Nonalcoholic fatty liver disease in menopausal women
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15056 |
Resumo: | p. 180-185 |
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Florentino, Gesira Soares de AssisCotrim, Helma PinchemelSalvador, Consuelo Padilha VilarFlorentino, André Vinícius de AssisGuimarães, Geruza Maria AlmeidaBarreto, Victorino Spinelli ToscanoFlorentino, Gesira Soares de AssisCotrim, Helma PinchemelSalvador, Consuelo Padilha VilarFlorentino, André Vinícius de AssisGuimarães, Geruza Maria AlmeidaBarreto, Victorino Spinelli Toscano2014-06-05T16:23:46Z2014-06-05T16:23:46Z20130004-2803http://repositorio.ufba.br/ri/handle/ri/15056v. 50, n. 3p. 180-185Context: Nonalcoholic Fatty Liver Disease (NAFLD) is common in postmenopausal women. It is associated with metabolic syndrome. However, the influence of hormone replacement therapy in NAFLD development in these women needs to be investigated. This study aimed to describe the clinical characteristics of NAFLD in postmenopausal women, and the relationship between hormone replacement therapy and this disease. Methods: From April 2009 to April 2011, 292 postmenopausal women from National Health System from Northeast of Brazil were selected, and 251 were included in this study. Menopause was defined as the absence of menstruation for 12 consecutive months in otherwise healthy women. Criteria to NAFLD included: presence of steatosis on abdominal ultrasound; history of alcohol consumption less than 20 g/day and exclusion of other liver diseases. All women underwent a clinical evaluation. Standard univariate and multivariate analyses were performed to evaluate the results. Results: The mean age was 56.5 ± 6.7 years. Hormone replacement therapy was referred by 21.1% (53) women and 78.9% (198) was not. Prevalence of NAFLD was 37.1% (93/251) in postmenopausal women, 26,4% (14/53) in the group with hormone replacement therapy and 39,9% (79/198) without hormone replacement therapy. Gamma-glutamyl transpeptidase (P = 0.001), alanine transaminase (P<0.01), ferritin (P<0.001) and insulin resistance (homeostatic model assessment of insulin resistance ≥3) (P<0.001) were higher in the group of women with NAFLD diagnosis who did not referred the use of hormone replacement therapy. Metabolic syndrome was also more frequent in women with NAFLD, who did not refer hormone replacement therapy. Conclusion: In conclusion this data suggests elevated prevalence of NAFLD in postmenopausal women; negative association of hormone replacement therapy and NAFLD.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-22T16:41:01Z No. of bitstreams: 1 0004-2803-ag-50-03-180.pdf: 163423 bytes, checksum: 5eb2c26671127e103a6dab6883568ac2 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-05T16:23:46Z (GMT) No. of bitstreams: 1 0004-2803-ag-50-03-180.pdf: 163423 bytes, checksum: 5eb2c26671127e103a6dab6883568ac2 (MD5)Made available in DSpace on 2014-06-05T16:23:46Z (GMT). No. of bitstreams: 1 0004-2803-ag-50-03-180.pdf: 163423 bytes, checksum: 5eb2c26671127e103a6dab6883568ac2 (MD5) Previous issue date: 2013http://dx.doi.org/10.1590/S0004-28032013000200032reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAFatty liverHormone replacement therapyMenopauseEthanolInsulin resistanceNonalcoholic fatty liver disease in menopausal womenArquivos de Gastroenterologiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15056/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL0004-2803-ag-50-03-180.pdf0004-2803-ag-50-03-180.pdfapplication/pdf163423https://repositorio.ufba.br/bitstream/ri/15056/1/0004-2803-ag-50-03-180.pdf5eb2c26671127e103a6dab6883568ac2MD51TEXT0004-2803-ag-50-03-180.pdf.txt0004-2803-ag-50-03-180.pdf.txtExtracted texttext/plain29901https://repositorio.ufba.br/bitstream/ri/15056/3/0004-2803-ag-50-03-180.pdf.txt776e573ae8dfb3b027bffa2625476c18MD53ri/150562022-08-08 13:18:01.649oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Nonalcoholic fatty liver disease in menopausal women |
dc.title.alternative.pt_BR.fl_str_mv |
Arquivos de Gastroenterologia |
title |
Nonalcoholic fatty liver disease in menopausal women |
spellingShingle |
Nonalcoholic fatty liver disease in menopausal women Florentino, Gesira Soares de Assis Fatty liver Hormone replacement therapy Menopause Ethanol Insulin resistance |
title_short |
Nonalcoholic fatty liver disease in menopausal women |
title_full |
Nonalcoholic fatty liver disease in menopausal women |
title_fullStr |
Nonalcoholic fatty liver disease in menopausal women |
title_full_unstemmed |
Nonalcoholic fatty liver disease in menopausal women |
title_sort |
Nonalcoholic fatty liver disease in menopausal women |
author |
Florentino, Gesira Soares de Assis |
author_facet |
Florentino, Gesira Soares de Assis Cotrim, Helma Pinchemel Salvador, Consuelo Padilha Vilar Florentino, André Vinícius de Assis Guimarães, Geruza Maria Almeida Barreto, Victorino Spinelli Toscano |
author_role |
author |
author2 |
Cotrim, Helma Pinchemel Salvador, Consuelo Padilha Vilar Florentino, André Vinícius de Assis Guimarães, Geruza Maria Almeida Barreto, Victorino Spinelli Toscano |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Florentino, Gesira Soares de Assis Cotrim, Helma Pinchemel Salvador, Consuelo Padilha Vilar Florentino, André Vinícius de Assis Guimarães, Geruza Maria Almeida Barreto, Victorino Spinelli Toscano Florentino, Gesira Soares de Assis Cotrim, Helma Pinchemel Salvador, Consuelo Padilha Vilar Florentino, André Vinícius de Assis Guimarães, Geruza Maria Almeida Barreto, Victorino Spinelli Toscano |
dc.subject.por.fl_str_mv |
Fatty liver Hormone replacement therapy Menopause Ethanol Insulin resistance |
topic |
Fatty liver Hormone replacement therapy Menopause Ethanol Insulin resistance |
description |
p. 180-185 |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-06-05T16:23:46Z |
dc.date.available.fl_str_mv |
2014-06-05T16:23:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
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http://repositorio.ufba.br/ri/handle/ri/15056 |
dc.identifier.issn.none.fl_str_mv |
0004-2803 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 50, n. 3 |
identifier_str_mv |
0004-2803 v. 50, n. 3 |
url |
http://repositorio.ufba.br/ri/handle/ri/15056 |
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eng |
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eng |
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Brasil |
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http://dx.doi.org/10.1590/S0004-28032013000200032 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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Repositório Institucional da UFBA |
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Repositório Institucional da UFBA |
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