Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases

Detalhes bibliográficos
Autor(a) principal: Araujo, Maria Ilma Andrade Santos
Data de Publicação: 2004
Outros Autores: Hoppe, Bradford S., Medeiros Junior, Manoel, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/4816
Resumo: p. 27-32
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spelling Araujo, Maria Ilma Andrade SantosHoppe, Bradford S.Medeiros Junior, ManoelCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade SantosHoppe, Bradford S.Medeiros Junior, ManoelCarvalho Filho, Edgar Marcelino de2011-12-12T14:18:58Z2011-12-12T14:18:58Z20041678-8060http://www.repositorio.ufba.br/ri/handle/ri/4816v. 99 (Suppl. I)p. 27-32Chronic Schistosoma mansoni infection leads to a type 2-immune response with increased production of interleukin (IL-10). Evidence indicates chronic exposure to S. mansoni down regulates the type 1 immune response and prevents the onset of Th1-mediated diseases such as multiple sclerosis, diabetes mellitus and Cronh’s disease. Furthermore, our own studies have revealed that chronic exposure to S. mansoni also down regulates atopic disease, Th2-mediated diseases. Our studies show an inverse association between the skin prick test reactivity and infection with S. mansoni and show the severity of asthma is reduced in subjects living in an endemic area of S. mansoni. Moreover, we hypothesize the mechanisms involved in the modulation of inflammatory response in atopic individuals, is likely dependent on IL-10 production, an anti-inflammatory cytokine elevated during helminth infections. Patients with asthma and helminth infections produced less IL-5 than patients with asthma without helminth infections, and this down regulation could, in part, be mediated by IL-10. In conclusion, helminthic infections, through induction of regulatory mechanisms, such as IL-10 production, are able to modulate the inflammatory immune response involved in the pathology of auto-immune and allergic disease.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-12-12T14:18:58Z No. of bitstreams: 1 v99s1a05.pdf: 47677 bytes, checksum: 45a0bac406928fc84816248158672c2b (MD5)Made available in DSpace on 2011-12-12T14:18:58Z (GMT). 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dc.title.pt_BR.fl_str_mv Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
spellingShingle Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
Araujo, Maria Ilma Andrade Santos
Schistosoma mansoni
alergic disease
asthma
auto-immune diseases
title_short Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
title_full Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
title_fullStr Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
title_full_unstemmed Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
title_sort Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases
author Araujo, Maria Ilma Andrade Santos
author_facet Araujo, Maria Ilma Andrade Santos
Hoppe, Bradford S.
Medeiros Junior, Manoel
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Hoppe, Bradford S.
Medeiros Junior, Manoel
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
dc.contributor.author.fl_str_mv Araujo, Maria Ilma Andrade Santos
Hoppe, Bradford S.
Medeiros Junior, Manoel
Carvalho Filho, Edgar Marcelino de
Araujo, Maria Ilma Andrade Santos
Hoppe, Bradford S.
Medeiros Junior, Manoel
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Schistosoma mansoni
alergic disease
asthma
auto-immune diseases
topic Schistosoma mansoni
alergic disease
asthma
auto-immune diseases
description p. 27-32
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2011-12-12T14:18:58Z
dc.date.available.fl_str_mv 2011-12-12T14:18:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/4816
dc.identifier.issn.none.fl_str_mv 1678-8060
dc.identifier.number.pt_BR.fl_str_mv v. 99 (Suppl. I)
identifier_str_mv 1678-8060
v. 99 (Suppl. I)
url http://www.repositorio.ufba.br/ri/handle/ri/4816
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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