Characterization of the immune response to Leishmania intum recombinant antigensfan

Detalhes bibliográficos
Autor(a) principal: Carvalho, Lucas Pedreira de
Data de Publicação: 2003
Outros Autores: Soto, Manuel, Jerônimo, Selma, Dondji, Blaise, Bacellar, Maria Olívia Amado Ramos, Luz, Viviane, Orge, Glória Orge, Alonso, Carlos, Jesus, Amélia R., Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7374
Resumo: Texto completo: acesso restrito. p. 7-12
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spelling Carvalho, Lucas Pedreira deSoto, ManuelJerônimo, SelmaDondji, BlaiseBacellar, Maria Olívia Amado RamosLuz, VivianeOrge, Glória OrgeAlonso, CarlosJesus, Amélia R.Carvalho Filho, Edgar Marcelino deCarvalho, Lucas Pedreira deSoto, ManuelJerônimo, SelmaDondji, BlaiseBacellar, Maria Olívia Amado RamosLuz, VivianeOrge, Glória OrgeAlonso, CarlosJesus, Amélia R.Carvalho Filho, Edgar Marcelino de2012-12-10T17:00:35Z20031286-4579http://www.repositorio.ufba.br/ri/handle/ri/7374v. 5, n. 1Texto completo: acesso restrito. p. 7-12Leishmaniases have a high prevalence in tropical countries. In order to improve existing diagnostic systems based on total Leishmania proteins, and to identify antigen candidates for vaccine development, an intensive search for the identification of antigens was performed using molecular biology techniques. In this study, the immune response to three L. infantum recombinant antigens was evaluated. Upon stimulation with KMP11, mononuclear cells from leishmaniasis patients produced high levels of IL-10, while a predominant IFN-γ production could be observed in cultures stimulated with H2A and soluble Leishmania antigen. All the recombinant antigens induced very little IL-5. KMP11 decreased IFN-γ production by 48% in cultures of peripheral blood mononuclear cells from cutaneous leishmaniasis patients who had been stimulated with soluble Leishmania antigen. Furthermore, antibodies to KMP11 were detected in the sera from all patients with visceral leishmaniasis and in the majority of the sera from patients with cutaneous leishmaniasis or individuals with asymptomatic L. chagasi infection. Thus, KMP11 is recognized by cells and sera of patients with different clinical forms of leishmaniasis, and KMP11, through IL-10 production, proved to be a potent antigen in modulating type 1 immune response.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-10T17:00:35Z No. of bitstreams: 1 1-s2.0-S1286457902000515-main.pdf: 114743 bytes, checksum: dfbcf3fe3bbc3654b7c18cab2903f62d (MD5)Made available in DSpace on 2012-12-10T17:00:35Z (GMT). No. of bitstreams: 1 1-s2.0-S1286457902000515-main.pdf: 114743 bytes, checksum: dfbcf3fe3bbc3654b7c18cab2903f62d (MD5) Previous issue date: 2003http://dx.doi.org/10.1016/S1286-4579(02)00051-5reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisImmuneregulationIFN-γKMP11Characterization of the immune response to Leishmania intum recombinant antigensfanMicrobes and Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S1286457902000515-main.pdf1-s2.0-S1286457902000515-main.pdfapplication/pdf114743https://repositorio.ufba.br/bitstream/ri/7374/1/1-s2.0-S1286457902000515-main.pdfdfbcf3fe3bbc3654b7c18cab2903f62dMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7374/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S1286457902000515-main.pdf.txt1-s2.0-S1286457902000515-main.pdf.txtExtracted texttext/plain25668https://repositorio.ufba.br/bitstream/ri/7374/3/1-s2.0-S1286457902000515-main.pdf.txtd5c3582ddbe3a33fa0f116fcdd58a7eaMD53ri/73742022-07-05 14:03:23.27oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Characterization of the immune response to Leishmania intum recombinant antigensfan
dc.title.alternative.pt_BR.fl_str_mv Microbes and Infection
title Characterization of the immune response to Leishmania intum recombinant antigensfan
spellingShingle Characterization of the immune response to Leishmania intum recombinant antigensfan
Carvalho, Lucas Pedreira de
Leishmaniasis
Immuneregulation
IFN-γ
KMP11
title_short Characterization of the immune response to Leishmania intum recombinant antigensfan
title_full Characterization of the immune response to Leishmania intum recombinant antigensfan
title_fullStr Characterization of the immune response to Leishmania intum recombinant antigensfan
title_full_unstemmed Characterization of the immune response to Leishmania intum recombinant antigensfan
title_sort Characterization of the immune response to Leishmania intum recombinant antigensfan
author Carvalho, Lucas Pedreira de
author_facet Carvalho, Lucas Pedreira de
Soto, Manuel
Jerônimo, Selma
Dondji, Blaise
Bacellar, Maria Olívia Amado Ramos
Luz, Viviane
Orge, Glória Orge
Alonso, Carlos
Jesus, Amélia R.
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Soto, Manuel
Jerônimo, Selma
Dondji, Blaise
Bacellar, Maria Olívia Amado Ramos
Luz, Viviane
Orge, Glória Orge
Alonso, Carlos
Jesus, Amélia R.
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Lucas Pedreira de
Soto, Manuel
Jerônimo, Selma
Dondji, Blaise
Bacellar, Maria Olívia Amado Ramos
Luz, Viviane
Orge, Glória Orge
Alonso, Carlos
Jesus, Amélia R.
Carvalho Filho, Edgar Marcelino de
Carvalho, Lucas Pedreira de
Soto, Manuel
Jerônimo, Selma
Dondji, Blaise
Bacellar, Maria Olívia Amado Ramos
Luz, Viviane
Orge, Glória Orge
Alonso, Carlos
Jesus, Amélia R.
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Leishmaniasis
Immuneregulation
IFN-γ
KMP11
topic Leishmaniasis
Immuneregulation
IFN-γ
KMP11
description Texto completo: acesso restrito. p. 7-12
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2012-12-10T17:00:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7374
dc.identifier.issn.none.fl_str_mv 1286-4579
dc.identifier.number.pt_BR.fl_str_mv v. 5, n. 1
identifier_str_mv 1286-4579
v. 5, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7374
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S1286-4579(02)00051-5
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