Central administration of zinc increases renal sodium and potassium excretion in rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/7970 |
Resumo: | Texto completo: acesso restrito. p.176–184 |
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1932 |
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Silva, Emilio de Castro eLuz, Carla P.Marinho, Carol A.Castro, LetíciaSarmento, ClarissaGonzalez, VirnaOliveira, PatríciaNascimento, ThaisSantana Jr, PedroLima, Ana K.Fregoneze, Josmara B.Silva, Emilio de Castro eLuz, Carla P.Marinho, Carol A.Castro, LetíciaSarmento, ClarissaGonzalez, VirnaOliveira, PatríciaNascimento, ThaisSantana Jr, PedroLima, Ana K.Fregoneze, Josmara B.2013-01-18T11:08:37Z19990006-8993http://www.repositorio.ufba.br/ri/handle/ri/7970v. 845, n. 2Texto completo: acesso restrito. p.176–184The aim of the present study was to investigate the effect of acute third ventricle injections of zinc on the brain control of renal sodium and potassium excretion. Adult Wistar male rats received third ventricle injections of zinc acetate in three different doses (0.03, 0.3 and 3.0 nmol/rat). Third ventricle administration of zinc acetate provoked a significant intensification of natriuresis and kaliuresis as compared to sodium acetate-treated controls. When rats were pretreated with losartan, a selective angiotensin II AT1 receptor antagonist (10.8 nmol/rat into the third ventricle 10 min before central zinc injection) the increase in both natriuresis and kaliuresis was abolished. Furthermore, pretreatment with gadolinium, a calcium channel blocker (0.3 nmol/rat into the third ventricle 20 min before central zinc injection), also blunted the increase in renal sodium and potassium excretion seen in animals receiving zinc alone. In a group of rats receiving the same water load used in the previous experiments, the injection of zinc acetate into the third ventricle (3.0 nmol/rat) did not modify arterial blood pressure. It is suggested that zinc in the central nervous system may be involved in the control of renal sodium and potassium excretion by a mechanism unrelated to blood pressure increase. It is also shown that both natriuretic and kaliuretic actions of zinc depend on AT1 receptor activation. Whatever should be the mechanism(s) related to the central effects of zinc here evidenced, the functional integrity of calcium channels is required.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-18T11:08:37Z No. of bitstreams: 1 Silva.pdf: 257229 bytes, checksum: 726a11e8b6867f6f8665f2016da6652a (MD5)Made available in DSpace on 2013-01-18T11:08:37Z (GMT). No. of bitstreams: 1 Silva.pdf: 257229 bytes, checksum: 726a11e8b6867f6f8665f2016da6652a (MD5) Previous issue date: 1999http://dx.doi.org/10.1016/S0006-8993(99)01930-7reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAngiotensin IICalcium channelRenal functionGadoliniumLosartanZincBlood pressureCentral administration of zinc increases renal sodium and potassium excretion in ratsBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALSilva.pdfSilva.pdfapplication/pdf257229https://repositorio.ufba.br/bitstream/ri/7970/1/Silva.pdf726a11e8b6867f6f8665f2016da6652aMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7970/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTSilva.pdf.txtSilva.pdf.txtExtracted texttext/plain45304https://repositorio.ufba.br/bitstream/ri/7970/3/Silva.pdf.txtc342270b50ef560bf84774e8dc51108dMD53ri/79702022-07-05 14:03:03.549oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Central administration of zinc increases renal sodium and potassium excretion in rats |
| dc.title.alternative.pt_BR.fl_str_mv |
Brain Research |
| title |
Central administration of zinc increases renal sodium and potassium excretion in rats |
| spellingShingle |
Central administration of zinc increases renal sodium and potassium excretion in rats Silva, Emilio de Castro e Angiotensin II Calcium channel Renal function Gadolinium Losartan Zinc Blood pressure |
| title_short |
Central administration of zinc increases renal sodium and potassium excretion in rats |
| title_full |
Central administration of zinc increases renal sodium and potassium excretion in rats |
| title_fullStr |
Central administration of zinc increases renal sodium and potassium excretion in rats |
| title_full_unstemmed |
Central administration of zinc increases renal sodium and potassium excretion in rats |
| title_sort |
Central administration of zinc increases renal sodium and potassium excretion in rats |
| author |
Silva, Emilio de Castro e |
| author_facet |
Silva, Emilio de Castro e Luz, Carla P. Marinho, Carol A. Castro, Letícia Sarmento, Clarissa Gonzalez, Virna Oliveira, Patrícia Nascimento, Thais Santana Jr, Pedro Lima, Ana K. Fregoneze, Josmara B. |
| author_role |
author |
| author2 |
Luz, Carla P. Marinho, Carol A. Castro, Letícia Sarmento, Clarissa Gonzalez, Virna Oliveira, Patrícia Nascimento, Thais Santana Jr, Pedro Lima, Ana K. Fregoneze, Josmara B. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Emilio de Castro e Luz, Carla P. Marinho, Carol A. Castro, Letícia Sarmento, Clarissa Gonzalez, Virna Oliveira, Patrícia Nascimento, Thais Santana Jr, Pedro Lima, Ana K. Fregoneze, Josmara B. Silva, Emilio de Castro e Luz, Carla P. Marinho, Carol A. Castro, Letícia Sarmento, Clarissa Gonzalez, Virna Oliveira, Patrícia Nascimento, Thais Santana Jr, Pedro Lima, Ana K. Fregoneze, Josmara B. |
| dc.subject.por.fl_str_mv |
Angiotensin II Calcium channel Renal function Gadolinium Losartan Zinc Blood pressure |
| topic |
Angiotensin II Calcium channel Renal function Gadolinium Losartan Zinc Blood pressure |
| description |
Texto completo: acesso restrito. p.176–184 |
| publishDate |
1999 |
| dc.date.issued.fl_str_mv |
1999 |
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2013-01-18T11:08:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://www.repositorio.ufba.br/ri/handle/ri/7970 |
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0006-8993 |
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v. 845, n. 2 |
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0006-8993 v. 845, n. 2 |
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http://www.repositorio.ufba.br/ri/handle/ri/7970 |
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