Phenotype analysis of lymphocytes of workers with chronic benzene poisoning
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5229 |
Resumo: | p. 65–70 |
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Brandão, Márcia Maria dos AnjosRêgo, Marco Antônio VasconcelosPugliese, Lívia SouzaAndrade, Jorge Clarencio SouzaNascimento, Roberto José MeyerFreire, Songeli MenezesBastos, Clara MaiaNeves, MarciaFerreira, J.Brandão, Márcia Maria dos AnjosRêgo, Marco Antônio VasconcelosPugliese, Lívia SouzaAndrade, Jorge Clarencio SouzaNascimento, Roberto José MeyerFreire, Songeli MenezesBastos, Clara MaiaNeves, MarciaFerreira, J.2012-01-23T17:27:54Z2012-01-23T17:27:54Z20050165-2478http://www.repositorio.ufba.br/ri/handle/ri/5229v. 101p. 65–70Lifetime exposure to benzene is associated to a variety of blood disorders, and except for the risk of cancer, almost nothing is known concerning health impairment in individuals who are no longer exposed. In Brazil, this exposure is one of the serious problems in workplaces, and many workers have been laid off their jobs due to this intoxication, particularly in the State of Bahia, the largest producer of benzene in Latin America, which is the area of this study. From a larger study to describe health effects and genetic polymorphisms among workers with chronic benzene poisoning (CBP), this previous specific investigation analyzes the association between CBP and the pattern of sub-populations of lymphocytes. The study was performed with a CBP group (n = 24) and a control group with other occupational diseases (n = 24); both were selected at the Workers Health Study Center in the State of Bahia, Brazil. Clinical and epidemiologic variables were collected from medical records and from a detailed questionnaire. The average age was similar in the two groups (51.1 and 50.7, respectively). Analyzing the mean proportions of the sub-populations of lymphocytes, statistically significant differences were found for T cytotoxic cells (TCD8) (27.9; 19.4; p = 0.002) and T helper memory cell (CD4CD45RO) (31.2; 37.0; p = 0.015), respectively, for the CBP group and control group. These results should be viewed with caution because of the small sample size, but they strengthen a previous impression that workers exposed to benzene have their immune system impaired, even in the long term, which may contribute to some disorders and carcinogenesis process. These workers must be strictly followed up in a medical surveillance program. Although this problem has been known for a long time, this is the first attempt to study these specific effects in Brazil.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-23T17:27:54Z No. of bitstreams: 1 S016524780500101X-main.pdf: 86198 bytes, checksum: edc152f905e954d5c1f1cfbd6399ac86 (MD5)Made available in DSpace on 2012-01-23T17:27:54Z (GMT). No. of bitstreams: 1 S016524780500101X-main.pdf: 86198 bytes, checksum: edc152f905e954d5c1f1cfbd6399ac86 (MD5) Previous issue date: 2005Flow cytometryLymphocyte phenotypeCD antigensOccupational exposureBenzeneImmunotoxicityPhenotype analysis of lymphocytes of workers with chronic benzene poisoningImmunology Lettersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALS016524780500101X-main.pdfS016524780500101X-main.pdfapplication/pdf86198https://repositorio.ufba.br/bitstream/ri/5229/1/S016524780500101X-main.pdfedc152f905e954d5c1f1cfbd6399ac86MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5229/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTS016524780500101X-main.pdf.txtS016524780500101X-main.pdf.txtExtracted texttext/plain30858https://repositorio.ufba.br/bitstream/ri/5229/3/S016524780500101X-main.pdf.txt6b07a04e934d63d9e74f1b7842463287MD53ri/52292022-07-05 14:03:13.13oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning |
| dc.title.alternative.pt_BR.fl_str_mv |
Immunology Letters |
| title |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning |
| spellingShingle |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning Brandão, Márcia Maria dos Anjos Flow cytometry Lymphocyte phenotype CD antigens Occupational exposure Benzene Immunotoxicity |
| title_short |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning |
| title_full |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning |
| title_fullStr |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning |
| title_full_unstemmed |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning |
| title_sort |
Phenotype analysis of lymphocytes of workers with chronic benzene poisoning |
| author |
Brandão, Márcia Maria dos Anjos |
| author_facet |
Brandão, Márcia Maria dos Anjos Rêgo, Marco Antônio Vasconcelos Pugliese, Lívia Souza Andrade, Jorge Clarencio Souza Nascimento, Roberto José Meyer Freire, Songeli Menezes Bastos, Clara Maia Neves, Marcia Ferreira, J. |
| author_role |
author |
| author2 |
Rêgo, Marco Antônio Vasconcelos Pugliese, Lívia Souza Andrade, Jorge Clarencio Souza Nascimento, Roberto José Meyer Freire, Songeli Menezes Bastos, Clara Maia Neves, Marcia Ferreira, J. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Brandão, Márcia Maria dos Anjos Rêgo, Marco Antônio Vasconcelos Pugliese, Lívia Souza Andrade, Jorge Clarencio Souza Nascimento, Roberto José Meyer Freire, Songeli Menezes Bastos, Clara Maia Neves, Marcia Ferreira, J. Brandão, Márcia Maria dos Anjos Rêgo, Marco Antônio Vasconcelos Pugliese, Lívia Souza Andrade, Jorge Clarencio Souza Nascimento, Roberto José Meyer Freire, Songeli Menezes Bastos, Clara Maia Neves, Marcia Ferreira, J. |
| dc.subject.por.fl_str_mv |
Flow cytometry Lymphocyte phenotype CD antigens Occupational exposure Benzene Immunotoxicity |
| topic |
Flow cytometry Lymphocyte phenotype CD antigens Occupational exposure Benzene Immunotoxicity |
| description |
p. 65–70 |
| publishDate |
2005 |
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2005 |
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2012-01-23T17:27:54Z |
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2012-01-23T17:27:54Z |
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0165-2478 |
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v. 101 |
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0165-2478 v. 101 |
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