The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages

Detalhes bibliográficos
Autor(a) principal: Gomes, Ivana Nunes
Data de Publicação: 2009
Outros Autores: Palma, I. C., Campos, G. O, Lima, José Geraldo Bomfim, Almeida, Taís Fontoura de, Menezes, Juliana Perrone Bezerra de, Ferreira, C. A. G., Santos, Ricardo Ribeiro dos, Buck, Gregory A., Manque, P. A. M., Ozaqui, L. S., Probst, Christian M., Freitas, Luiz Antonio Rodrigues de, Krieger, Marco Aurélio, Veras, Patrícia Sampaio Tavares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1896
Resumo: Laboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
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spelling Gomes, Ivana NunesPalma, I. C.Campos, G. OLima, José Geraldo BomfimAlmeida, Taís Fontoura deMenezes, Juliana Perrone Bezerra deFerreira, C. A. G.Santos, Ricardo Ribeiro dosBuck, Gregory A.Manque, P. A. M.Ozaqui, L. S.Probst, Christian M.Freitas, Luiz Antonio Rodrigues deKrieger, Marco AurélioVeras, Patrícia Sampaio Tavares2011-04-13T02:15:34Z2011-04-13T02:15:34Z2009GOMES, I. N. et al. The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages. Parasite Immunology, v.31, n.4, p. 188-98, 2009.0141-9838https://www.arca.fiocruz.br/handle/icict/189610.1111/j.1365-3024.2009.01093.xengThe Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Engenharia Tecidual e Imunofarmacologia. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Engenharia Tecidual e Imunofarmacologia. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilDepartment of Microbiology and Immunology and Center for the Study of Biological Complexity, Virginia Commonwealth University, Virginia, USADepartment of Microbiology and Immunology and Center for the Study of Biological Complexity, Virginia Commonwealth University, Virginia, USADepartment of Microbiology and Immunology and Center for the Study of Biological Complexity, Virginia Commonwealth University, Virginia, USAInstituto de Biologia Molecular do Paraná-PR, BrasilLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilInstituto de Biologia Molecular do Paraná-PR, BrasilLaboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilCBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) adorning antigen presenting cell surfaces are known to coordinate the link between innate and adaptive immunity. The macrophage receptor with collagenous structure (MARCO) is a PRR that is preferably expressed by macrophages and is capable of binding Gram-positive and Gram-negative bacteria. No research on the role of MARCO in Leishmania-macrophage interactions has been reported. Here, we demonstrate, for the first time, that MARCO expression by CBA/J macrophages is increased in response to both in vitro and in vivo L. major infections, but not to L. amazonensis infection. In addition, a specific anti-MARCO monoclonal antibody reduced L. major infection of macrophages by 30%-40% in vitro. The draining lymph nodes of anti-MARCO-treated mice displayed a reduced presence of immunolabelled parasite and parasite antigens, as well as a reduced inflammatory response. These results support the hypothesis that MARCO has a role in macrophage infection by L. major in vitro as well as in vivo.Leishmania majorMacrophageMARCOLeishmania majorLeishmanioseLeishmania mexicanaMacrófagos PeritoneaisReceptores ImunológicosCamundongos Endogâmicos CBAAnticorpos AntiprotozoáriosImunidade Inatainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALThe scavenger receptor MARCO.pdfThe scavenger receptor MARCO.pdfapplication/pdf1392501https://www.arca.fiocruz.br/bitstream/icict/1896/1/The%20scavenger%20receptor%20MARCO.pdf640b34171f4feddc4ee0e5a29a9168f3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1896/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTThe scavenger receptor MARCO.pdf.txtThe scavenger receptor MARCO.pdf.txtExtracted texttext/plain50009https://www.arca.fiocruz.br/bitstream/icict/1896/5/The%20scavenger%20receptor%20MARCO.pdf.txt4d07f5e1e61259bb2b2759e1023aab3bMD55THUMBNAILThe scavenger receptor MARCO.pdf.jpgThe scavenger receptor MARCO.pdf.jpgGenerated Thumbnailimage/jpeg2154https://www.arca.fiocruz.br/bitstream/icict/1896/4/The%20scavenger%20receptor%20MARCO.pdf.jpgf92eb086b31d8cf57151d0f3ab1ebb5eMD54icict/18962023-03-15 14:33:23.826oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
spellingShingle The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
Gomes, Ivana Nunes
Leishmania major
Macrophage
MARCO
Leishmania major
Leishmaniose
Leishmania mexicana
Macrófagos Peritoneais
Receptores Imunológicos
Camundongos Endogâmicos CBA
Anticorpos Antiprotozoários
Imunidade Inata
title_short The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_full The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_fullStr The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_full_unstemmed The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_sort The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
author Gomes, Ivana Nunes
author_facet Gomes, Ivana Nunes
Palma, I. C.
Campos, G. O
Lima, José Geraldo Bomfim
Almeida, Taís Fontoura de
Menezes, Juliana Perrone Bezerra de
Ferreira, C. A. G.
Santos, Ricardo Ribeiro dos
Buck, Gregory A.
Manque, P. A. M.
Ozaqui, L. S.
Probst, Christian M.
Freitas, Luiz Antonio Rodrigues de
Krieger, Marco Aurélio
Veras, Patrícia Sampaio Tavares
author_role author
author2 Palma, I. C.
Campos, G. O
Lima, José Geraldo Bomfim
Almeida, Taís Fontoura de
Menezes, Juliana Perrone Bezerra de
Ferreira, C. A. G.
Santos, Ricardo Ribeiro dos
Buck, Gregory A.
Manque, P. A. M.
Ozaqui, L. S.
Probst, Christian M.
Freitas, Luiz Antonio Rodrigues de
Krieger, Marco Aurélio
Veras, Patrícia Sampaio Tavares
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Ivana Nunes
Palma, I. C.
Campos, G. O
Lima, José Geraldo Bomfim
Almeida, Taís Fontoura de
Menezes, Juliana Perrone Bezerra de
Ferreira, C. A. G.
Santos, Ricardo Ribeiro dos
Buck, Gregory A.
Manque, P. A. M.
Ozaqui, L. S.
Probst, Christian M.
Freitas, Luiz Antonio Rodrigues de
Krieger, Marco Aurélio
Veras, Patrícia Sampaio Tavares
dc.subject.en.pt_BR.fl_str_mv Leishmania major
Macrophage
MARCO
topic Leishmania major
Macrophage
MARCO
Leishmania major
Leishmaniose
Leishmania mexicana
Macrófagos Peritoneais
Receptores Imunológicos
Camundongos Endogâmicos CBA
Anticorpos Antiprotozoários
Imunidade Inata
dc.subject.decs.pt_BR.fl_str_mv Leishmania major
Leishmaniose
Leishmania mexicana
Macrófagos Peritoneais
Receptores Imunológicos
Camundongos Endogâmicos CBA
Anticorpos Antiprotozoários
Imunidade Inata
description Laboratório de Patologia e Bio-interveção. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-04-13T02:15:34Z
dc.date.available.fl_str_mv 2011-04-13T02:15:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
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dc.identifier.citation.fl_str_mv GOMES, I. N. et al. The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages. Parasite Immunology, v.31, n.4, p. 188-98, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1896
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-3024.2009.01093.x
identifier_str_mv GOMES, I. N. et al. The Scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages. Parasite Immunology, v.31, n.4, p. 188-98, 2009.
0141-9838
10.1111/j.1365-3024.2009.01093.x
url https://www.arca.fiocruz.br/handle/icict/1896
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