Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1981 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13396 |
Resumo: | Texto completo. Acesso restrito. p. 1–11 |
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1932 |
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Toopozada, H. K.Koetsawang, S.Aimakhu, V. E.Khan, T.Pretnar, A.Chatterjee, T. K.Molitor-Peffer, M. P.Apelo, R.Lichtenberg, R.Crosignani, P. G.Souza, J. Caetano deGomez-Rogers, C.Haspels, A. A.Gray, R. H.Diethelm, P.Benaginao, G.Annus, J.Toopozada, H. K.Koetsawang, S.Aimakhu, V. E.Khan, T.Pretnar, A.Chatterjee, T. K.Molitor-Peffer, M. P.Apelo, R.Lichtenberg, R.Crosignani, P. G.Souza, J. Caetano deGomez-Rogers, C.Haspels, A. A.Gray, R. H.Diethelm, P.Benaginao, G.Annus, J.2013-10-31T17:37:46Z19810010-7824http://repositorio.ufba.br/ri/handle/ri/13396v. 25, n. 1Texto completo. Acesso restrito. p. 1–11A multicentre phase III clinical trial has been undertaken to compare norethisterone enantate (NET-EN) given by two different treatment regimens and depot-medroxyprogesterone acetate (DMPA). After 18 months of observation, preliminary findings are reported for 1,589 women who received DMPA 150mg every 90 days; 790 women who received NET-EN 200mg every 60 days; and 796 women who received NET-EN, 200mg every 60 days for 6 months, then 200mg every 84 days. The overall discontinuation rates per 100 women were similar for all three treatment groups over the 18 months observation (61.8–63.5 per 100 women). The discontinuation rates for bleeding problems and for personal reasons were also similar for all three treatment groups. However, terminations due to amenorrhoea were significantly higher among DMPA users (12.1 and 17.4 per 100 women at 12 and 18 months) as compared with both NET-EN groups (6.8–8.2 per 100 women at 12 months and 10.4–10.9 per 100 women at 18 months). The only significant difference in pregnancy rates observed between the three groups was a higher rate at 18 months among NET-EN (84 days) users (1.6 per 100 women), as compared with DMPA users (0.2 per 100 women). There was no overall significant difference between the two NET-EN groups, although between the 6 and 18 month's follow-up when the two NET-EN regimens diverged, the NET-EN (84 days) users' pregnancy rate rose significantly, wherease in the NET-EN (60 days) group the pregnancy rate did not change. There was a significantly higher weight gain in those subjects using NET-EN at 60-day intervals compared with those using it at 84-day intervals.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-25T19:40:27Z No. of bitstreams: 1 666666666666666666666.pdf: 547892 bytes, checksum: 8bd639491de95476a0b72ce56d5af5ff (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:37:46Z (GMT) No. of bitstreams: 1 666666666666666666666.pdf: 547892 bytes, checksum: 8bd639491de95476a0b72ce56d5af5ff (MD5)Made available in DSpace on 2013-10-31T17:37:46Z (GMT). No. of bitstreams: 1 666666666666666666666.pdf: 547892 bytes, checksum: 8bd639491de95476a0b72ce56d5af5ff (MD5) Previous issue date: 1981SalvadorContraceptionhttp://www-sciencedirect-com.ez10.periodicos.capes.gov.br/science/article/pii/0010782482900142reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMultinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. 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| dc.title.pt_BR.fl_str_mv |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report |
| dc.title.alternative.pt_BR.fl_str_mv |
Contraception |
| title |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report |
| spellingShingle |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report Toopozada, H. K. |
| title_short |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report |
| title_full |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report |
| title_fullStr |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report |
| title_full_unstemmed |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report |
| title_sort |
Multinational comparative clinical trial of long-acting injectable contraceptives: norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. A preliminary report |
| author |
Toopozada, H. K. |
| author_facet |
Toopozada, H. K. Koetsawang, S. Aimakhu, V. E. Khan, T. Pretnar, A. Chatterjee, T. K. Molitor-Peffer, M. P. Apelo, R. Lichtenberg, R. Crosignani, P. G. Souza, J. Caetano de Gomez-Rogers, C. Haspels, A. A. Gray, R. H. Diethelm, P. Benaginao, G. Annus, J. |
| author_role |
author |
| author2 |
Koetsawang, S. Aimakhu, V. E. Khan, T. Pretnar, A. Chatterjee, T. K. Molitor-Peffer, M. P. Apelo, R. Lichtenberg, R. Crosignani, P. G. Souza, J. Caetano de Gomez-Rogers, C. Haspels, A. A. Gray, R. H. Diethelm, P. Benaginao, G. Annus, J. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Toopozada, H. K. Koetsawang, S. Aimakhu, V. E. Khan, T. Pretnar, A. Chatterjee, T. K. Molitor-Peffer, M. P. Apelo, R. Lichtenberg, R. Crosignani, P. G. Souza, J. Caetano de Gomez-Rogers, C. Haspels, A. A. Gray, R. H. Diethelm, P. Benaginao, G. Annus, J. Toopozada, H. K. Koetsawang, S. Aimakhu, V. E. Khan, T. Pretnar, A. Chatterjee, T. K. Molitor-Peffer, M. P. Apelo, R. Lichtenberg, R. Crosignani, P. G. Souza, J. Caetano de Gomez-Rogers, C. Haspels, A. A. Gray, R. H. Diethelm, P. Benaginao, G. Annus, J. |
| description |
Texto completo. Acesso restrito. p. 1–11 |
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1981 |
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1981 |
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2013-10-31T17:37:46Z |
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info:eu-repo/semantics/publishedVersion |
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http://repositorio.ufba.br/ri/handle/ri/13396 |
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0010-7824 |
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v. 25, n. 1 |
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0010-7824 v. 25, n. 1 |
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http://repositorio.ufba.br/ri/handle/ri/13396 |
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Contraception |
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Contraception |
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http://www-sciencedirect-com.ez10.periodicos.capes.gov.br/science/article/pii/0010782482900142 |
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