In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Barral Netto, Manoel
Data de Publicação: 1996
Outros Autores: Von Sohsten, R. L, Teixeira, M, dosSantos, Washington Luis Conrado, Pompeu, Margarida Maria de Lima, Moreira, R. A, Oliveira, J. T, Cavada, Benildo Sousa, Falcoff, E, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7452
Resumo: Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / LAboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
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spelling Barral Netto, ManoelVon Sohsten, R. LTeixeira, MdosSantos, Washington Luis ConradoPompeu, Margarida Maria de LimaMoreira, R. AOliveira, J. TCavada, Benildo SousaFalcoff, EBarral, Aldina Maria Prado2014-03-26T16:41:14Z2014-03-26T16:41:14Z1996BARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/7452engElsevier Science B.VIn vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / LAboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, Brasillnstitut Curie. Unitk INSERM. PAris, FranceUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilIn vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-gamma (IFN-gamma) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-gamma production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-gamma administration (although IFN-gamma preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-gamma neutralization with anti-IFN-gamma monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-gamma.LeishmaniasisLeishmaniaTegumentary leishmaniasisExperimental leishmaniasisCanavalia brasiliensisInterferon-yAnimaisFemininoInterferon gama/biossínteseLectinas/uso terapêuticoLeishmania mexicanaLeishmaniose Cutânea/terapiaInterferon gama/farmacocinéticaLeishmaniose Cutânea/imunologiaLeishmaniose Cutânea/parasitologiaMacrófagos Peritoneais/efeitos de drogasMacrófagos Peritoneais/parasitologiaCamundongosCamundongos Endogâmicos BALB CRatosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral-Netto M In vivo protective effect of the lectin....pdfBarral-Netto M In vivo protective effect of the lectin....pdfapplication/pdf979575https://www.arca.fiocruz.br/bitstream/icict/7452/1/Barral-Netto%20M%20In%20vivo%20protective%20effect%20of%20the%20lectin....pdfdfb8ac628ceaf8c94cb72e73fbaa01d7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7452/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarral-Netto M In vivo protective effect of the lectin....pdf.txtBarral-Netto M In vivo protective effect of the lectin....pdf.txtExtracted texttext/plain39193https://www.arca.fiocruz.br/bitstream/icict/7452/5/Barral-Netto%20M%20In%20vivo%20protective%20effect%20of%20the%20lectin....pdf.txta2c82d52dabd87eef66b4d35d93d4aeaMD55THUMBNAILBarral-Netto M In vivo protective effect of the lectin....pdf.jpgBarral-Netto M In vivo protective effect of the lectin....pdf.jpgGenerated Thumbnailimage/jpeg2312https://www.arca.fiocruz.br/bitstream/icict/7452/4/Barral-Netto%20M%20In%20vivo%20protective%20effect%20of%20the%20lectin....pdf.jpgb3bbaac09454e640df268525f2fd532eMD54icict/74522023-03-15 14:33:12.191oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
spellingShingle In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
Barral Netto, Manoel
Leishmaniasis
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Canavalia brasiliensis
Interferon-y
Animais
Feminino
Interferon gama/biossíntese
Lectinas/uso terapêutico
Leishmania mexicana
Leishmaniose Cutânea/terapia
Interferon gama/farmacocinética
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/parasitologia
Macrófagos Peritoneais/efeitos de drogas
Macrófagos Peritoneais/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Ratos
title_short In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_full In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_fullStr In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_full_unstemmed In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
title_sort In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
author Barral Netto, Manoel
author_facet Barral Netto, Manoel
Von Sohsten, R. L
Teixeira, M
dosSantos, Washington Luis Conrado
Pompeu, Margarida Maria de Lima
Moreira, R. A
Oliveira, J. T
Cavada, Benildo Sousa
Falcoff, E
Barral, Aldina Maria Prado
author_role author
author2 Von Sohsten, R. L
Teixeira, M
dosSantos, Washington Luis Conrado
Pompeu, Margarida Maria de Lima
Moreira, R. A
Oliveira, J. T
Cavada, Benildo Sousa
Falcoff, E
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barral Netto, Manoel
Von Sohsten, R. L
Teixeira, M
dosSantos, Washington Luis Conrado
Pompeu, Margarida Maria de Lima
Moreira, R. A
Oliveira, J. T
Cavada, Benildo Sousa
Falcoff, E
Barral, Aldina Maria Prado
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Canavalia brasiliensis
Interferon-y
Animais
Feminino
topic Leishmaniasis
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Canavalia brasiliensis
Interferon-y
Animais
Feminino
Interferon gama/biossíntese
Lectinas/uso terapêutico
Leishmania mexicana
Leishmaniose Cutânea/terapia
Interferon gama/farmacocinética
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/parasitologia
Macrófagos Peritoneais/efeitos de drogas
Macrófagos Peritoneais/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Ratos
dc.subject.decs.pt_BR.fl_str_mv Interferon gama/biossíntese
Lectinas/uso terapêutico
Leishmania mexicana
Leishmaniose Cutânea/terapia
Interferon gama/farmacocinética
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/parasitologia
Macrófagos Peritoneais/efeitos de drogas
Macrófagos Peritoneais/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Ratos
description Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / LAboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2014-03-26T16:41:14Z
dc.date.available.fl_str_mv 2014-03-26T16:41:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7452
dc.identifier.issn.none.fl_str_mv 0001-706X
identifier_str_mv BARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996.
0001-706X
url https://www.arca.fiocruz.br/handle/icict/7452
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dc.publisher.none.fl_str_mv Elsevier Science B.V
publisher.none.fl_str_mv Elsevier Science B.V
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