Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12447 |
Resumo: | Texto completo: acesso restrito. p.763–769 |
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Lima, Rosangela G.Moreira, LetíciaPaes Leme, JoanaSouza, Victor Barreto deFaria Neto, Hugo C. CastroBozza, Patrícia TorresBou-Habib, Dumith ChequerLima, Rosangela G.Moreira, LetíciaPaes Leme, JoanaSouza, Victor Barreto deFaria Neto, Hugo C. CastroBozza, Patrícia TorresBou-Habib, Dumith Chequer2013-08-05T12:51:30Z20060889-2229http://www.repositorio.ufba.br/ri/handle/ri/12447v.22 n. 8Texto completo: acesso restrito. p.763–769Phagocytosis of apoptotic cells by macrophages increases secretion of soluble mediators and generates an antiinflammatory environment. We previously reported that phagocytosis of apoptotic cells by HIV-1-infected macrophages enhances viral replication, with the participation of the cytokine transforming growth factor- β1 and an integrin receptor. Now, we describe the role of prostaglandin E2 (PGE2), platelet-activating factor (PAF), and the integrin α V β 3 (vitronectin receptor, VnR) in this phenomenon. Exacerbation of HIV-1 growth induced by phagocytosis of apoptotic cells was inhibited when HIV-1-infected macrophages were treated with a cyclooxygenase 2 inhibitor, or with a PAF receptor antagonist (BN 52021) immediately after macrophage interaction with apoptotic cells. Treatment of HIV-1-infected macrophages with BN 52021 decreased viral replication, whereas addition of PGE2 or PAF to these cells enhanced viral replication. Monoclonal antibodies (MAbs) to VnR reduced the macrophage uptake of apoptotic cells, prevented the enhancement of HIV-1 growth upon the engulfment of apoptotic cells, and potently augmented viral replication in HIV-1-infected macrophages in the absence of apoptotic cells. In conclusion, PGE2 and PAF, and ligation of VnR as well, contribute to amplify viral growth in HIV-1-infected macrophages upon uptake of apoptotic cells.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-01T18:17:08Z No. of bitstreams: 1 aid.2006.22.pdf: 165364 bytes, checksum: a6889fc0e5435daf769b58c07c4978a7 (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-05T12:51:30Z (GMT) No. of bitstreams: 1 aid.2006.22.pdf: 165364 bytes, checksum: a6889fc0e5435daf769b58c07c4978a7 (MD5)Made available in DSpace on 2013-08-05T12:51:30Z (GMT). No. of bitstreams: 1 aid.2006.22.pdf: 165364 bytes, checksum: a6889fc0e5435daf769b58c07c4978a7 (MD5) Previous issue date: 2006http://online.liebertpub.com.ez10.periodicos.capes.gov.br/doi/abs/10.1089/aid.2006.22.763reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMacrophagesAIDS SerodiagnosisVitronectinInteraction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin ReceptorAIDS Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALaid.2006.22.pdfaid.2006.22.pdfapplication/pdf165364https://repositorio.ufba.br/bitstream/ri/12447/1/aid.2006.22.pdfa6889fc0e5435daf769b58c07c4978a7MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12447/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTaid.2006.22.pdf.txtaid.2006.22.pdf.txtExtracted texttext/plain38862https://repositorio.ufba.br/bitstream/ri/12447/3/aid.2006.22.pdf.txtacf01d50c3669383907d6fccecd93514MD53ri/124472022-07-05 14:02:50.303oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor |
dc.title.alternative.pt_BR.fl_str_mv |
AIDS Research and Human Retroviruses |
title |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor |
spellingShingle |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor Lima, Rosangela G. Macrophages AIDS Serodiagnosis Vitronectin |
title_short |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor |
title_full |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor |
title_fullStr |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor |
title_full_unstemmed |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor |
title_sort |
Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor |
author |
Lima, Rosangela G. |
author_facet |
Lima, Rosangela G. Moreira, Letícia Paes Leme, Joana Souza, Victor Barreto de Faria Neto, Hugo C. Castro Bozza, Patrícia Torres Bou-Habib, Dumith Chequer |
author_role |
author |
author2 |
Moreira, Letícia Paes Leme, Joana Souza, Victor Barreto de Faria Neto, Hugo C. Castro Bozza, Patrícia Torres Bou-Habib, Dumith Chequer |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Rosangela G. Moreira, Letícia Paes Leme, Joana Souza, Victor Barreto de Faria Neto, Hugo C. Castro Bozza, Patrícia Torres Bou-Habib, Dumith Chequer Lima, Rosangela G. Moreira, Letícia Paes Leme, Joana Souza, Victor Barreto de Faria Neto, Hugo C. Castro Bozza, Patrícia Torres Bou-Habib, Dumith Chequer |
dc.subject.por.fl_str_mv |
Macrophages AIDS Serodiagnosis Vitronectin |
topic |
Macrophages AIDS Serodiagnosis Vitronectin |
description |
Texto completo: acesso restrito. p.763–769 |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2013-08-05T12:51:30Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/12447 |
dc.identifier.issn.none.fl_str_mv |
0889-2229 |
dc.identifier.number.pt_BR.fl_str_mv |
v.22 n. 8 |
identifier_str_mv |
0889-2229 v.22 n. 8 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/12447 |
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eng |
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eng |
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