Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14208 |
Resumo: | Texto completo: acesso restrito. p. 58-64 |
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Pereira, Fernanda AlbuquerqueSilva, Naize Nara Pinheiro daRodart, Itatiana FerreiraCarmo, Theomira Mauadie AzevedoLemaire, Denise CarneiroReis, Mitermayer GalvãoPereira, Fernanda AlbuquerqueSilva, Naize Nara Pinheiro daRodart, Itatiana FerreiraCarmo, Theomira Mauadie AzevedoLemaire, Denise CarneiroReis, Mitermayer Galvão2013-12-17T16:02:12Z20080146-6615http://repositorio.ufba.br/ri/handle/ri/14208v. 80, n. 1Texto completo: acesso restrito. p. 58-64Cytokines play a key role in the regulation of immune responses. In hepatitis C virus infection (HCV), the production of abnormal cytokine levels appears to contribute to the progression of the disease, viral persistence, and affects response to therapy. Cytokine genes are polymorphic at specific sites, and certain polymorphisms located within coding/regulatory regions have been shown to affect the overall expression and secretion of cytokines. The aim of the present study was to identify potential markers of cytokines genes associated with the susceptibility to HCV infection. The cohort was composed of 128 individuals infected by HCV and 94 healthy controls. Genotyping was carried out by PCR-SSP. The distributions of the following polymorphisms were compared in these groups: TNF-α (−308G/A [rs1800629]), TGF-β1 (codon 10 T/C [rs1982073], codon 25 G/C [rs1800471]), IL-10 (−1082 A/G [rs 1800896]; −819T/C [rs1800871]; −592A/C [rs 1800872]), IL-6 (−174G/C [rs1800795]), and IFN-γ (+874T/A [rs2430561]). This study demonstrated a statistically significant difference in the frequency of TGF-β1 codon 25 polymorphism between healthy subjects and those infected with HCV. No associations were observed between polymorphisms of TNF-α, IFN-γ, IL-10, TGF-β1 codon 10, and IL-6 and HCV infection. These findings suggest that TGF-β1 codon 25 polymorphism could be a host genetic factor associated with susceptibility to HCV infection.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-17T10:37:23Z No. of bitstreams: 1 10.1002jmv.21011.pdf: 118428 bytes, checksum: b99cd45762246fcf378e3ff767691dfa (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2013-12-17T16:02:11Z (GMT) No. of bitstreams: 1 10.1002jmv.21011.pdf: 118428 bytes, checksum: b99cd45762246fcf378e3ff767691dfa (MD5)Made available in DSpace on 2013-12-17T16:02:12Z (GMT). No. of bitstreams: 1 10.1002jmv.21011.pdf: 118428 bytes, checksum: b99cd45762246fcf378e3ff767691dfa (MD5) Previous issue date: 2008http://dx.doi.org/10.1002/jmv.21011reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHepatitis CGenesCytokinesPolymorphism (genetics)Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infectionJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1002jmv.21011.pdf10.1002jmv.21011.pdfapplication/pdf118428https://repositorio.ufba.br/bitstream/ri/14208/1/10.1002jmv.21011.pdfb99cd45762246fcf378e3ff767691dfaMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14208/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1002jmv.21011.pdf.txt10.1002jmv.21011.pdf.txtExtracted texttext/plain37233https://repositorio.ufba.br/bitstream/ri/14208/3/10.1002jmv.21011.pdf.txtc125d3d46b979c536cf44fb7ace76e5fMD53ri/142082022-08-08 13:19:52.17oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:19:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Medical Virology |
| title |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection |
| spellingShingle |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection Pereira, Fernanda Albuquerque Hepatitis C Genes Cytokines Polymorphism (genetics) |
| title_short |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection |
| title_full |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection |
| title_fullStr |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection |
| title_full_unstemmed |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection |
| title_sort |
Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection |
| author |
Pereira, Fernanda Albuquerque |
| author_facet |
Pereira, Fernanda Albuquerque Silva, Naize Nara Pinheiro da Rodart, Itatiana Ferreira Carmo, Theomira Mauadie Azevedo Lemaire, Denise Carneiro Reis, Mitermayer Galvão |
| author_role |
author |
| author2 |
Silva, Naize Nara Pinheiro da Rodart, Itatiana Ferreira Carmo, Theomira Mauadie Azevedo Lemaire, Denise Carneiro Reis, Mitermayer Galvão |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira, Fernanda Albuquerque Silva, Naize Nara Pinheiro da Rodart, Itatiana Ferreira Carmo, Theomira Mauadie Azevedo Lemaire, Denise Carneiro Reis, Mitermayer Galvão Pereira, Fernanda Albuquerque Silva, Naize Nara Pinheiro da Rodart, Itatiana Ferreira Carmo, Theomira Mauadie Azevedo Lemaire, Denise Carneiro Reis, Mitermayer Galvão |
| dc.subject.por.fl_str_mv |
Hepatitis C Genes Cytokines Polymorphism (genetics) |
| topic |
Hepatitis C Genes Cytokines Polymorphism (genetics) |
| description |
Texto completo: acesso restrito. p. 58-64 |
| publishDate |
2008 |
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2008 |
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2013-12-17T16:02:12Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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0146-6615 |
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v. 80, n. 1 |
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0146-6615 v. 80, n. 1 |
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