Regeneration of critical bone defects with anionic collagen matrix as scaffolds.

Detalhes bibliográficos
Autor(a) principal: Miguel, Fúlvio Borges
Data de Publicação: 2013
Outros Autores: Barbosa Junior, Aryon de Almeida, Paula, Fabiana Lopes de, Barreto, Isabela Cerqueira, Goissis, Gilberto, Rosa, Fabiana Paim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7796
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
id CRUZ_fa44a5195c842f5525f94414c25092d4
oai_identifier_str oai:www.arca.fiocruz.br:icict/7796
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Miguel, Fúlvio BorgesBarbosa Junior, Aryon de AlmeidaPaula, Fabiana Lopes deBarreto, Isabela CerqueiraGoissis, GilbertoRosa, Fabiana Paim2014-06-04T19:41:27Z2014-06-04T19:41:27Z2013MIGUEL, F. B. et al. Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Journal of Materials Science: Materials in Medicine, v. 24, n. 11, p. 2567-275, 2013.1573-4838https://www.arca.fiocruz.br/handle/icict/779610.1007/s10856-013-4980-8engSpringer VerlagRegeneration of critical bone defects with anionic collagen matrix as scaffolds.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHealth Sciences Center of Federal University of the Recôncavo of Bahia. Santo Antônio de Jesus, BA, BrasilHealth Sciences Institute of Federal University of Bahia. Salvador, BA, BrasilBiotech Biomédica. São Carlos, SP, BrasilHealth Sciences Institute of Federal University of Bahia. Salvador, BA, BrasilThe aim of this study was to make a histomorphometric evaluation of the osteogenic potential of anionic collagen matrix as scaffolds; either crosslinked in glutaraldehyde or not cross-linked and, implanted in critical bone defects in rat calvaria. Seventy-two rats were randomly distributed in three groups: anionic collagen scaffolds treated for 24 h of selective hydrolysis (ACSH); anionic collagen scaffolds treated for 24 h of selective hydrolysis and 5 min of crosslinking in glutaraldehyde 0.05% (ACSHGA); empty bone defect (Control), evaluated at the biological points of 15, 45, 90 and 120 days. The results showed that the biomaterials implanted were biocompatible and showed a high osteogenic potential. These biomaterials presented a speed of biodegradation compatible with bone neoformation, which was shown to be associated with angiogenesis inside the scaffolds at all biological points. The percentage of mineralization of ACSH (87%) differed statistically from that found in ACSHGA (66%). It was concluded that the regeneration of critical bone defect was more evident in anionic collagen without crosslinking (ACSH).ColágenoOssosAnimaisRatosImplanteBiomateriaisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMiguel FB Regeneration of....pdfMiguel FB Regeneration of....pdfapplication/pdf646690https://www.arca.fiocruz.br/bitstream/icict/7796/1/Miguel%20FB%20Regeneration%20of....pdf8ce2b1adb50829fc2682b9c4b430159eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7796/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMiguel FB Regeneration of....pdf.txtMiguel FB Regeneration of....pdf.txtExtracted texttext/plain34206https://www.arca.fiocruz.br/bitstream/icict/7796/5/Miguel%20FB%20Regeneration%20of....pdf.txtbdbd845ecfd18dff157b8a760283bd3dMD55THUMBNAILMiguel FB Regeneration of....pdf.jpgMiguel FB Regeneration of....pdf.jpgGenerated Thumbnailimage/jpeg2078https://www.arca.fiocruz.br/bitstream/icict/7796/4/Miguel%20FB%20Regeneration%20of....pdf.jpg7e10cad5876c357d0051ef238a925af2MD54icict/77962023-03-15 14:33:19.483oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
title Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
spellingShingle Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
Miguel, Fúlvio Borges
Colágeno
Ossos
Animais
Ratos
Implante
Biomateriais
title_short Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
title_full Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
title_fullStr Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
title_full_unstemmed Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
title_sort Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
author Miguel, Fúlvio Borges
author_facet Miguel, Fúlvio Borges
Barbosa Junior, Aryon de Almeida
Paula, Fabiana Lopes de
Barreto, Isabela Cerqueira
Goissis, Gilberto
Rosa, Fabiana Paim
author_role author
author2 Barbosa Junior, Aryon de Almeida
Paula, Fabiana Lopes de
Barreto, Isabela Cerqueira
Goissis, Gilberto
Rosa, Fabiana Paim
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Miguel, Fúlvio Borges
Barbosa Junior, Aryon de Almeida
Paula, Fabiana Lopes de
Barreto, Isabela Cerqueira
Goissis, Gilberto
Rosa, Fabiana Paim
dc.subject.decs.pt_BR.fl_str_mv Colágeno
Ossos
Animais
Ratos
Implante
Biomateriais
topic Colágeno
Ossos
Animais
Ratos
Implante
Biomateriais
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-06-04T19:41:27Z
dc.date.available.fl_str_mv 2014-06-04T19:41:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIGUEL, F. B. et al. Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Journal of Materials Science: Materials in Medicine, v. 24, n. 11, p. 2567-275, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7796
dc.identifier.issn.none.fl_str_mv 1573-4838
dc.identifier.doi.none.fl_str_mv 10.1007/s10856-013-4980-8
identifier_str_mv MIGUEL, F. B. et al. Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Journal of Materials Science: Materials in Medicine, v. 24, n. 11, p. 2567-275, 2013.
1573-4838
10.1007/s10856-013-4980-8
url https://www.arca.fiocruz.br/handle/icict/7796
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7796/1/Miguel%20FB%20Regeneration%20of....pdf
https://www.arca.fiocruz.br/bitstream/icict/7796/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/7796/5/Miguel%20FB%20Regeneration%20of....pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/7796/4/Miguel%20FB%20Regeneration%20of....pdf.jpg
bitstream.checksum.fl_str_mv 8ce2b1adb50829fc2682b9c4b430159e
7d48279ffeed55da8dfe2f8e81f3b81f
bdbd845ecfd18dff157b8a760283bd3d
7e10cad5876c357d0051ef238a925af2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324615914717184

Registros relacionados