Regeneration of critical bone defects with anionic collagen matrix as scaffolds

Detalhes bibliográficos
Autor(a) principal: Miguel, Fúlvio Borges
Data de Publicação: 2013
Outros Autores: Barbosa Júnior, Aryon de Almeida, Paula, Fabiana Lopes de, Barreto, Isabela Cerqueira, Goissis, Gilberto, Rosa, Fabiana Paim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14894
Resumo: Texto completo: acesso restrito. p. 2567-2575
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spelling Miguel, Fúlvio BorgesBarbosa Júnior, Aryon de AlmeidaPaula, Fabiana Lopes deBarreto, Isabela CerqueiraGoissis, GilbertoRosa, Fabiana PaimMiguel, Fúlvio BorgesBarbosa Júnior, Aryon de AlmeidaPaula, Fabiana Lopes deBarreto, Isabela CerqueiraGoissis, GilbertoRosa, Fabiana Paim2014-05-01T13:08:08Z20130957-4530http://repositorio.ufba.br/ri/handle/ri/14894v. 24, n. 11Texto completo: acesso restrito. p. 2567-2575The aim of this study was to make a histomorphometric evaluation of the osteogenic potential of anionic collagen matrix as scaffolds; either crosslinked in glutaraldehyde or not cross-linked and, implanted in critical bone defects in rat calvaria. Seventy-two rats were randomly distributed in three groups: anionic collagen scaffolds treated for 24 h of selective hydrolysis (ACSH); anionic collagen scaffolds treated for 24 h of selective hydrolysis and 5 min of crosslinking in glutaraldehyde 0.05 % (ACSHGA); empty bone defect (Control), evaluated at the biological points of 15, 45, 90 and 120 days. The results showed that the biomaterials implanted were biocompatible and showed a high osteogenic potential. These biomaterials presented a speed of biodegradation compatible with bone neoformation, which was shown to be associated with angiogenesis inside the scaffolds at all biological points. The percentage of mineralization of ACSH (87 %) differed statistically from that found in ACSHGA (66 %). It was concluded that the regeneration of critical bone defect was more evident in anionic collagen without crosslinking (ACSH).Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-15T11:52:11Z No. of bitstreams: 1 art%3A10.1007%2Fs10856-013-4980-8.pdf: 646690 bytes, checksum: 8ce2b1adb50829fc2682b9c4b430159e (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-05-01T13:08:08Z (GMT) No. of bitstreams: 1 art%3A10.1007%2Fs10856-013-4980-8.pdf: 646690 bytes, checksum: 8ce2b1adb50829fc2682b9c4b430159e (MD5)Made available in DSpace on 2014-05-01T13:08:08Z (GMT). No. of bitstreams: 1 art%3A10.1007%2Fs10856-013-4980-8.pdf: 646690 bytes, checksum: 8ce2b1adb50829fc2682b9c4b430159e (MD5) Previous issue date: 2013http://dx.doi.org/10.1007/s10856-013-4980-8reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBARegeneration of critical bone defects with anionic collagen matrix as scaffoldsJournal of Materials Science: Materials in Medicineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14894/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALart%3A10.1007%2Fs10856-013-4980-8.pdfart%3A10.1007%2Fs10856-013-4980-8.pdfapplication/pdf646690https://repositorio.ufba.br/bitstream/ri/14894/1/art%253A10.1007%252Fs10856-013-4980-8.pdf8ce2b1adb50829fc2682b9c4b430159eMD51TEXTart%3A10.1007%2Fs10856-013-4980-8.pdf.txtart%3A10.1007%2Fs10856-013-4980-8.pdf.txtExtracted texttext/plain34206https://repositorio.ufba.br/bitstream/ri/14894/3/art%253A10.1007%252Fs10856-013-4980-8.pdf.txtbdbd845ecfd18dff157b8a760283bd3dMD53ri/148942022-07-05 14:03:11.427oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:11Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Regeneration of critical bone defects with anionic collagen matrix as scaffolds
dc.title.alternative.pt_BR.fl_str_mv Journal of Materials Science: Materials in Medicine
title Regeneration of critical bone defects with anionic collagen matrix as scaffolds
spellingShingle Regeneration of critical bone defects with anionic collagen matrix as scaffolds
Miguel, Fúlvio Borges
title_short Regeneration of critical bone defects with anionic collagen matrix as scaffolds
title_full Regeneration of critical bone defects with anionic collagen matrix as scaffolds
title_fullStr Regeneration of critical bone defects with anionic collagen matrix as scaffolds
title_full_unstemmed Regeneration of critical bone defects with anionic collagen matrix as scaffolds
title_sort Regeneration of critical bone defects with anionic collagen matrix as scaffolds
author Miguel, Fúlvio Borges
author_facet Miguel, Fúlvio Borges
Barbosa Júnior, Aryon de Almeida
Paula, Fabiana Lopes de
Barreto, Isabela Cerqueira
Goissis, Gilberto
Rosa, Fabiana Paim
author_role author
author2 Barbosa Júnior, Aryon de Almeida
Paula, Fabiana Lopes de
Barreto, Isabela Cerqueira
Goissis, Gilberto
Rosa, Fabiana Paim
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Miguel, Fúlvio Borges
Barbosa Júnior, Aryon de Almeida
Paula, Fabiana Lopes de
Barreto, Isabela Cerqueira
Goissis, Gilberto
Rosa, Fabiana Paim
Miguel, Fúlvio Borges
Barbosa Júnior, Aryon de Almeida
Paula, Fabiana Lopes de
Barreto, Isabela Cerqueira
Goissis, Gilberto
Rosa, Fabiana Paim
description Texto completo: acesso restrito. p. 2567-2575
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-05-01T13:08:08Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14894
dc.identifier.issn.none.fl_str_mv 0957-4530
dc.identifier.number.pt_BR.fl_str_mv v. 24, n. 11
identifier_str_mv 0957-4530
v. 24, n. 11
url http://repositorio.ufba.br/ri/handle/ri/14894
dc.language.iso.fl_str_mv eng
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