Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction

Detalhes bibliográficos
Autor(a) principal: Souza, J. Caetano de
Data de Publicação: 1983
Outros Autores: Toppozada, H. K., Koetsawang, S., Aimakhu, V. E., Khan, T., Pretnar-Darovec, A., Chatterjee, T. K., Molitor-Peffer, M. P., Apelo, R., Lichtenberg, R., Crosignani, P. G., Huidubro, M. Garcia, Haspels, A. A., Annus, J., Benaginao, G., Diethelm, P., Gray, R., Hall, P. E., Holck, S. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13332
Resumo: Texto completo. Acesso restrito. p. 1–20
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spelling Souza, J. Caetano deToppozada, H. K.Koetsawang, S.Aimakhu, V. E.Khan, T.Pretnar-Darovec, A.Chatterjee, T. K.Molitor-Peffer, M. P.Apelo, R.Lichtenberg, R.Crosignani, P. G.Huidubro, M. GarciaHaspels, A. A.Annus, J.Benaginao, G.Diethelm, P.Gray, R.Hall, P. E.Holck, S. E.2013-10-30T17:46:58Z19830010-7824http://repositorio.ufba.br/ri/handle/ri/13332v. 28, n. 1Texto completo. Acesso restrito. p. 1–20Final results are presented from a two-year WHO multinational comparative trial of three regimens: depot-medroxyprogesterone acetate (DMPA) given at 90-day intervals, norethisterone enantate (NET-EN) given at 60-day intervals for the entire study period (NET-EN (60-day)), and NET-EN given at 60-day intervals for six months and thereafter at 84-day intervals (NET-EN (84-day)). 1587 DMPA subjects were observed for 20,550 woman-months, 789 NET-EN (60-day) subjects were observed for 10,361 woman-months, and 796 NET-EN (84-day) subjects were observed for 10,331 woman-months. This clinical trial represents the largest clinical trial undertaken on injectable contraceptives. After two years, the pregnancy rate with NET-EN (84-day) was 1.4 (±0.6 S.E.) per 100 women, as compared with the two-year rates of 0.4 (±0.3 S.E.) per 100 women observed with DMPA and 0.4 (± 0.2 S.E.) with NET-EN (60-day). Both discontinuation rates for amenorrhea and the prevalence of amenorrhea lasting more than 90 days were significantly higher with DMPA than with either NET-EN regimen. Terminations for bleeding problems were similar with the three treatments, despite a better cyclic pattern for the first six months with the NET-EN regimens. The three treatments were comparable with respect to discontinuation rates for other medical or personal reasons, and for all reasons combined. For family planning programs, NET-EN (60-day) has the advantage of low pregnancy rates compared to NET-EN (84-day), and a schedule of administration that does not change. Both NET-EN regimens produce less amenorrhea than DMPA. However, the NET-EN (60-day) regimen has the logistic and economic disadvantage of requiring more frequent injections. All three injectable regimens compare favourably with oral contraceptives in terms of pregnancy and total continuation rates observed in clinical trial settings.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-25T17:56:49Z No. of bitstreams: 1 111111.pdf: 1183752 bytes, checksum: d6ea5b6df85dd562fc9ffcac5154ec7f (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-30T17:46:58Z (GMT) No. of bitstreams: 1 111111.pdf: 1183752 bytes, checksum: d6ea5b6df85dd562fc9ffcac5154ec7f (MD5)Made available in DSpace on 2013-10-30T17:46:58Z (GMT). No. of bitstreams: 1 111111.pdf: 1183752 bytes, checksum: d6ea5b6df85dd562fc9ffcac5154ec7f (MD5) Previous issue date: 1983SalvadorContraceptionhttp://www-sciencedirect-com.ez10.periodicos.capes.gov.br/science/article/pii/S001078248380002Xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMultinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproductionContraceptioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL111111.pdf111111.pdfapplication/pdf1183752https://repositorio.ufba.br/bitstream/ri/13332/1/111111.pdfd6ea5b6df85dd562fc9ffcac5154ec7fMD51LICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13332/2/license.txt5371a150bdc863f78dcf39281543bd86MD52TEXT111111.pdf.txt111111.pdf.txtExtracted texttext/plain31601https://repositorio.ufba.br/bitstream/ri/13332/3/111111.pdf.txt2b27c848da3ed320ca4e616834335cc3MD53ri/133322022-07-01 10:46:54.094oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-01T13:46:54Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
dc.title.alternative.pt_BR.fl_str_mv Contraception
title Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
spellingShingle Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
Souza, J. Caetano de
title_short Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
title_full Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
title_fullStr Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
title_full_unstemmed Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
title_sort Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report *: Who special programme of research, development and research training in human reproduction
author Souza, J. Caetano de
author_facet Souza, J. Caetano de
Toppozada, H. K.
Koetsawang, S.
Aimakhu, V. E.
Khan, T.
Pretnar-Darovec, A.
Chatterjee, T. K.
Molitor-Peffer, M. P.
Apelo, R.
Lichtenberg, R.
Crosignani, P. G.
Huidubro, M. Garcia
Haspels, A. A.
Annus, J.
Benaginao, G.
Diethelm, P.
Gray, R.
Hall, P. E.
Holck, S. E.
author_role author
author2 Toppozada, H. K.
Koetsawang, S.
Aimakhu, V. E.
Khan, T.
Pretnar-Darovec, A.
Chatterjee, T. K.
Molitor-Peffer, M. P.
Apelo, R.
Lichtenberg, R.
Crosignani, P. G.
Huidubro, M. Garcia
Haspels, A. A.
Annus, J.
Benaginao, G.
Diethelm, P.
Gray, R.
Hall, P. E.
Holck, S. E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, J. Caetano de
Toppozada, H. K.
Koetsawang, S.
Aimakhu, V. E.
Khan, T.
Pretnar-Darovec, A.
Chatterjee, T. K.
Molitor-Peffer, M. P.
Apelo, R.
Lichtenberg, R.
Crosignani, P. G.
Huidubro, M. Garcia
Haspels, A. A.
Annus, J.
Benaginao, G.
Diethelm, P.
Gray, R.
Hall, P. E.
Holck, S. E.
description Texto completo. Acesso restrito. p. 1–20
publishDate 1983
dc.date.issued.fl_str_mv 1983
dc.date.accessioned.fl_str_mv 2013-10-30T17:46:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13332
dc.identifier.issn.none.fl_str_mv 0010-7824
dc.identifier.number.pt_BR.fl_str_mv v. 28, n. 1
identifier_str_mv 0010-7824
v. 28, n. 1
url http://repositorio.ufba.br/ri/handle/ri/13332
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Contraception
publisher.none.fl_str_mv Contraception
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