Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13792 |
Resumo: | Texto completo: acesso restrito. p. 1196-1204 |
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Andrade, Bruno BezerrilSantos, Théo AraújoLuz, Nívea FariasCunha, Antônio Ricardo KhouriBozza, Marcelo TorresCamargo, Luís Marcelo AranhaBarral, Aldina Maria PradoBorges, Valéria de MatosBarral-Netto, ManoelAndrade, Bruno BezerrilSantos, Théo AraújoLuz, Nívea FariasCunha, Antônio Ricardo KhouriBozza, Marcelo TorresCamargo, Luís Marcelo AranhaBarral, Aldina Maria PradoBorges, Valéria de MatosBarral-Netto, Manoel2013-11-19T20:40:11Z20100022-1767http://repositorio.ufba.br/ri/handle/ri/13792v. 185, n. 2Texto completo: acesso restrito. p. 1196-1204In many hemolytic disorders, such as malaria, the release of free heme has been involved in the triggering of oxidative stress and tissue damage. Patients presenting with severe forms of malaria commonly have impaired regulatory responses. Although intriguing, there is scarce data about the involvement of heme on the regulation of immune responses. In this study, we investigated the relation of free heme and the suppression of anti-inflammatory mediators such as PGE2 and TGF-β in human vivax malaria. Patients with severe disease presented higher hemolysis and higher plasma concentrations of Cu/Zn superoxide dismutase (SOD-1) and lower concentrations of PGE2 and TGF-β than those with mild disease. In addition, there was a positive correlation between SOD-1 concentrations and plasma levels of TNF-α. During antimalaria treatment, the concentrations of plasma SOD-1 reduced whereas PGE2 and TGF-β increased in the individuals severely ill. Using an in vitro model with human mononuclear cells, we demonstrated that the heme effect on the impairment of the production of PGE2 and TGF-β partially involves heme binding to CD14 and depends on the production of SOD-1. Aside from furthering the current knowledge about the pathogenesis of vivax malaria, the present results may represent a general mechanism for hemolytic diseases and could be useful for future studies of therapeutic approaches.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-23T14:40:35Z No. of bitstreams: 1 J Immunol-2010-Andrade-1196-204.pdf: 1348326 bytes, checksum: 42e0021612e2b54c4110929e5b0f7e6c (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T20:40:11Z (GMT) No. of bitstreams: 1 J Immunol-2010-Andrade-1196-204.pdf: 1348326 bytes, checksum: 42e0021612e2b54c4110929e5b0f7e6c (MD5)Made available in DSpace on 2013-11-19T20:40:11Z (GMT). No. of bitstreams: 1 J Immunol-2010-Andrade-1196-204.pdf: 1348326 bytes, checksum: 42e0021612e2b54c4110929e5b0f7e6c (MD5) Previous issue date: 2010http://dx.doi.org/10.4049/jimmunol.0904179reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHeme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malariaJournal of Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALJ Immunol-2010-Andrade-1196-204.pdfJ Immunol-2010-Andrade-1196-204.pdfapplication/pdf1348326https://repositorio.ufba.br/bitstream/ri/13792/1/J%20Immunol-2010-Andrade-1196-204.pdf42e0021612e2b54c4110929e5b0f7e6cMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13792/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTJ Immunol-2010-Andrade-1196-204.pdf.txtJ Immunol-2010-Andrade-1196-204.pdf.txtExtracted texttext/plain56293https://repositorio.ufba.br/bitstream/ri/13792/3/J%20Immunol-2010-Andrade-1196-204.pdf.txt827d9e372d19b06ff2b369ddf1032af0MD53ri/137922022-08-08 13:17:28.051oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Immunology |
| title |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria |
| spellingShingle |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria Andrade, Bruno Bezerril |
| title_short |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria |
| title_full |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria |
| title_fullStr |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria |
| title_full_unstemmed |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria |
| title_sort |
Heme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria |
| author |
Andrade, Bruno Bezerril |
| author_facet |
Andrade, Bruno Bezerril Santos, Théo Araújo Luz, Nívea Farias Cunha, Antônio Ricardo Khouri Bozza, Marcelo Torres Camargo, Luís Marcelo Aranha Barral, Aldina Maria Prado Borges, Valéria de Matos Barral-Netto, Manoel |
| author_role |
author |
| author2 |
Santos, Théo Araújo Luz, Nívea Farias Cunha, Antônio Ricardo Khouri Bozza, Marcelo Torres Camargo, Luís Marcelo Aranha Barral, Aldina Maria Prado Borges, Valéria de Matos Barral-Netto, Manoel |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Bruno Bezerril Santos, Théo Araújo Luz, Nívea Farias Cunha, Antônio Ricardo Khouri Bozza, Marcelo Torres Camargo, Luís Marcelo Aranha Barral, Aldina Maria Prado Borges, Valéria de Matos Barral-Netto, Manoel Andrade, Bruno Bezerril Santos, Théo Araújo Luz, Nívea Farias Cunha, Antônio Ricardo Khouri Bozza, Marcelo Torres Camargo, Luís Marcelo Aranha Barral, Aldina Maria Prado Borges, Valéria de Matos Barral-Netto, Manoel |
| description |
Texto completo: acesso restrito. p. 1196-1204 |
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2010 |
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2010 |
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2013-11-19T20:40:11Z |
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0022-1767 |
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v. 185, n. 2 |
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0022-1767 v. 185, n. 2 |
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