Characterization of the immune response to Leishmania intum recombinant antigensfan
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/7374 |
Resumo: | Texto completo: acesso restrito. p. 7-12 |
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Carvalho, Lucas Pedreira deSoto, ManuelJerônimo, SelmaDondji, BlaiseBacellar, Maria Olívia Amado RamosLuz, VivianeOrge, Glória OrgeAlonso, CarlosJesus, Amélia R.Carvalho Filho, Edgar Marcelino deCarvalho, Lucas Pedreira deSoto, ManuelJerônimo, SelmaDondji, BlaiseBacellar, Maria Olívia Amado RamosLuz, VivianeOrge, Glória OrgeAlonso, CarlosJesus, Amélia R.Carvalho Filho, Edgar Marcelino de2012-12-10T17:00:35Z20031286-4579http://www.repositorio.ufba.br/ri/handle/ri/7374v. 5, n. 1Texto completo: acesso restrito. p. 7-12Leishmaniases have a high prevalence in tropical countries. In order to improve existing diagnostic systems based on total Leishmania proteins, and to identify antigen candidates for vaccine development, an intensive search for the identification of antigens was performed using molecular biology techniques. In this study, the immune response to three L. infantum recombinant antigens was evaluated. Upon stimulation with KMP11, mononuclear cells from leishmaniasis patients produced high levels of IL-10, while a predominant IFN-γ production could be observed in cultures stimulated with H2A and soluble Leishmania antigen. All the recombinant antigens induced very little IL-5. KMP11 decreased IFN-γ production by 48% in cultures of peripheral blood mononuclear cells from cutaneous leishmaniasis patients who had been stimulated with soluble Leishmania antigen. Furthermore, antibodies to KMP11 were detected in the sera from all patients with visceral leishmaniasis and in the majority of the sera from patients with cutaneous leishmaniasis or individuals with asymptomatic L. chagasi infection. Thus, KMP11 is recognized by cells and sera of patients with different clinical forms of leishmaniasis, and KMP11, through IL-10 production, proved to be a potent antigen in modulating type 1 immune response.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-10T17:00:35Z No. of bitstreams: 1 1-s2.0-S1286457902000515-main.pdf: 114743 bytes, checksum: dfbcf3fe3bbc3654b7c18cab2903f62d (MD5)Made available in DSpace on 2012-12-10T17:00:35Z (GMT). No. of bitstreams: 1 1-s2.0-S1286457902000515-main.pdf: 114743 bytes, checksum: dfbcf3fe3bbc3654b7c18cab2903f62d (MD5) Previous issue date: 2003http://dx.doi.org/10.1016/S1286-4579(02)00051-5reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisImmuneregulationIFN-γKMP11Characterization of the immune response to Leishmania intum recombinant antigensfanMicrobes and Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S1286457902000515-main.pdf1-s2.0-S1286457902000515-main.pdfapplication/pdf114743https://repositorio.ufba.br/bitstream/ri/7374/1/1-s2.0-S1286457902000515-main.pdfdfbcf3fe3bbc3654b7c18cab2903f62dMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7374/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S1286457902000515-main.pdf.txt1-s2.0-S1286457902000515-main.pdf.txtExtracted texttext/plain25668https://repositorio.ufba.br/bitstream/ri/7374/3/1-s2.0-S1286457902000515-main.pdf.txtd5c3582ddbe3a33fa0f116fcdd58a7eaMD53ri/73742022-07-05 14:03:23.27oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Characterization of the immune response to Leishmania intum recombinant antigensfan |
| dc.title.alternative.pt_BR.fl_str_mv |
Microbes and Infection |
| title |
Characterization of the immune response to Leishmania intum recombinant antigensfan |
| spellingShingle |
Characterization of the immune response to Leishmania intum recombinant antigensfan Carvalho, Lucas Pedreira de Leishmaniasis Immuneregulation IFN-γ KMP11 |
| title_short |
Characterization of the immune response to Leishmania intum recombinant antigensfan |
| title_full |
Characterization of the immune response to Leishmania intum recombinant antigensfan |
| title_fullStr |
Characterization of the immune response to Leishmania intum recombinant antigensfan |
| title_full_unstemmed |
Characterization of the immune response to Leishmania intum recombinant antigensfan |
| title_sort |
Characterization of the immune response to Leishmania intum recombinant antigensfan |
| author |
Carvalho, Lucas Pedreira de |
| author_facet |
Carvalho, Lucas Pedreira de Soto, Manuel Jerônimo, Selma Dondji, Blaise Bacellar, Maria Olívia Amado Ramos Luz, Viviane Orge, Glória Orge Alonso, Carlos Jesus, Amélia R. Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Soto, Manuel Jerônimo, Selma Dondji, Blaise Bacellar, Maria Olívia Amado Ramos Luz, Viviane Orge, Glória Orge Alonso, Carlos Jesus, Amélia R. Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Lucas Pedreira de Soto, Manuel Jerônimo, Selma Dondji, Blaise Bacellar, Maria Olívia Amado Ramos Luz, Viviane Orge, Glória Orge Alonso, Carlos Jesus, Amélia R. Carvalho Filho, Edgar Marcelino de Carvalho, Lucas Pedreira de Soto, Manuel Jerônimo, Selma Dondji, Blaise Bacellar, Maria Olívia Amado Ramos Luz, Viviane Orge, Glória Orge Alonso, Carlos Jesus, Amélia R. Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Leishmaniasis Immuneregulation IFN-γ KMP11 |
| topic |
Leishmaniasis Immuneregulation IFN-γ KMP11 |
| description |
Texto completo: acesso restrito. p. 7-12 |
| publishDate |
2003 |
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2003 |
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2012-12-10T17:00:35Z |
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1286-4579 |
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v. 5, n. 1 |
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1286-4579 v. 5, n. 1 |
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