Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population

Detalhes bibliográficos
Autor(a) principal: Gaze, S. T.
Data de Publicação: 2006
Outros Autores: Dutra, Walderez Ornelas, Lessa, M., Lessa, Hélio Andrade, Guimarães, L. H., Jesus, A. R. de, Carvalho, Lain Carlos Pontes de, Machado, Paulo Roberto Lima, Carvalho Filho, Edgar Marcelino de, Gollob, K. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13646
Resumo: Texto completo: acesso restrito. p. 70–78
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spelling Gaze, S. T.Dutra, Walderez OrnelasLessa, M.Lessa, Hélio AndradeGuimarães, L. H.Jesus, A. R. deCarvalho, Lain Carlos Pontes deMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deGollob, K. J.Gaze, S. T.Dutra, Walderez OrnelasLessa, M.Lessa, Hélio AndradeGuimarães, L. H.Jesus, A. R. deCarvalho, Lain Carlos Pontes deMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deGollob, K. J.2013-11-14T20:06:20Z20060300-9475http://repositorio.ufba.br/ri/handle/ri/13646v. 63, n. 1Texto completo: acesso restrito. p. 70–78Leishmania braziliensis is a parasite that can induce at least two clinical forms of leishmaniasis in humans: cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML). In humans, the specific mechanisms that determine which form will develop following infection are not well established. In this study, peripheral blood mononuclear cells from 17 CL and 9 ml patients were compared both ex vivo and after culture with soluble leishmania antigen (SLA). Patients with ML presented a higher frequency of activated T cells as measured by ex vivo frequencies of CD4+CD69+, CD4+CD28–, CD4+CD62L– and CD8+CD69+ than those with CL. Moreover, after stimulation with SLA, patients with ML presented a higher frequency of TNF-α-producing CD4+ and CD14+ cells than CL individuals. While CL patients displayed a positive correlation between the frequency of IL-10 and TNF-α-producing monocytes, the ML patients did not. This lack of a positive correlation between IL-10-producing and TNF-α-producing monocytes in ML patients could lead to a less controlled inflammatory response in vivo. These results corroborate with a model of an exacerbated, unregulated, immune response in ML patients and point to key immunomodulatory leucocyte populations and cytokine networks that may be involved in the development of immunopathology in ML patients.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-05T15:33:10Z No. of bitstreams: 1 j.1365-3083.2005.01707.x.pdf: 413974 bytes, checksum: 40f335d0f7b10419ad0cd38fc6a9e31f (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-14T20:06:20Z (GMT) No. of bitstreams: 1 j.1365-3083.2005.01707.x.pdf: 413974 bytes, checksum: 40f335d0f7b10419ad0cd38fc6a9e31f (MD5)Made available in DSpace on 2013-11-14T20:06:20Z (GMT). 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dc.title.pt_BR.fl_str_mv Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
dc.title.alternative.pt_BR.fl_str_mv Scandinavian Journal of Immunology
title Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
spellingShingle Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
Gaze, S. T.
title_short Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
title_full Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
title_fullStr Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
title_full_unstemmed Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
title_sort Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population
author Gaze, S. T.
author_facet Gaze, S. T.
Dutra, Walderez Ornelas
Lessa, M.
Lessa, Hélio Andrade
Guimarães, L. H.
Jesus, A. R. de
Carvalho, Lain Carlos Pontes de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
author_role author
author2 Dutra, Walderez Ornelas
Lessa, M.
Lessa, Hélio Andrade
Guimarães, L. H.
Jesus, A. R. de
Carvalho, Lain Carlos Pontes de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gaze, S. T.
Dutra, Walderez Ornelas
Lessa, M.
Lessa, Hélio Andrade
Guimarães, L. H.
Jesus, A. R. de
Carvalho, Lain Carlos Pontes de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
Gaze, S. T.
Dutra, Walderez Ornelas
Lessa, M.
Lessa, Hélio Andrade
Guimarães, L. H.
Jesus, A. R. de
Carvalho, Lain Carlos Pontes de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
description Texto completo: acesso restrito. p. 70–78
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-11-14T20:06:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13646
dc.identifier.issn.none.fl_str_mv 0300-9475
dc.identifier.number.pt_BR.fl_str_mv v. 63, n. 1
identifier_str_mv 0300-9475
v. 63, n. 1
url http://repositorio.ufba.br/ri/handle/ri/13646
dc.language.iso.fl_str_mv eng
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