Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5847 |
Resumo: | p. 1-8 |
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Andrade, Bruno BezerrilReis Filho, AntonioSouza Neto, Sebastião MartinsRaffaele-Netto, ImbroiniseCamargo, M. A.Barral, Aldina Maria PradoBarral-Netto, ManoelAndrade, Bruno BezerrilReis Filho, AntonioSouza Neto, Sebastião MartinsRaffaele-Netto, ImbroiniseCamargo, M. A.Barral, Aldina Maria PradoBarral-Netto, Manoel2012-05-11T20:32:26Z2012-05-11T20:32:26Z2010-041935-2727http://www.repositorio.ufba.br/ri/handle/ri/5847v. 4, n. 4p. 1-8Background: Severe outcomes have been described for both Plasmodium falciparum and P. vivax infections. The identification of sensitive and reliable markers of disease severity is fundamental to improving patient care. An intense proinflammatory response with oxidative stress and production of reactive oxygen species is present in malaria. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and antioxidant agents such as superoxide dismutase-1 (SOD-1) are likely candidate biomarkers for disease severity. Here we tested whether plasma levels of SOD-1 could serve as a biomarker of severe vivax malaria. Methodology/Principal Findings: Plasma samples were obtained from residents of the Brazilian Amazon with a high risk for P. vivax transmission. Malaria diagnosis was made by both microscopy and nested PCR. A total of 219 individuals were enrolled: non-infected volunteers (n = 90) and individuals with vivax malaria: asymptomatic (n = 60), mild (n = 50) and severe infection (n = 19). SOD-1 was directly associated with parasitaemia, plasma creatinine and alanine amino-transaminase levels, while TNF-alpha correlated only with the later enzyme. The predictive power of SOD-1 and TNF-alpha levels was compared. SOD-1 protein levels were more effective at predicting vivax malaria severity than TNF-alpha. For discrimination of mild infection, elevated SOD-1 levels showed greater sensitivity than TNF-alpha (76% vs. 30% respectively; p,0.0001), with higher specificity (100% vs. 97%; p,0.0001). In predicting severe vivax malaria, SOD-1 levels exhibited higher sensitivity than TNF-alpha (80% vs. 56%, respectively; p,0.0001; likelihood ratio: 7.45 vs. 3.14; p,0.0001). Neither SOD-1 nor TNF-alpha could discriminate P. vivax infections from those caused by P. falciparum. Conclusion: SOD-1 is a powerful predictor of disease severity in individuals with different clinical presentations of vivax malaria.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-05-11T20:32:26Z No. of bitstreams: 1 (15)journal.pntd.0000650.pdf: 291130 bytes, checksum: 677a455bcfe34360693a66b11ac956cb (MD5)Made available in DSpace on 2012-05-11T20:32:26Z (GMT). No. of bitstreams: 1 (15)journal.pntd.0000650.pdf: 291130 bytes, checksum: 677a455bcfe34360693a66b11ac956cb (MD5) Previous issue date: 2010-0410.1371/journal.pntd.0000650reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAPlasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria SeverityPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL(15)journal.pntd.0000650.pdf(15)journal.pntd.0000650.pdfapplication/pdf291130https://repositorio.ufba.br/bitstream/ri/5847/1/%2815%29journal.pntd.0000650.pdf677a455bcfe34360693a66b11ac956cbMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5847/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(15)journal.pntd.0000650.pdf.txt(15)journal.pntd.0000650.pdf.txtExtracted texttext/plain34274https://repositorio.ufba.br/bitstream/ri/5847/3/%2815%29journal.pntd.0000650.pdf.txte7ab8fdd62f74f50266962b5eb974804MD53ri/58472022-08-08 13:17:28.015oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity |
dc.title.alternative.pt_BR.fl_str_mv |
PLoS Neglected Tropical Diseases |
title |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity |
spellingShingle |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity Andrade, Bruno Bezerril |
title_short |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity |
title_full |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity |
title_fullStr |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity |
title_full_unstemmed |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity |
title_sort |
Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity |
author |
Andrade, Bruno Bezerril |
author_facet |
Andrade, Bruno Bezerril Reis Filho, Antonio Souza Neto, Sebastião Martins Raffaele-Netto, Imbroinise Camargo, M. A. Barral, Aldina Maria Prado Barral-Netto, Manoel |
author_role |
author |
author2 |
Reis Filho, Antonio Souza Neto, Sebastião Martins Raffaele-Netto, Imbroinise Camargo, M. A. Barral, Aldina Maria Prado Barral-Netto, Manoel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Bruno Bezerril Reis Filho, Antonio Souza Neto, Sebastião Martins Raffaele-Netto, Imbroinise Camargo, M. A. Barral, Aldina Maria Prado Barral-Netto, Manoel Andrade, Bruno Bezerril Reis Filho, Antonio Souza Neto, Sebastião Martins Raffaele-Netto, Imbroinise Camargo, M. A. Barral, Aldina Maria Prado Barral-Netto, Manoel |
description |
p. 1-8 |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-04 |
dc.date.accessioned.fl_str_mv |
2012-05-11T20:32:26Z |
dc.date.available.fl_str_mv |
2012-05-11T20:32:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/5847 |
dc.identifier.issn.none.fl_str_mv |
1935-2727 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 4, n. 4 |
identifier_str_mv |
1935-2727 v. 4, n. 4 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/5847 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.source.pt_BR.fl_str_mv |
10.1371/journal.pntd.0000650 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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