Risk of fatal adverse events associated with 17DD yellow fever vaccine

Detalhes bibliográficos
Autor(a) principal: Struchiner, Claudio José
Data de Publicação: 2004
Outros Autores: Luz, Paula Mendes, Dourado, Maria Inês Costa, Sato, Hédison Kiuity, Aguiar, S. G., Ribeiro, José Geraldo Leite, Soares, Rosa Castália França Ribeiro, Codeço, Cláudia Torres
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7132
Resumo: p. 939-946
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spelling Struchiner, Claudio JoséLuz, Paula MendesDourado, Maria Inês CostaSato, Hédison KiuityAguiar, S. G.Ribeiro, José Geraldo LeiteSoares, Rosa Castália França RibeiroCodeço, Cláudia TorresStruchiner, Claudio JoséLuz, Paula MendesDourado, Maria Inês CostaSato, Hédison KiuityAguiar, S. G.Ribeiro, José Geraldo LeiteSoares, Rosa Castália França RibeiroCodeço, Cláudia Torres2012-11-07T13:21:50Z20040950-2688http://www.repositorio.ufba.br/ri/handle/ri/7132v. 132, n. 5p. 939-946Yellow fever (YF), an acute infectious disease, is endemic in the north and central-west of Brazil. This disease can be prevented by the use of a vaccine. In Brazil, four fatal adverse events have been associated with the YF vaccine used in the country (17DD vaccine). We briefly describe the last two fatalities, and estimate the risk of 17DD-associated fatal adverse events under different epidemiological scenarios. Controversies regarding the appropriate denominator that enters the estimation of risk serve as a motivation for each proposed scenario. The statistical procedures used show optimum behaviour when assessing the risk of rare events. Risk estimates vary from 0.043 (95% CI 0.017–0.110) to 2.131 (95% CI 0.109–12.071) fatalities per million doses administered. The robust estimates of the risk of fatal adverse events we present constitute an important element in future risk–benefit analysis and point to the need for good quality vaccine coverage and adverse-events surveillance data to assess the risk of vaccination. Although vaccination of YF endemic regions is necessary to maintain low disease prevalence, preventive administration of YF vaccine to the entire population should be cautiously analysed.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-11-07T13:21:50Z No. of bitstreams: 1 plugin-download.php.pdf: 198427 bytes, checksum: f763d0761c2726b85e0cece090547504 (MD5)Made available in DSpace on 2012-11-07T13:21:50Z (GMT). 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dc.title.pt_BR.fl_str_mv Risk of fatal adverse events associated with 17DD yellow fever vaccine
dc.title.alternative.pt_BR.fl_str_mv Epidemiology and Infection
title Risk of fatal adverse events associated with 17DD yellow fever vaccine
spellingShingle Risk of fatal adverse events associated with 17DD yellow fever vaccine
Struchiner, Claudio José
title_short Risk of fatal adverse events associated with 17DD yellow fever vaccine
title_full Risk of fatal adverse events associated with 17DD yellow fever vaccine
title_fullStr Risk of fatal adverse events associated with 17DD yellow fever vaccine
title_full_unstemmed Risk of fatal adverse events associated with 17DD yellow fever vaccine
title_sort Risk of fatal adverse events associated with 17DD yellow fever vaccine
author Struchiner, Claudio José
author_facet Struchiner, Claudio José
Luz, Paula Mendes
Dourado, Maria Inês Costa
Sato, Hédison Kiuity
Aguiar, S. G.
Ribeiro, José Geraldo Leite
Soares, Rosa Castália França Ribeiro
Codeço, Cláudia Torres
author_role author
author2 Luz, Paula Mendes
Dourado, Maria Inês Costa
Sato, Hédison Kiuity
Aguiar, S. G.
Ribeiro, José Geraldo Leite
Soares, Rosa Castália França Ribeiro
Codeço, Cláudia Torres
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Struchiner, Claudio José
Luz, Paula Mendes
Dourado, Maria Inês Costa
Sato, Hédison Kiuity
Aguiar, S. G.
Ribeiro, José Geraldo Leite
Soares, Rosa Castália França Ribeiro
Codeço, Cláudia Torres
Struchiner, Claudio José
Luz, Paula Mendes
Dourado, Maria Inês Costa
Sato, Hédison Kiuity
Aguiar, S. G.
Ribeiro, José Geraldo Leite
Soares, Rosa Castália França Ribeiro
Codeço, Cláudia Torres
description p. 939-946
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-11-07T13:21:50Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7132
dc.identifier.issn.none.fl_str_mv 0950-2688
dc.identifier.number.pt_BR.fl_str_mv v. 132, n. 5
identifier_str_mv 0950-2688
v. 132, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/7132
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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