Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice

Detalhes bibliográficos
Autor(a) principal: Pompeu, M. L.
Data de Publicação: 1992
Outros Autores: Freitas, L. A., Santos, M. L. V., Barral, Aldina Maria Prado, Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7398
Resumo: Texto completo: acesso restrito. p. 169-176
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spelling Pompeu, M. L.Freitas, L. A.Santos, M. L. V.Barral, Aldina Maria PradoBarral-Netto, ManoelPompeu, M. L.Freitas, L. A.Santos, M. L. V.Barral, Aldina Maria PradoBarral-Netto, Manoel2012-12-11T17:34:51Z2012-12-11T17:34:51Z19920014-4894http://www.repositorio.ufba.br/ri/handle/ri/7398v. 74, n. 2Texto completo: acesso restrito. p. 169-176In vitro studies have shown that both macrophage activation and destruction of parasitized macrophages lead to leishmania destruction. The relative role played by such mechanisms in vivo have not been properly evaluated. We took advantage of the model of intravenous immunization with solubilized leishmanial antigen which renders partially resistant the otherwise highly susceptible BALB/c mice to address this issue avoiding the interference of different genetic backgrounds. Leishmania destruction occurred in three situations: destruction of the parasitized macrophage, which were in close contact with lymphocytes or eosinophils; extracellular damage, always surrounded by small foci of granulocytes; and parasite damage inside activated macrophages. Destruction of the parasitized macrophages was frequently seen in immunized and protected animals. Our observations suggest that destruction of parasite-loaded macrophages is an important mechanism of host protection in experimental cutaneous leishmaniasis.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-12-11T17:34:51Z No. of bitstreams: 1 fffff9999.pdf: 3311751 bytes, checksum: 97d1f63631d0cb4cdb12219d0eedd179 (MD5)Made available in DSpace on 2012-12-11T17:34:51Z (GMT). No. of bitstreams: 1 fffff9999.pdf: 3311751 bytes, checksum: 97d1f63631d0cb4cdb12219d0eedd179 (MD5) Previous issue date: 1992SalvadorExperimental Parasitologyhttp://dx.doi.org/10.1016/0014-4894(92)90044-Breponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmania amazonensisLeishmaniasisImmunizationLeishmaniaTegumentary leishmaniasisLeishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c miceExperimental Parasitologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALfffff9999.pdffffff9999.pdfapplication/pdf3311751https://repositorio.ufba.br/bitstream/ri/7398/1/fffff9999.pdf97d1f63631d0cb4cdb12219d0eedd179MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7398/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTfffff9999.pdf.txtfffff9999.pdf.txtExtracted texttext/plain20992https://repositorio.ufba.br/bitstream/ri/7398/3/fffff9999.pdf.txt5b20dc13bc672b0d5576d0b7ca1ac05eMD53ri/73982022-07-05 14:03:11.539oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:11Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
dc.title.alternative.pt_BR.fl_str_mv Experimental Parasitology
title Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
spellingShingle Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
Pompeu, M. L.
Leishmania amazonensis
Leishmaniasis
Immunization
Leishmania
Tegumentary leishmaniasis
title_short Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
title_full Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
title_fullStr Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
title_full_unstemmed Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
title_sort Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice
author Pompeu, M. L.
author_facet Pompeu, M. L.
Freitas, L. A.
Santos, M. L. V.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author_role author
author2 Freitas, L. A.
Santos, M. L. V.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pompeu, M. L.
Freitas, L. A.
Santos, M. L. V.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Pompeu, M. L.
Freitas, L. A.
Santos, M. L. V.
Barral, Aldina Maria Prado
Barral-Netto, Manoel
dc.subject.por.fl_str_mv Leishmania amazonensis
Leishmaniasis
Immunization
Leishmania
Tegumentary leishmaniasis
topic Leishmania amazonensis
Leishmaniasis
Immunization
Leishmania
Tegumentary leishmaniasis
description Texto completo: acesso restrito. p. 169-176
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2012-12-11T17:34:51Z
dc.date.available.fl_str_mv 2012-12-11T17:34:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7398
dc.identifier.issn.none.fl_str_mv 0014-4894
dc.identifier.number.pt_BR.fl_str_mv v. 74, n. 2
identifier_str_mv 0014-4894
v. 74, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/7398
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Experimental Parasitology
publisher.none.fl_str_mv Experimental Parasitology
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/0014-4894(92)90044-B
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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