Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study

Detalhes bibliográficos
Autor(a) principal: Lyra, André Castro
Data de Publicação: 2010
Outros Autores: Soares, Milena Botelho Pereira, Silva, Luiz Flavio Maia da, Braga, Eduardo Lorens, Oliveira, Sheilla A., Fortes, Marcos Fraga, Silva, Andre Goyanna Pinheiro, Brustolim, Daniele, Genser, Bernd, Santos, Ricardo Ribeiro dos, Lyra, Luiz Guilherme Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13402
Resumo: Texto completo: acesso restrito. p.33-42
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spelling Lyra, André CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daBraga, Eduardo LorensOliveira, Sheilla A.Fortes, Marcos FragaSilva, Andre Goyanna PinheiroBrustolim, DanieleGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme CostaLyra, André CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daBraga, Eduardo LorensOliveira, Sheilla A.Fortes, Marcos FragaSilva, Andre Goyanna PinheiroBrustolim, DanieleGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme Costa2013-10-31T17:42:53Z20100954-691Xhttp://repositorio.ufba.br/ri/handle/ri/13402v. 22, n. 1Texto completo: acesso restrito. p.33-42Aim: This randomized controlled study evaluated the effect of autologous infusion of bone marrow cells (BMC) in patients with hepatic cirrhosis. Methods: Thirty patients on the liver transplant waiting list were randomly assigned to receive BMC therapy or no treatment. They were followed up for 1 year. The study was nonblinded. Autologous mononuclear-enriched BMC were infused into the hepatic artery; liver function scores/tests were chosen as endpoints to assess efficacy. Statistical analysis calculated mean relative changes (RC) from baseline and fitted a random-effects model. Results: Mean age, baseline model for end-stage liver disease, and Child–Pugh score were similar in both groups. Child–Pugh score improved in the first 90 days in the cell therapy group compared with controls (P = 0.017, BMC group RC = -8%, controls RC = +5%). The model for end-stage liver disease score remained stable in the treated patients (RC -2 to +6%), whereas it increased during follow-up in the control group (RC +6 to +18%). Albumin levels improved in the treatment arm, whereas they remained stable among controls in the first 90 days (P = 0.034; BMC group RC = +16%, control group RC = +2%). Bilirubin levels increased among controls, whereas they decreased in the therapy arm during the first 60 days; INR RC differences between groups reached up to 10%. The changes observed did not persist beyond 90 days. Conclusion: Transplantation of autologous BMC into the hepatic artery improved liver function in patients with advanced cirrhosis in the first 90 days. However, larger studies are necessary to define the role of BMC therapy in cirrhotic patients. Repeated autologous BMC infusions or combination therapy with granulocyte-colony-stimulating factor might improve or sustain the treatment response.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-09-11T13:49:45Z No. of bitstreams: 1 00042737-201001000-00005.pdf: 262144 bytes, checksum: cd90401cc93bb9cd48cc317c3f9d7f97 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:42:53Z (GMT) No. of bitstreams: 1 00042737-201001000-00005.pdf: 262144 bytes, checksum: cd90401cc93bb9cd48cc317c3f9d7f97 (MD5)Made available in DSpace on 2013-10-31T17:42:53Z (GMT). No. of bitstreams: 1 00042737-201001000-00005.pdf: 262144 bytes, checksum: cd90401cc93bb9cd48cc317c3f9d7f97 (MD5) Previous issue date: 2010http://dx.doi.org/10.1097/MEG.0b013e32832eb69areponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABone marrow stem cell transplantationCD34Cell therapyChronic liver diseaseCirrhosisInfusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled studyEuropean Journal of Gastroenterology and Hepatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL00042737-201001000-00005.pdf00042737-201001000-00005.pdfapplication/pdf262144https://repositorio.ufba.br/bitstream/ri/13402/1/00042737-201001000-00005.pdfcd90401cc93bb9cd48cc317c3f9d7f97MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13402/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT00042737-201001000-00005.pdf.txt00042737-201001000-00005.pdf.txtExtracted texttext/plain41359https://repositorio.ufba.br/bitstream/ri/13402/3/00042737-201001000-00005.pdf.txt3ffdf473166ac82db0e175c107cc420dMD53ri/134022022-07-05 14:02:57.276oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:57Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
dc.title.alternative.pt_BR.fl_str_mv European Journal of Gastroenterology and Hepatology
title Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
spellingShingle Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
Lyra, André Castro
Bone marrow stem cell transplantation
CD34
Cell therapy
Chronic liver disease
Cirrhosis
title_short Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
title_full Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
title_fullStr Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
title_full_unstemmed Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
title_sort Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
author Lyra, André Castro
author_facet Lyra, André Castro
Soares, Milena Botelho Pereira
Silva, Luiz Flavio Maia da
Braga, Eduardo Lorens
Oliveira, Sheilla A.
Fortes, Marcos Fraga
Silva, Andre Goyanna Pinheiro
Brustolim, Daniele
Genser, Bernd
Santos, Ricardo Ribeiro dos
Lyra, Luiz Guilherme Costa
author_role author
author2 Soares, Milena Botelho Pereira
Silva, Luiz Flavio Maia da
Braga, Eduardo Lorens
Oliveira, Sheilla A.
Fortes, Marcos Fraga
Silva, Andre Goyanna Pinheiro
Brustolim, Daniele
Genser, Bernd
Santos, Ricardo Ribeiro dos
Lyra, Luiz Guilherme Costa
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lyra, André Castro
Soares, Milena Botelho Pereira
Silva, Luiz Flavio Maia da
Braga, Eduardo Lorens
Oliveira, Sheilla A.
Fortes, Marcos Fraga
Silva, Andre Goyanna Pinheiro
Brustolim, Daniele
Genser, Bernd
Santos, Ricardo Ribeiro dos
Lyra, Luiz Guilherme Costa
Lyra, André Castro
Soares, Milena Botelho Pereira
Silva, Luiz Flavio Maia da
Braga, Eduardo Lorens
Oliveira, Sheilla A.
Fortes, Marcos Fraga
Silva, Andre Goyanna Pinheiro
Brustolim, Daniele
Genser, Bernd
Santos, Ricardo Ribeiro dos
Lyra, Luiz Guilherme Costa
dc.subject.por.fl_str_mv Bone marrow stem cell transplantation
CD34
Cell therapy
Chronic liver disease
Cirrhosis
topic Bone marrow stem cell transplantation
CD34
Cell therapy
Chronic liver disease
Cirrhosis
description Texto completo: acesso restrito. p.33-42
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-10-31T17:42:53Z
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13402
dc.identifier.issn.none.fl_str_mv 0954-691X
dc.identifier.number.pt_BR.fl_str_mv v. 22, n. 1
identifier_str_mv 0954-691X
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