In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Barral-Netto, Manoel
Data de Publicação: 1996
Outros Autores: Sohsten, R. L. Von, Teixeira, M., Santos, Washington Luis Conrado dos, Pompeu, M. L., Moreira, R. A., Oliveira, J. T. A., Cavada, B. S., Falcoff, E., Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12895
Resumo: Texto completo. Acesso restrito. p. 237–250
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spelling Barral-Netto, ManoelSohsten, R. L. VonTeixeira, M.Santos, Washington Luis Conrado dosPompeu, M. L.Moreira, R. A.Oliveira, J. T. A.Cavada, B. S.Falcoff, E.Barral, Aldina Maria PradoBarral-Netto, ManoelSohsten, R. L. VonTeixeira, M.Santos, Washington Luis Conrado dosPompeu, M. L.Moreira, R. A.Oliveira, J. T. A.Cavada, B. S.Falcoff, E.Barral, Aldina Maria Prado2013-09-09T20:25:02Z2013-09-09T20:25:02Z19960001-706Xhttp://www.repositorio.ufba.br/ri/handle/ri/12895v. 60, n. 4Texto completo. Acesso restrito. p. 237–250In vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-γ (IFN-γ) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-γ production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-γ administration (although IFN-γ preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-γ neutralization with anti-IFN-γ monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-γ.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-09T20:25:01Z No. of bitstreams: 1 66666666666666666.pdf: 979575 bytes, checksum: dfb8ac628ceaf8c94cb72e73fbaa01d7 (MD5)Made available in DSpace on 2013-09-09T20:25:02Z (GMT). No. of bitstreams: 1 66666666666666666.pdf: 979575 bytes, checksum: dfb8ac628ceaf8c94cb72e73fbaa01d7 (MD5) Previous issue date: 1996SalvadorActa Tropicahttp://www-sciencedirect-com.ez10.periodicos.capes.gov.br/science/article/pii/0001706X95001204reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmania amazonensisLeishmaniasisLeishmaniaTegumentary leishmaniasisExperimental leishmaniasisCanavalia brasiliensisInterferon-γIn vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensisActa Tropicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL66666666666666666.pdf66666666666666666.pdfapplication/pdf979575https://repositorio.ufba.br/bitstream/ri/12895/1/66666666666666666.pdfdfb8ac628ceaf8c94cb72e73fbaa01d7MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12895/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT66666666666666666.pdf.txt66666666666666666.pdf.txtExtracted texttext/plain39198https://repositorio.ufba.br/bitstream/ri/12895/3/66666666666666666.pdf.txt713697e3584ee771b53c0ed72973798bMD53ri/128952022-08-08 13:17:35.872oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:35Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
dc.title.alternative.pt_BR.fl_str_mv Acta Tropica
title In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
spellingShingle In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
Barral-Netto, Manoel
Leishmania amazonensis
Leishmaniasis
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Canavalia brasiliensis
Interferon-γ
title_short In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_full In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_fullStr In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_full_unstemmed In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_sort In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
author Barral-Netto, Manoel
author_facet Barral-Netto, Manoel
Sohsten, R. L. Von
Teixeira, M.
Santos, Washington Luis Conrado dos
Pompeu, M. L.
Moreira, R. A.
Oliveira, J. T. A.
Cavada, B. S.
Falcoff, E.
Barral, Aldina Maria Prado
author_role author
author2 Sohsten, R. L. Von
Teixeira, M.
Santos, Washington Luis Conrado dos
Pompeu, M. L.
Moreira, R. A.
Oliveira, J. T. A.
Cavada, B. S.
Falcoff, E.
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barral-Netto, Manoel
Sohsten, R. L. Von
Teixeira, M.
Santos, Washington Luis Conrado dos
Pompeu, M. L.
Moreira, R. A.
Oliveira, J. T. A.
Cavada, B. S.
Falcoff, E.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Sohsten, R. L. Von
Teixeira, M.
Santos, Washington Luis Conrado dos
Pompeu, M. L.
Moreira, R. A.
Oliveira, J. T. A.
Cavada, B. S.
Falcoff, E.
Barral, Aldina Maria Prado
dc.subject.por.fl_str_mv Leishmania amazonensis
Leishmaniasis
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Canavalia brasiliensis
Interferon-γ
topic Leishmania amazonensis
Leishmaniasis
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Canavalia brasiliensis
Interferon-γ
description Texto completo. Acesso restrito. p. 237–250
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2013-09-09T20:25:02Z
dc.date.available.fl_str_mv 2013-09-09T20:25:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12895
dc.identifier.issn.none.fl_str_mv 0001-706X
dc.identifier.number.pt_BR.fl_str_mv v. 60, n. 4
identifier_str_mv 0001-706X
v. 60, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/12895
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Acta Tropica
publisher.none.fl_str_mv Acta Tropica
dc.source.pt_BR.fl_str_mv http://www-sciencedirect-com.ez10.periodicos.capes.gov.br/science/article/pii/0001706X95001204
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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