos%20Mendes.pdf.txt3f510a710d4cd53f8d81fb49e991dae2MD53ri/177772022-07-05 14:03:35.518oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:35Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis |
| dc.title.alternative.pt_BR.fl_str_mv |
Memórias do Instituto Oswaldo Cruz |
| title |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis |
| spellingShingle |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis Mendes, Dayana Santos Disseminated leishmaniasis Histopathology Immunohistochemistry |
| title_short |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis |
| title_full |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis |
| title_fullStr |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis |
| title_full_unstemmed |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis |
| title_sort |
Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis |
| author |
Mendes, Dayana Santos |
| author_facet |
Mendes, Dayana Santos Dantas, Marina Loyola Gomes, Juliana Menezes Santos, Washington Luis Conrado dos Silva, Adriano Queiroz Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Carvalho Filho, Edgar Marcelino de Arruda, Sérgio Marcos |
| author_role |
author |
| author2 |
Dantas, Marina Loyola Gomes, Juliana Menezes Santos, Washington Luis Conrado dos Silva, Adriano Queiroz Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Carvalho Filho, Edgar Marcelino de Arruda, Sérgio Marcos |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mendes, Dayana Santos Dantas, Marina Loyola Gomes, Juliana Menezes Santos, Washington Luis Conrado dos Silva, Adriano Queiroz Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Carvalho Filho, Edgar Marcelino de Arruda, Sérgio Marcos Mendes, Dayana Santos Dantas, Marina Loyola Gomes, Juliana Menezes Santos, Washington Luis Conrado dos Silva, Adriano Queiroz Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Carvalho Filho, Edgar Marcelino de Arruda, Sérgio Marcos |
| dc.subject.por.fl_str_mv |
Disseminated leishmaniasis Histopathology Immunohistochemistry |
| topic |
Disseminated leishmaniasis Histopathology Immunohistochemistry |
| description |
p. 18-22 |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
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2015-05-28T14:28:14Z |
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2015-05-28T14:28:14Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://repositorio.ufba.br/ri/handle/ri/17777 |
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0074-0276 |
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v. 108, n. 1 |
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0074-0276 v. 108, n. 1 |
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http://repositorio.ufba.br/ri/handle/ri/17777 |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1590/S0074-02762013000100003 |
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