Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16413 |
Resumo: | Texto completo: acesso restrito. p. 4460-4467 |
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Luz, Nívea FariasAndrade, Bruno BezerrilFeijó, Daniel F.Santos, Théo AraújoCarvalho, Graziele Q.Andrade, DanielaAbánades, Daniel RuizMelo, Enaldo Vieira deSilva, Angela M.Brodskyn, Claudia IdaBarral-Netto, ManoelBarral, Aldina Maria PradoSoares, Rodrigo P.Almeida, Roque Pacheco deBozza, Marcelo TorresBorges, Valéria de MatosLuz, Nívea FariasAndrade, Bruno BezerrilFeijó, Daniel F.Santos, Théo AraújoCarvalho, Graziele Q.Andrade, DanielaAbánades, Daniel RuizMelo, Enaldo Vieira deSilva, Angela M.Brodskyn, Claudia IdaBarral-Netto, ManoelBarral, Aldina Maria PradoSoares, Rodrigo P.Almeida, Roque Pacheco deBozza, Marcelo TorresBorges, Valéria de Matos2014-10-14T12:13:10Z20120022-1767http://repositorio.ufba.br/ri/handle/ri/16413v. 188, n. 9Texto completo: acesso restrito. p. 4460-4467Visceral leishmaniasis (VL) remains a major public health problem worldwide. This disease is highly associated with chronic inflammation and a lack of the cellular immune responses against Leishmania. It is important to identify major factors driving the successful establishment of the Leishmania infection to develop better tools for the disease control. Heme oxygenase-1 (HO-1) is a key enzyme triggered by cellular stress, and its role in VL has not been investigated. In this study, we evaluated the role of HO-1 in the infection by Leishmania infantum chagasi, the causative agent of VL cases in Brazil. We found that L. chagasi infection or lipophosphoglycan isolated from promastigotes triggered HO-1 production by murine macrophages. Interestingly, cobalt protoporphyrin IX, an HO-1 inductor, increased the parasite burden in both mouse and human-derived macrophages. Upon L. chagasi infection, macrophages from Hmox1 knockout mice presented significantly lower parasite loads when compared with those from wild-type mice. Furthermore, upregulation of HO-1 by cobalt protoporphyrin IX diminished the production of TNF-α and reactive oxygen species by infected murine macrophages and increased Cu/Zn superoxide dismutase expression in human monocytes. Finally, patients with VL presented higher systemic concentrations of HO-1 than healthy individuals, and this increase of HO-1 was reduced after antileishmanial treatment, suggesting that HO-1 is associated with disease susceptibility. Our data argue that HO-1 has a critical role in the L. chagasi infection and is strongly associated with the inflammatory imbalance during VL. Manipulation of HO-1 pathways during VL could serve as an adjunctive therapeutic approach.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-11T13:43:08Z No. of bitstreams: 1 Nívea F. Luz.pdf: 1584833 bytes, checksum: aeb0961f7c6201b1a38868d69549901f (MD5)Rejected by Delba Rosa (delba@ufba.br), reason: Por gentileza, Cite todos os autores; O endereço eletrônico não confere. Grata on 2014-10-09T16:03:14Z (GMT)Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-10-14T11:18:15Z No. of bitstreams: 1 Nívea F. Luz.pdf: 1584833 bytes, checksum: aeb0961f7c6201b1a38868d69549901f (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-10-14T12:13:10Z (GMT) No. of bitstreams: 1 Nívea F. Luz.pdf: 1584833 bytes, checksum: aeb0961f7c6201b1a38868d69549901f (MD5)Made available in DSpace on 2014-10-14T12:13:10Z (GMT). No. of bitstreams: 1 Nívea F. Luz.pdf: 1584833 bytes, checksum: aeb0961f7c6201b1a38868d69549901f (MD5) Previous issue date: 2012http://dx.doi.org/10.4049/jimmunol.1103072reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHeme Oxygenase-1 Promotes the Persistence of Leishmania chagasi InfectionJournal of Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16413/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALNívea F. Luz.pdfNívea F. Luz.pdfapplication/pdf1584833https://repositorio.ufba.br/bitstream/ri/16413/1/N%c3%advea%20F.%20Luz.pdfaeb0961f7c6201b1a38868d69549901fMD51TEXTNívea F. Luz.pdf.txtNívea F. Luz.pdf.txtExtracted texttext/plain62186https://repositorio.ufba.br/bitstream/ri/16413/3/N%c3%advea%20F.%20Luz.pdf.txt086604073790849e6e82490ca556b0a4MD53ri/164132022-08-08 13:18:35.772oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:35Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Immunology |
| title |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection |
| spellingShingle |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection Luz, Nívea Farias |
| title_short |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection |
| title_full |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection |
| title_fullStr |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection |
| title_full_unstemmed |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection |
| title_sort |
Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection |
| author |
Luz, Nívea Farias |
| author_facet |
Luz, Nívea Farias Andrade, Bruno Bezerril Feijó, Daniel F. Santos, Théo Araújo Carvalho, Graziele Q. Andrade, Daniela Abánades, Daniel Ruiz Melo, Enaldo Vieira de Silva, Angela M. Brodskyn, Claudia Ida Barral-Netto, Manoel Barral, Aldina Maria Prado Soares, Rodrigo P. Almeida, Roque Pacheco de Bozza, Marcelo Torres Borges, Valéria de Matos |
| author_role |
author |
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Andrade, Bruno Bezerril Feijó, Daniel F. Santos, Théo Araújo Carvalho, Graziele Q. Andrade, Daniela Abánades, Daniel Ruiz Melo, Enaldo Vieira de Silva, Angela M. Brodskyn, Claudia Ida Barral-Netto, Manoel Barral, Aldina Maria Prado Soares, Rodrigo P. Almeida, Roque Pacheco de Bozza, Marcelo Torres Borges, Valéria de Matos |
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author author author author author author author author author author author author author author author |
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Luz, Nívea Farias Andrade, Bruno Bezerril Feijó, Daniel F. Santos, Théo Araújo Carvalho, Graziele Q. Andrade, Daniela Abánades, Daniel Ruiz Melo, Enaldo Vieira de Silva, Angela M. Brodskyn, Claudia Ida Barral-Netto, Manoel Barral, Aldina Maria Prado Soares, Rodrigo P. Almeida, Roque Pacheco de Bozza, Marcelo Torres Borges, Valéria de Matos Luz, Nívea Farias Andrade, Bruno Bezerril Feijó, Daniel F. Santos, Théo Araújo Carvalho, Graziele Q. Andrade, Daniela Abánades, Daniel Ruiz Melo, Enaldo Vieira de Silva, Angela M. Brodskyn, Claudia Ida Barral-Netto, Manoel Barral, Aldina Maria Prado Soares, Rodrigo P. Almeida, Roque Pacheco de Bozza, Marcelo Torres Borges, Valéria de Matos |
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Texto completo: acesso restrito. p. 4460-4467 |
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2012 |
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2012 |
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2014-10-14T12:13:10Z |
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v. 188, n. 9 |
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