Nonalcoholic fatty liver disease in menopausal women

Detalhes bibliográficos
Autor(a) principal: Florentino, Gesira Soares de Assis
Data de Publicação: 2013
Outros Autores: Cotrim, Helma Pinchemel, Salvador, Consuelo Padilha Vilar, Florentino, André Vinícius de Assis, Guimarães, Geruza Maria Almeida, Barreto, Victorino Spinelli Toscano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15056
Resumo: p. 180-185
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spelling Florentino, Gesira Soares de AssisCotrim, Helma PinchemelSalvador, Consuelo Padilha VilarFlorentino, André Vinícius de AssisGuimarães, Geruza Maria AlmeidaBarreto, Victorino Spinelli ToscanoFlorentino, Gesira Soares de AssisCotrim, Helma PinchemelSalvador, Consuelo Padilha VilarFlorentino, André Vinícius de AssisGuimarães, Geruza Maria AlmeidaBarreto, Victorino Spinelli Toscano2014-06-05T16:23:46Z2014-06-05T16:23:46Z20130004-2803http://repositorio.ufba.br/ri/handle/ri/15056v. 50, n. 3p. 180-185Context: Nonalcoholic Fatty Liver Disease (NAFLD) is common in postmenopausal women. It is associated with metabolic syndrome. However, the influence of hormone replacement therapy in NAFLD development in these women needs to be investigated. This study aimed to describe the clinical characteristics of NAFLD in postmenopausal women, and the relationship between hormone replacement therapy and this disease. Methods: From April 2009 to April 2011, 292 postmenopausal women from National Health System from Northeast of Brazil were selected, and 251 were included in this study. Menopause was defined as the absence of menstruation for 12 consecutive months in otherwise healthy women. Criteria to NAFLD included: presence of steatosis on abdominal ultrasound; history of alcohol consumption less than 20 g/day and exclusion of other liver diseases. All women underwent a clinical evaluation. Standard univariate and multivariate analyses were performed to evaluate the results. Results: The mean age was 56.5 ± 6.7 years. Hormone replacement therapy was referred by 21.1% (53) women and 78.9% (198) was not. Prevalence of NAFLD was 37.1% (93/251) in postmenopausal women, 26,4% (14/53) in the group with hormone replacement therapy and 39,9% (79/198) without hormone replacement therapy. Gamma-glutamyl transpeptidase (P = 0.001), alanine transaminase (P<0.01), ferritin (P<0.001) and insulin resistance (homeostatic model assessment of insulin resistance ≥3) (P<0.001) were higher in the group of women with NAFLD diagnosis who did not referred the use of hormone replacement therapy. Metabolic syndrome was also more frequent in women with NAFLD, who did not refer hormone replacement therapy. Conclusion: In conclusion this data suggests elevated prevalence of NAFLD in postmenopausal women; negative association of hormone replacement therapy and NAFLD.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-22T16:41:01Z No. of bitstreams: 1 0004-2803-ag-50-03-180.pdf: 163423 bytes, checksum: 5eb2c26671127e103a6dab6883568ac2 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-05T16:23:46Z (GMT) No. of bitstreams: 1 0004-2803-ag-50-03-180.pdf: 163423 bytes, checksum: 5eb2c26671127e103a6dab6883568ac2 (MD5)Made available in DSpace on 2014-06-05T16:23:46Z (GMT). No. of bitstreams: 1 0004-2803-ag-50-03-180.pdf: 163423 bytes, checksum: 5eb2c26671127e103a6dab6883568ac2 (MD5) Previous issue date: 2013http://dx.doi.org/10.1590/S0004-28032013000200032reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAFatty liverHormone replacement therapyMenopauseEthanolInsulin resistanceNonalcoholic fatty liver disease in menopausal womenArquivos de Gastroenterologiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15056/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL0004-2803-ag-50-03-180.pdf0004-2803-ag-50-03-180.pdfapplication/pdf163423https://repositorio.ufba.br/bitstream/ri/15056/1/0004-2803-ag-50-03-180.pdf5eb2c26671127e103a6dab6883568ac2MD51TEXT0004-2803-ag-50-03-180.pdf.txt0004-2803-ag-50-03-180.pdf.txtExtracted texttext/plain29901https://repositorio.ufba.br/bitstream/ri/15056/3/0004-2803-ag-50-03-180.pdf.txt776e573ae8dfb3b027bffa2625476c18MD53ri/150562022-08-08 13:18:01.649oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Nonalcoholic fatty liver disease in menopausal women
dc.title.alternative.pt_BR.fl_str_mv Arquivos de Gastroenterologia
title Nonalcoholic fatty liver disease in menopausal women
spellingShingle Nonalcoholic fatty liver disease in menopausal women
Florentino, Gesira Soares de Assis
Fatty liver
Hormone replacement therapy
Menopause
Ethanol
Insulin resistance
title_short Nonalcoholic fatty liver disease in menopausal women
title_full Nonalcoholic fatty liver disease in menopausal women
title_fullStr Nonalcoholic fatty liver disease in menopausal women
title_full_unstemmed Nonalcoholic fatty liver disease in menopausal women
title_sort Nonalcoholic fatty liver disease in menopausal women
author Florentino, Gesira Soares de Assis
author_facet Florentino, Gesira Soares de Assis
Cotrim, Helma Pinchemel
Salvador, Consuelo Padilha Vilar
Florentino, André Vinícius de Assis
Guimarães, Geruza Maria Almeida
Barreto, Victorino Spinelli Toscano
author_role author
author2 Cotrim, Helma Pinchemel
Salvador, Consuelo Padilha Vilar
Florentino, André Vinícius de Assis
Guimarães, Geruza Maria Almeida
Barreto, Victorino Spinelli Toscano
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Florentino, Gesira Soares de Assis
Cotrim, Helma Pinchemel
Salvador, Consuelo Padilha Vilar
Florentino, André Vinícius de Assis
Guimarães, Geruza Maria Almeida
Barreto, Victorino Spinelli Toscano
Florentino, Gesira Soares de Assis
Cotrim, Helma Pinchemel
Salvador, Consuelo Padilha Vilar
Florentino, André Vinícius de Assis
Guimarães, Geruza Maria Almeida
Barreto, Victorino Spinelli Toscano
dc.subject.por.fl_str_mv Fatty liver
Hormone replacement therapy
Menopause
Ethanol
Insulin resistance
topic Fatty liver
Hormone replacement therapy
Menopause
Ethanol
Insulin resistance
description p. 180-185
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-06-05T16:23:46Z
dc.date.available.fl_str_mv 2014-06-05T16:23:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15056
dc.identifier.issn.none.fl_str_mv 0004-2803
dc.identifier.number.pt_BR.fl_str_mv v. 50, n. 3
identifier_str_mv 0004-2803
v. 50, n. 3
url http://repositorio.ufba.br/ri/handle/ri/15056
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0004-28032013000200032
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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