Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity

Detalhes bibliográficos
Autor(a) principal: Andrade, Bruno Bezerril
Data de Publicação: 2010
Outros Autores: Reis Filho, Antonio, Souza Neto, Sebastião Martins, Raffaele-Netto, Imbroinise, Camargo, M. A., Barral, Aldina Maria Prado, Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5847
Resumo: p. 1-8
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spelling Andrade, Bruno BezerrilReis Filho, AntonioSouza Neto, Sebastião MartinsRaffaele-Netto, ImbroiniseCamargo, M. A.Barral, Aldina Maria PradoBarral-Netto, ManoelAndrade, Bruno BezerrilReis Filho, AntonioSouza Neto, Sebastião MartinsRaffaele-Netto, ImbroiniseCamargo, M. A.Barral, Aldina Maria PradoBarral-Netto, Manoel2012-05-11T20:32:26Z2012-05-11T20:32:26Z2010-041935-2727http://www.repositorio.ufba.br/ri/handle/ri/5847v. 4, n. 4p. 1-8Background: Severe outcomes have been described for both Plasmodium falciparum and P. vivax infections. The identification of sensitive and reliable markers of disease severity is fundamental to improving patient care. An intense proinflammatory response with oxidative stress and production of reactive oxygen species is present in malaria. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and antioxidant agents such as superoxide dismutase-1 (SOD-1) are likely candidate biomarkers for disease severity. Here we tested whether plasma levels of SOD-1 could serve as a biomarker of severe vivax malaria. Methodology/Principal Findings: Plasma samples were obtained from residents of the Brazilian Amazon with a high risk for P. vivax transmission. Malaria diagnosis was made by both microscopy and nested PCR. A total of 219 individuals were enrolled: non-infected volunteers (n = 90) and individuals with vivax malaria: asymptomatic (n = 60), mild (n = 50) and severe infection (n = 19). SOD-1 was directly associated with parasitaemia, plasma creatinine and alanine amino-transaminase levels, while TNF-alpha correlated only with the later enzyme. The predictive power of SOD-1 and TNF-alpha levels was compared. SOD-1 protein levels were more effective at predicting vivax malaria severity than TNF-alpha. For discrimination of mild infection, elevated SOD-1 levels showed greater sensitivity than TNF-alpha (76% vs. 30% respectively; p,0.0001), with higher specificity (100% vs. 97%; p,0.0001). In predicting severe vivax malaria, SOD-1 levels exhibited higher sensitivity than TNF-alpha (80% vs. 56%, respectively; p,0.0001; likelihood ratio: 7.45 vs. 3.14; p,0.0001). Neither SOD-1 nor TNF-alpha could discriminate P. vivax infections from those caused by P. falciparum. Conclusion: SOD-1 is a powerful predictor of disease severity in individuals with different clinical presentations of vivax malaria.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-05-11T20:32:26Z No. of bitstreams: 1 (15)journal.pntd.0000650.pdf: 291130 bytes, checksum: 677a455bcfe34360693a66b11ac956cb (MD5)Made available in DSpace on 2012-05-11T20:32:26Z (GMT). No. of bitstreams: 1 (15)journal.pntd.0000650.pdf: 291130 bytes, checksum: 677a455bcfe34360693a66b11ac956cb (MD5) Previous issue date: 2010-0410.1371/journal.pntd.0000650reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAPlasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria SeverityPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL(15)journal.pntd.0000650.pdf(15)journal.pntd.0000650.pdfapplication/pdf291130https://repositorio.ufba.br/bitstream/ri/5847/1/%2815%29journal.pntd.0000650.pdf677a455bcfe34360693a66b11ac956cbMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5847/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(15)journal.pntd.0000650.pdf.txt(15)journal.pntd.0000650.pdf.txtExtracted texttext/plain34274https://repositorio.ufba.br/bitstream/ri/5847/3/%2815%29journal.pntd.0000650.pdf.txte7ab8fdd62f74f50266962b5eb974804MD53ri/58472022-08-08 13:17:28.015oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
dc.title.alternative.pt_BR.fl_str_mv PLoS Neglected Tropical Diseases
title Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
spellingShingle Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
Andrade, Bruno Bezerril
title_short Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
title_full Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
title_fullStr Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
title_full_unstemmed Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
title_sort Plasma Superoxide Dismutase-1 as a Surrogate Marker of Vivax Malaria Severity
author Andrade, Bruno Bezerril
author_facet Andrade, Bruno Bezerril
Reis Filho, Antonio
Souza Neto, Sebastião Martins
Raffaele-Netto, Imbroinise
Camargo, M. A.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author_role author
author2 Reis Filho, Antonio
Souza Neto, Sebastião Martins
Raffaele-Netto, Imbroinise
Camargo, M. A.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Bruno Bezerril
Reis Filho, Antonio
Souza Neto, Sebastião Martins
Raffaele-Netto, Imbroinise
Camargo, M. A.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Andrade, Bruno Bezerril
Reis Filho, Antonio
Souza Neto, Sebastião Martins
Raffaele-Netto, Imbroinise
Camargo, M. A.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
description p. 1-8
publishDate 2010
dc.date.issued.fl_str_mv 2010-04
dc.date.accessioned.fl_str_mv 2012-05-11T20:32:26Z
dc.date.available.fl_str_mv 2012-05-11T20:32:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5847
dc.identifier.issn.none.fl_str_mv 1935-2727
dc.identifier.number.pt_BR.fl_str_mv v. 4, n. 4
identifier_str_mv 1935-2727
v. 4, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/5847
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv 10.1371/journal.pntd.0000650
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