Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system

Detalhes bibliográficos
Autor(a) principal: Luz, P. A.
Data de Publicação: 2006
Outros Autores: Andrade, L., Miranda, N., Pereira, V., Fregoneze, J., Silva, E. de Castro e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12762
Resumo: Texto completo: acesso restrito.p.85–94
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spelling Luz, P. A.Andrade, L.Miranda, N.Pereira, V.Fregoneze, J.Silva, E. de Castro eLuz, P. A.Andrade, L.Miranda, N.Pereira, V.Fregoneze, J.Silva, E. de Castro e2013-08-27T17:39:53Z20060143-4179http://www.repositorio.ufba.br/ri/handle/ri/12762v.40 n. 2Texto completo: acesso restrito.p.85–94In the present study we investigated, the effect of third ventricle injections of IL-1β on water intake, in rats, induced by three different physiological stimuli: dehydration induced by water deprivation, hypernatremia associated with hyperosmolarity induced by intragastric salt load, and hypovolemia produced by subcutaneous polytethyleneglycol administration. Central administration of IL-1β at the doses of 4 and 8 ng reduced water intake in all three conditions studied. Third ventricle injections of IL-1β (8 ng) were unable to diminish water intake in the groups of rats pretreated with central injections of the non-selective opioid antagonist naloxone (10 μg) in the three different conditions studied. Furthermore, the central administration of IL-1β was neither able to modify the intake of a 0.1% saccharin solution when the animals were submitted to a “dessert test” nor to induce any significant locomotor deficit in the open-field test. These results suggest that the central activation of interleukin-1 receptors by IL-1β is able to impair the thirst-inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia. These results lead us to conclude that the antidipsogenic effects observed following central administration of IL-1β require the functional integrity of the brain opiatergic system.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-27T14:25:55Z No. of bitstreams: 1 1-s2.0-S0143417905001290-main.pdf: 284108 bytes, checksum: 065feb6514472c768c8587340d48d014 (MD5)Approved for entry into archive by Patricia Barroso(pbarroso@ufba.br) on 2013-08-27T17:39:52Z (GMT) No. of bitstreams: 1 1-s2.0-S0143417905001290-main.pdf: 284108 bytes, checksum: 065feb6514472c768c8587340d48d014 (MD5)Made available in DSpace on 2013-08-27T17:39:53Z (GMT). No. of bitstreams: 1 1-s2.0-S0143417905001290-main.pdf: 284108 bytes, checksum: 065feb6514472c768c8587340d48d014 (MD5) Previous issue date: 2006http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.npep.2005.11.001reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOpioidsNaloxoneWater intakeHyperosmolarityHypovolemiaDehydrationInhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid systemNeuropeptidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0143417905001290-main.pdf1-s2.0-S0143417905001290-main.pdfapplication/pdf284108https://repositorio.ufba.br/bitstream/ri/12762/1/1-s2.0-S0143417905001290-main.pdf065feb6514472c768c8587340d48d014MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12762/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0143417905001290-main.pdf.txt1-s2.0-S0143417905001290-main.pdf.txtExtracted texttext/plain48955https://repositorio.ufba.br/bitstream/ri/12762/3/1-s2.0-S0143417905001290-main.pdf.txt9a29e3378f3b2f68a211a6999c08be49MD53ri/127622022-07-05 14:02:49.387oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
dc.title.alternative.pt_BR.fl_str_mv Neuropeptides
title Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
spellingShingle Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
Luz, P. A.
Opioids
Naloxone
Water intake
Hyperosmolarity
Hypovolemia
Dehydration
title_short Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
title_full Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
title_fullStr Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
title_full_unstemmed Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
title_sort Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system
author Luz, P. A.
author_facet Luz, P. A.
Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J.
Silva, E. de Castro e
author_role author
author2 Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J.
Silva, E. de Castro e
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Luz, P. A.
Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J.
Silva, E. de Castro e
Luz, P. A.
Andrade, L.
Miranda, N.
Pereira, V.
Fregoneze, J.
Silva, E. de Castro e
dc.subject.por.fl_str_mv Opioids
Naloxone
Water intake
Hyperosmolarity
Hypovolemia
Dehydration
topic Opioids
Naloxone
Water intake
Hyperosmolarity
Hypovolemia
Dehydration
description Texto completo: acesso restrito.p.85–94
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-08-27T17:39:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12762
dc.identifier.issn.none.fl_str_mv 0143-4179
dc.identifier.number.pt_BR.fl_str_mv v.40 n. 2
identifier_str_mv 0143-4179
v.40 n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/12762
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.npep.2005.11.001
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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institution UFBA
reponame_str Repositório Institucional da UFBA
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