Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation

Detalhes bibliográficos
Autor(a) principal: Galvão, Viviane
Data de Publicação: 2008
Outros Autores: Miranda, José Garcia Vivas, Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13890
Resumo: Texto completo: acesso restrito. p. 2051-2056
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spelling Galvão, VivianeMiranda, José Garcia VivasSantos, Ricardo Ribeiro dosGalvão, VivianeMiranda, José Garcia VivasSantos, Ricardo Ribeiro dos2013-11-26T12:57:07Z20081367-4803http://repositorio.ufba.br/ri/handle/ri/13890v. 24, n. 18Texto completo: acesso restrito. p. 2051-2056Motivation: A significant issue in stem cell therapy is to understand the role of this type of cell in the tissue regeneration. To explain this mechanism, an experimental study has quantified that the bone marrow cell transplantation decreases the number of inflammatory cells and reduces the fibrosis area in chagasic mice. Using this experimental data, we have developed an agent-based computational model to investigate the regeneration of the chronic chagasic cardiomyopathy after bone marrow stem cell transplantation. Results: Our model includes six different types of agents: inflammatory cell, fibrosis area, cardiomyocyte, proinflammatory cytokine tumor necrosis factor-α, Trypanosoma cruzi parasite and bone marrow stem cell. This latter promotes apoptosis in inflammatory cells, reduction in the fibrosis area and can differentiate into cardiomyocyte. Proinflammatory cytokine tumor necrosis factor-α can increase the fibrosis area and T.cruzi can increase the number of inflammatory cells. Our results for both apoptosis of inflammatory cells and reduction in the fibrosis area were compared with experimental data. They suggest that the concentration pattern is the most important factor to characterize the kinetics of cardiac tissue regeneration after bone marrow stem cell transplantation.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-26T11:48:23Z No. of bitstreams: 1 Bioinformatics-2008-Galvão-2051-6.pdf: 1422357 bytes, checksum: 04a5873b69bec93436f15b9b3f2054f5 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-26T12:57:06Z (GMT) No. of bitstreams: 1 Bioinformatics-2008-Galvão-2051-6.pdf: 1422357 bytes, checksum: 04a5873b69bec93436f15b9b3f2054f5 (MD5)Made available in DSpace on 2013-11-26T12:57:07Z (GMT). No. of bitstreams: 1 Bioinformatics-2008-Galvão-2051-6.pdf: 1422357 bytes, checksum: 04a5873b69bec93436f15b9b3f2054f5 (MD5) Previous issue date: 2008http://dx.doi.org/10.1093/bioinformatics/btn362reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBADevelopment of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantationBioinformaticsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALBioinformatics-2008-Galvão-2051-6.pdfBioinformatics-2008-Galvão-2051-6.pdfapplication/pdf1422357https://repositorio.ufba.br/bitstream/ri/13890/1/Bioinformatics-2008-Galv%c3%a3o-2051-6.pdf04a5873b69bec93436f15b9b3f2054f5MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13890/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTBioinformatics-2008-Galvão-2051-6.pdf.txtBioinformatics-2008-Galvão-2051-6.pdf.txtExtracted texttext/plain31482https://repositorio.ufba.br/bitstream/ri/13890/3/Bioinformatics-2008-Galv%c3%a3o-2051-6.pdf.txtdf1905e050b52dd9206dd2ec0d826132MD53ri/138902022-07-05 14:03:01.556oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
dc.title.alternative.pt_BR.fl_str_mv Bioinformatics
title Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
spellingShingle Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
Galvão, Viviane
title_short Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
title_full Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
title_fullStr Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
title_full_unstemmed Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
title_sort Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
author Galvão, Viviane
author_facet Galvão, Viviane
Miranda, José Garcia Vivas
Santos, Ricardo Ribeiro dos
author_role author
author2 Miranda, José Garcia Vivas
Santos, Ricardo Ribeiro dos
author2_role author
author
dc.contributor.author.fl_str_mv Galvão, Viviane
Miranda, José Garcia Vivas
Santos, Ricardo Ribeiro dos
Galvão, Viviane
Miranda, José Garcia Vivas
Santos, Ricardo Ribeiro dos
description Texto completo: acesso restrito. p. 2051-2056
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-11-26T12:57:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13890
dc.identifier.issn.none.fl_str_mv 1367-4803
dc.identifier.number.pt_BR.fl_str_mv v. 24, n. 18
identifier_str_mv 1367-4803
v. 24, n. 18
url http://repositorio.ufba.br/ri/handle/ri/13890
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1093/bioinformatics/btn362
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