Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13402 |
Resumo: | Texto completo: acesso restrito. p.33-42 |
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Lyra, André CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daBraga, Eduardo LorensOliveira, Sheilla A.Fortes, Marcos FragaSilva, Andre Goyanna PinheiroBrustolim, DanieleGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme CostaLyra, André CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daBraga, Eduardo LorensOliveira, Sheilla A.Fortes, Marcos FragaSilva, Andre Goyanna PinheiroBrustolim, DanieleGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme Costa2013-10-31T17:42:53Z20100954-691Xhttp://repositorio.ufba.br/ri/handle/ri/13402v. 22, n. 1Texto completo: acesso restrito. p.33-42Aim: This randomized controlled study evaluated the effect of autologous infusion of bone marrow cells (BMC) in patients with hepatic cirrhosis. Methods: Thirty patients on the liver transplant waiting list were randomly assigned to receive BMC therapy or no treatment. They were followed up for 1 year. The study was nonblinded. Autologous mononuclear-enriched BMC were infused into the hepatic artery; liver function scores/tests were chosen as endpoints to assess efficacy. Statistical analysis calculated mean relative changes (RC) from baseline and fitted a random-effects model. Results: Mean age, baseline model for end-stage liver disease, and Child–Pugh score were similar in both groups. Child–Pugh score improved in the first 90 days in the cell therapy group compared with controls (P = 0.017, BMC group RC = -8%, controls RC = +5%). The model for end-stage liver disease score remained stable in the treated patients (RC -2 to +6%), whereas it increased during follow-up in the control group (RC +6 to +18%). Albumin levels improved in the treatment arm, whereas they remained stable among controls in the first 90 days (P = 0.034; BMC group RC = +16%, control group RC = +2%). Bilirubin levels increased among controls, whereas they decreased in the therapy arm during the first 60 days; INR RC differences between groups reached up to 10%. The changes observed did not persist beyond 90 days. Conclusion: Transplantation of autologous BMC into the hepatic artery improved liver function in patients with advanced cirrhosis in the first 90 days. However, larger studies are necessary to define the role of BMC therapy in cirrhotic patients. Repeated autologous BMC infusions or combination therapy with granulocyte-colony-stimulating factor might improve or sustain the treatment response.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-09-11T13:49:45Z No. of bitstreams: 1 00042737-201001000-00005.pdf: 262144 bytes, checksum: cd90401cc93bb9cd48cc317c3f9d7f97 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:42:53Z (GMT) No. of bitstreams: 1 00042737-201001000-00005.pdf: 262144 bytes, checksum: cd90401cc93bb9cd48cc317c3f9d7f97 (MD5)Made available in DSpace on 2013-10-31T17:42:53Z (GMT). No. of bitstreams: 1 00042737-201001000-00005.pdf: 262144 bytes, checksum: cd90401cc93bb9cd48cc317c3f9d7f97 (MD5) Previous issue date: 2010http://dx.doi.org/10.1097/MEG.0b013e32832eb69areponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABone marrow stem cell transplantationCD34Cell therapyChronic liver diseaseCirrhosisInfusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled studyEuropean Journal of Gastroenterology and Hepatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL00042737-201001000-00005.pdf00042737-201001000-00005.pdfapplication/pdf262144https://repositorio.ufba.br/bitstream/ri/13402/1/00042737-201001000-00005.pdfcd90401cc93bb9cd48cc317c3f9d7f97MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13402/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT00042737-201001000-00005.pdf.txt00042737-201001000-00005.pdf.txtExtracted texttext/plain41359https://repositorio.ufba.br/bitstream/ri/13402/3/00042737-201001000-00005.pdf.txt3ffdf473166ac82db0e175c107cc420dMD53ri/134022022-07-05 14:02:57.276oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:57Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study |
dc.title.alternative.pt_BR.fl_str_mv |
European Journal of Gastroenterology and Hepatology |
title |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study |
spellingShingle |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study Lyra, André Castro Bone marrow stem cell transplantation CD34 Cell therapy Chronic liver disease Cirrhosis |
title_short |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study |
title_full |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study |
title_fullStr |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study |
title_full_unstemmed |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study |
title_sort |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study |
author |
Lyra, André Castro |
author_facet |
Lyra, André Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla A. Fortes, Marcos Fraga Silva, Andre Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
author_role |
author |
author2 |
Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla A. Fortes, Marcos Fraga Silva, Andre Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lyra, André Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla A. Fortes, Marcos Fraga Silva, Andre Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa Lyra, André Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla A. Fortes, Marcos Fraga Silva, Andre Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
dc.subject.por.fl_str_mv |
Bone marrow stem cell transplantation CD34 Cell therapy Chronic liver disease Cirrhosis |
topic |
Bone marrow stem cell transplantation CD34 Cell therapy Chronic liver disease Cirrhosis |
description |
Texto completo: acesso restrito. p.33-42 |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2013-10-31T17:42:53Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://repositorio.ufba.br/ri/handle/ri/13402 |
dc.identifier.issn.none.fl_str_mv |
0954-691X |
dc.identifier.number.pt_BR.fl_str_mv |
v. 22, n. 1 |
identifier_str_mv |
0954-691X v. 22, n. 1 |
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http://repositorio.ufba.br/ri/handle/ri/13402 |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1097/MEG.0b013e32832eb69a |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Repositório Institucional da UFBA |
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