Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Oliveira, Lidia S. de
Data de Publicação: 2008
Outros Autores: Rodrigues, Frederico de M., Oliveira, Fábio Santos de, Mesquita, Paulo Roberto Ribeiro de, Leal, Danielle C., Alcântara, Adriano Costa de, Souza, Bárbara Maria Paraná da Silva, Franke, Carlos R., Pereira, Pedro Afonso de Paula, Andrade, Jailson Bittencourt de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5998
Resumo: Acesso restrito: Texto completo. p. 392-398
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spelling Oliveira, Lidia S. deRodrigues, Frederico de M.Oliveira, Fábio Santos deMesquita, Paulo Roberto Ribeiro deLeal, Danielle C.Alcântara, Adriano Costa deSouza, Bárbara Maria Paraná da SilvaFranke, Carlos R.Pereira, Pedro Afonso de PaulaAndrade, Jailson Bittencourt deOliveira, Lidia S. deRodrigues, Frederico de M.Oliveira, Fábio Santos deMesquita, Paulo Roberto Ribeiro deLeal, Danielle C.Alcântara, Adriano Costa deSouza, Bárbara Maria Paraná da SilvaFranke, Carlos R.Pereira, Pedro Afonso de PaulaAndrade, Jailson Bittencourt de2012-05-30T18:21:45Z20081570-0232http://www.repositorio.ufba.br/ri/handle/ri/5998v. 875, n. 2Acesso restrito: Texto completo. p. 392-398A new analytical methodology using HS-SPME/GC–MS was optimized in order to attain maximum sensitivity, using multivariate strategies. The proposed method was employed to evaluate the VOC profile exhaled fromcanine hair samples collected from 8 healthy dogs and from 16 dogs infected by Leishmania infantum. 274 VOCs were detected, which could be identified as aldehydes, ketones and hydrocarbons. After application of the Soft Independent Modeling of Class Analogy (SIMCA) and Principal Component Analysis (PCA) healthy and infected dogs, with similar VOCs profiles, could be separately grouped, based on compounds such as 2-hexanone, benzaldehyde, and 2,4-nonadienal. The proposed method is noninvasive, painless, readily accepted by dog owners and could be useful to identify several biomarkers with applications in the diagnosis of diseases.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-30T18:21:45Z No. of bitstreams: 1 __ac.els-cdn.com_S157002...93b0c561dc63c3cd50f005ac78284.pdf: 444342 bytes, checksum: 8fc8e0c31b4fab1eef3fa060276704b6 (MD5)Made available in DSpace on 2012-05-30T18:21:45Z (GMT). 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dc.title.pt_BR.fl_str_mv Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
title Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
spellingShingle Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
Oliveira, Lidia S. de
Canine hair
VOCs
HS-SPME/GC–MS
Multivariate optimization
PCA
Diagnosis
Visceral leishmaniasis
title_short Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
title_full Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
title_fullStr Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
title_full_unstemmed Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
title_sort Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
author Oliveira, Lidia S. de
author_facet Oliveira, Lidia S. de
Rodrigues, Frederico de M.
Oliveira, Fábio Santos de
Mesquita, Paulo Roberto Ribeiro de
Leal, Danielle C.
Alcântara, Adriano Costa de
Souza, Bárbara Maria Paraná da Silva
Franke, Carlos R.
Pereira, Pedro Afonso de Paula
Andrade, Jailson Bittencourt de
author_role author
author2 Rodrigues, Frederico de M.
Oliveira, Fábio Santos de
Mesquita, Paulo Roberto Ribeiro de
Leal, Danielle C.
Alcântara, Adriano Costa de
Souza, Bárbara Maria Paraná da Silva
Franke, Carlos R.
Pereira, Pedro Afonso de Paula
Andrade, Jailson Bittencourt de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Lidia S. de
Rodrigues, Frederico de M.
Oliveira, Fábio Santos de
Mesquita, Paulo Roberto Ribeiro de
Leal, Danielle C.
Alcântara, Adriano Costa de
Souza, Bárbara Maria Paraná da Silva
Franke, Carlos R.
Pereira, Pedro Afonso de Paula
Andrade, Jailson Bittencourt de
Oliveira, Lidia S. de
Rodrigues, Frederico de M.
Oliveira, Fábio Santos de
Mesquita, Paulo Roberto Ribeiro de
Leal, Danielle C.
Alcântara, Adriano Costa de
Souza, Bárbara Maria Paraná da Silva
Franke, Carlos R.
Pereira, Pedro Afonso de Paula
Andrade, Jailson Bittencourt de
dc.subject.por.fl_str_mv Canine hair
VOCs
HS-SPME/GC–MS
Multivariate optimization
PCA
Diagnosis
Visceral leishmaniasis
topic Canine hair
VOCs
HS-SPME/GC–MS
Multivariate optimization
PCA
Diagnosis
Visceral leishmaniasis
description Acesso restrito: Texto completo. p. 392-398
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-05-30T18:21:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5998
dc.identifier.issn.none.fl_str_mv 1570-0232
dc.identifier.number.pt_BR.fl_str_mv v. 875, n. 2
identifier_str_mv 1570-0232
v. 875, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/5998
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.jchromb.2008.09.028
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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