Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats

Detalhes bibliográficos
Autor(a) principal: Castro e Silva, E. de
Data de Publicação: 2006
Outros Autores: Luz, P. A., Magrani, J., Andrade, L., Miranda, N., Pereira, V., Fregoneze, J. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12803
Resumo: Texto completo: acesso restrito.p.285–295
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spelling Castro e Silva, E. deLuz, P. A.Magrani, J.Andrade, L.Miranda, N.Pereira, V.Fregoneze, J. B.Castro e Silva, E. deLuz, P. A.Magrani, J.Andrade, L.Miranda, N.Pereira, V.Fregoneze, J. B.2013-09-02T19:00:20Z20060091-3057http://www.repositorio.ufba.br/ri/handle/ri/12803v.83 n. 2Texto completo: acesso restrito.p.285–295In the present study we investigated, the effect of third ventricle injections of IL-1β on water and salt intake in fluid-deprived and sodium-depleted rats. Central administration of IL-1β significantly reduced water and salt intake in fluid-deprived animals and decreased salt intake in sodium-depleted rats. The antidipsogenic and antinatriorexic effects elicited by the central administration of IL-1β were suppressed by pretreatment with central injections of the non-selective opioid antagonist naloxone (10 μg) in the two different experimental protocols used here (water deprivation and sodium depletion). In addition, central administration of IL-1β failed to modify the intake of a 0.1% saccharin solution when the animals were submitted to a “dessert test” or to induce any significant locomotor deficit in the open-field test. The present results suggest that the activation of the central interleukinergic component by IL-1β impairs the increase in water and salt intake induced by water deprivation and the enhancement in sodium appetite that follows sodium depletion. The data also support the conclusion that the antidipsogenic and antinatriorexic effects resulting from the activation of the central interleukinergic component rely on an opioid-dependent, naloxone-blockable system.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-02T16:37:02Z No. of bitstreams: 1 1-s2.0-S0091305706000347-main.pdf: 524016 bytes, checksum: e2f9e41fc62338949b76c2793eead6b8 (MD5)Approved for entry into archive by Patricia Barroso(pbarroso@ufba.br) on 2013-09-02T19:00:20Z (GMT) No. of bitstreams: 1 1-s2.0-S0091305706000347-main.pdf: 524016 bytes, checksum: e2f9e41fc62338949b76c2793eead6b8 (MD5)Made available in DSpace on 2013-09-02T19:00:20Z (GMT). No. of bitstreams: 1 1-s2.0-S0091305706000347-main.pdf: 524016 bytes, checksum: e2f9e41fc62338949b76c2793eead6b8 (MD5) Previous issue date: 2006http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.pbb.2006.02.009reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInterleukin-1βOpioidsWater intakeSalt intakeNaloxoneRole of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in ratsPharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0091305706000347-main.pdf1-s2.0-S0091305706000347-main.pdfapplication/pdf524016https://repositorio.ufba.br/bitstream/ri/12803/1/1-s2.0-S0091305706000347-main.pdfe2f9e41fc62338949b76c2793eead6b8MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12803/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0091305706000347-main.pdf.txt1-s2.0-S0091305706000347-main.pdf.txtExtracted texttext/plain55321https://repositorio.ufba.br/bitstream/ri/12803/3/1-s2.0-S0091305706000347-main.pdf.txt3f40531efbd001dde51e5db64474f194MD53ri/128032022-07-05 14:02:49.392oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
dc.title.alternative.pt_BR.fl_str_mv Pharmacology Biochemistry and Behavior
title Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
spellingShingle Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
Castro e Silva, E. de
Interleukin-1β
Opioids
Water intake
Salt intake
Naloxone
title_short Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
title_full Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
title_fullStr Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
title_full_unstemmed Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
title_sort Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1β in rats
author Castro e Silva, E. de
author_facet Castro e Silva, E. de
Luz, P. A.
Magrani, J.
Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J. B.
author_role author
author2 Luz, P. A.
Magrani, J.
Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J. B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro e Silva, E. de
Luz, P. A.
Magrani, J.
Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J. B.
Castro e Silva, E. de
Luz, P. A.
Magrani, J.
Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J. B.
dc.subject.por.fl_str_mv Interleukin-1β
Opioids
Water intake
Salt intake
Naloxone
topic Interleukin-1β
Opioids
Water intake
Salt intake
Naloxone
description Texto completo: acesso restrito.p.285–295
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-09-02T19:00:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12803
dc.identifier.issn.none.fl_str_mv 0091-3057
dc.identifier.number.pt_BR.fl_str_mv v.83 n. 2
identifier_str_mv 0091-3057
v.83 n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/12803
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.pbb.2006.02.009
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