The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide

Detalhes bibliográficos
Autor(a) principal: Salvadori, Daisy M. F.
Data de Publicação: 1992
Outros Autores: Ribeiro, Lúcia R., Oliveira, Marília de Dirceu Machado de, Pereira, Carlos A. B., Beçak, Willy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13523
Resumo: Texto completo. Acesso restrito. p. 237–244
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spelling Salvadori, Daisy M. F.Ribeiro, Lúcia R.Oliveira, Marília de Dirceu Machado dePereira, Carlos A. B.Beçak, WillySalvadori, Daisy M. F.Ribeiro, Lúcia R.Oliveira, Marília de Dirceu Machado dePereira, Carlos A. B.Beçak, Willy2013-11-03T14:00:33Z19920027-5107http://repositorio.ufba.br/ri/handle/ri/13523v. 265, n. 2Texto completo. Acesso restrito. p. 237–244The influence of ß-carotene on the clastogenicity of the indirect-acting mutagen cyclophosphamide (CPA) was investigated in mice, in vivo, for the induction of chromosome aberrations in bone marrow cells (BM). ß-Carotene (0.5, 1.0, 2.0, 5.0, 10, 25, 50, 100 and 200 mg/kg) was administered by gavage for 5 consecutive days. 4 h after the last treatment with ß-carotene, the mice were injected intraperitoneally with CPA, and the BM cells were fixed after 16, 24 and 32 h for the evaluation of the frequency of chromosome aberrations. The results showed that ß-carotene was effective in reducing chromosomal damage induced by CPA with the increase of its concentration up to a level after which this effect was not observed. This anticlastogenicity was better detected when the cells were fixed at 32 h, although a tendency in reducing the CPA clastogenicity was already observed at 16 and 24 h. Our results suggest that ß-carotene provides significant protection against the genotoxicity of CPA, although no dose-effect relationship on the frequencies of cells with chromosomal aberrations was observed.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-18T19:38:18Z No. of bitstreams: 1 55555555555555555.pdf: 527205 bytes, checksum: 4299d6d212fbdfdca24d13da7948022f (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-03T14:00:32Z (GMT) No. of bitstreams: 1 55555555555555555.pdf: 527205 bytes, checksum: 4299d6d212fbdfdca24d13da7948022f (MD5)Made available in DSpace on 2013-11-03T14:00:33Z (GMT). No. of bitstreams: 1 55555555555555555.pdf: 527205 bytes, checksum: 4299d6d212fbdfdca24d13da7948022f (MD5) Previous issue date: 1992SalvadorMutation Research - Fundamental and Molecular Mechanisms of Mutagenesishttp://www-sciencedirect-com.ez10.periodicos.capes.gov.br/science/article/pii/0027510792900524reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAntimutagenesisß-CaroteneChromosome aberrationCyclophosphamideThe protective effect of ß-carotene on genotoxicity induced by cyclophosphamideMutation Research - Fundamental and Molecular Mechanisms of Mutagenesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13523/2/license.txt5371a150bdc863f78dcf39281543bd86MD52ORIGINAL55555555555555555.pdf55555555555555555.pdfapplication/pdf527205https://repositorio.ufba.br/bitstream/ri/13523/1/55555555555555555.pdf4299d6d212fbdfdca24d13da7948022fMD51TEXT55555555555555555.pdf.txt55555555555555555.pdf.txtExtracted texttext/plain24197https://repositorio.ufba.br/bitstream/ri/13523/3/55555555555555555.pdf.txtdfb47bdeef42b0753e20e86f63309187MD53ri/135232022-07-05 14:02:48.109oai:repositorio.ufba.br:ri/13523Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
dc.title.alternative.pt_BR.fl_str_mv Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
title The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
spellingShingle The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
Salvadori, Daisy M. F.
Antimutagenesis
ß-Carotene
Chromosome aberration
Cyclophosphamide
title_short The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
title_full The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
title_fullStr The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
title_full_unstemmed The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
title_sort The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide
author Salvadori, Daisy M. F.
author_facet Salvadori, Daisy M. F.
Ribeiro, Lúcia R.
Oliveira, Marília de Dirceu Machado de
Pereira, Carlos A. B.
Beçak, Willy
author_role author
author2 Ribeiro, Lúcia R.
Oliveira, Marília de Dirceu Machado de
Pereira, Carlos A. B.
Beçak, Willy
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Salvadori, Daisy M. F.
Ribeiro, Lúcia R.
Oliveira, Marília de Dirceu Machado de
Pereira, Carlos A. B.
Beçak, Willy
Salvadori, Daisy M. F.
Ribeiro, Lúcia R.
Oliveira, Marília de Dirceu Machado de
Pereira, Carlos A. B.
Beçak, Willy
dc.subject.por.fl_str_mv Antimutagenesis
ß-Carotene
Chromosome aberration
Cyclophosphamide
topic Antimutagenesis
ß-Carotene
Chromosome aberration
Cyclophosphamide
description Texto completo. Acesso restrito. p. 237–244
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2013-11-03T14:00:33Z
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13523
dc.identifier.issn.none.fl_str_mv 0027-5107
dc.identifier.number.pt_BR.fl_str_mv v. 265, n. 2
identifier_str_mv 0027-5107
v. 265, n. 2
url http://repositorio.ufba.br/ri/handle/ri/13523
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
publisher.none.fl_str_mv Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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