Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size

Detalhes bibliográficos
Autor(a) principal: Vieira, É. L. M.
Data de Publicação: 2013
Outros Autores: Keesen, T. S. L., Machado, Paulo Roberto Lima, Guimarães, L. H., Carvalho Filho, Edgar Marcelino de, Dutra, Walderez Ornelas, Gollob, K. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/17127
Resumo: Texto completo: acesso restrito. p. 65–72
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spelling Vieira, É. L. M.Keesen, T. S. L.Machado, Paulo Roberto LimaGuimarães, L. H.Carvalho Filho, Edgar Marcelino deDutra, Walderez OrnelasGollob, K. J.Vieira, É. L. M.Keesen, T. S. L.Machado, Paulo Roberto LimaGuimarães, L. H.Carvalho Filho, Edgar Marcelino deDutra, Walderez OrnelasGollob, K. J.2015-03-10T19:23:31Z20130141-9838http://repositorio.ufba.br/ri/handle/ri/17127v. 35, n. 2Texto completo: acesso restrito. p. 65–72Leishmaniasis is an important tropical disease composed of several clinical forms that adversely affect millions of people globally. Critical cells involved in the host–Leishmania interaction are monocytes and macrophages, which act to protect against infections due to their ability to both control intracellular infections and regulate the subsequent adaptive immune response. Both soluble factors and cell surface receptors are keys in directing the immune response following interaction with pathogens such as Leishmania. Toll-like receptors (TLRs) have an essential role in immune responses against infections, but little is known about their role in human infection with Leishmania braziliensis. In this work, we evaluated peripheral blood CD14+ monocytes for the expression of immunoregulatory cytokines, co-stimulatory molecules and TLR9 from cutaneous leishmaniasis patients infected with L. braziliensis and noninfected individuals. Our results showed that patients present decreased expression of co-stimulatory molecules such as CD80 and CD86 following culture with media alone or after stimulus with soluble Leishmania antigen. Interestingly, TLR9 expression was higher after culture with soluble Leishmania antigen (SLA), suggesting a role of this molecule in immunoregulation of active disease. Lastly, higher frequencies of TLR9+ monocytes were correlated with greater lesion size. These findings demonstrate a peripheral monocytes profile compatible with important immunoregulatory potential.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2015-03-09T12:10:51Z No. of bitstreams: 1 É. L. M. Vieira.pdf: 619772 bytes, checksum: b04d562c03f21386536a6a0d26c41f82 (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2015-03-10T19:23:31Z (GMT) No. of bitstreams: 1 É. L. M. Vieira.pdf: 619772 bytes, checksum: b04d562c03f21386536a6a0d26c41f82 (MD5)Made available in DSpace on 2015-03-10T19:23:31Z (GMT). No. of bitstreams: 1 É. L. M. Vieira.pdf: 619772 bytes, checksum: b04d562c03f21386536a6a0d26c41f82 (MD5) Previous issue date: 2013http://dx.doi.org/10.1111/pim.12012http://dx.doi.org/10.1111/pim.12012reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACo-stimulatory moleculesCutaneous leishmaniasisCytokinesHumanImmunoregulationLeishmaniaMonocytesTLR9Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion sizeParasite Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALÉ. L. M. Vieira.pdfÉ. L. M. Vieira.pdfapplication/pdf619772https://repositorio.ufba.br/bitstream/ri/17127/1/%c3%89.%20L.%20M.%20Vieira.pdfb04d562c03f21386536a6a0d26c41f82MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17127/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTÉ. L. M. Vieira.pdf.txtÉ. L. M. 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dc.title.pt_BR.fl_str_mv Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
dc.title.alternative.pt_BR.fl_str_mv Parasite Immunology
title Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
spellingShingle Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
Vieira, É. L. M.
Co-stimulatory molecules
Cutaneous leishmaniasis
Cytokines
Human
Immunoregulation
Leishmania
Monocytes
TLR9
title_short Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
title_full Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
title_fullStr Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
title_full_unstemmed Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
title_sort Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size
author Vieira, É. L. M.
author_facet Vieira, É. L. M.
Keesen, T. S. L.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Carvalho Filho, Edgar Marcelino de
Dutra, Walderez Ornelas
Gollob, K. J.
author_role author
author2 Keesen, T. S. L.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Carvalho Filho, Edgar Marcelino de
Dutra, Walderez Ornelas
Gollob, K. J.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira, É. L. M.
Keesen, T. S. L.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Carvalho Filho, Edgar Marcelino de
Dutra, Walderez Ornelas
Gollob, K. J.
Vieira, É. L. M.
Keesen, T. S. L.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Carvalho Filho, Edgar Marcelino de
Dutra, Walderez Ornelas
Gollob, K. J.
dc.subject.por.fl_str_mv Co-stimulatory molecules
Cutaneous leishmaniasis
Cytokines
Human
Immunoregulation
Leishmania
Monocytes
TLR9
topic Co-stimulatory molecules
Cutaneous leishmaniasis
Cytokines
Human
Immunoregulation
Leishmania
Monocytes
TLR9
description Texto completo: acesso restrito. p. 65–72
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-03-10T19:23:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/17127
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.number.pt_BR.fl_str_mv v. 35, n. 2
identifier_str_mv 0141-9838
v. 35, n. 2
url http://repositorio.ufba.br/ri/handle/ri/17127
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv http://dx.doi.org/10.1111/pim.12012
publisher.none.fl_str_mv http://dx.doi.org/10.1111/pim.12012
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1111/pim.12012
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