Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats

Detalhes bibliográficos
Autor(a) principal: Castro, Letícia
Data de Publicação: 2003
Outros Autores: Athanazio, Rodrigo Abensur, Barbetta, Marcelo Campos, Ramos, Ana Claudia, Angelo, Ana Luiza Dias, Campos, Igor, Varjão, Bruno, Ferreira, Hilda Silva, Fregoneze, Josmara, Castro e Silva, Emilio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14183
Resumo: Texto completo: acesso restrito. p. 151–159
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spelling Castro, LetíciaAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposRamos, Ana ClaudiaAngelo, Ana Luiza DiasCampos, IgorVarjão, BrunoFerreira, Hilda SilvaFregoneze, JosmaraCastro e Silva, Emilio deCastro, LetíciaAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposRamos, Ana ClaudiaAngelo, Ana Luiza DiasCampos, IgorVarjão, BrunoFerreira, Hilda SilvaFregoneze, JosmaraCastro e Silva, Emilio de2013-12-16T13:41:36Z2003http://repositorio.ufba.br/ri/handle/ri/14183v. 981, n. 1-2Texto completo: acesso restrito. p. 151–159In the present study, we investigated the participation of central 5-HT2B/2C and 5-HT3 receptors in the salt intake induced by sodium depletion in Wistar male rats. Sodium depletion was produced by the administration of furosemide associated with a low salt diet. Third ventricle injections of mCPP, a 5-HT2B/2C agonist, at doses of 80, 160 and 240 nmol, promoted a dose-dependent reduction in salt intake in sodium-depleted rats. The inhibitory effect produced by central administration of mCPP was abolished by the central pretreatment with SDZ SER 082, a 5-HT2B/2C antagonist. Similar results were obtained with third ventricle injections of m-CPBG (80, 160 and 240 nmol), a selective 5-HT3 agonist that also induced a dose-related decrease in salt intake in sodium-depleted rats. The central pretreatment with LY-278,584, a selective 5-HT3 receptor antagonist, was able to impair the salt intake inhibition elicited by third ventricle injections of m-CPBG. Central administration of each one of the antagonists alone or a combination of both antagonists together did not significantly change salt intake after sodium depletion. On the other hand, the central administration of both mCPP and m-CPBG, in the highest dose used to test their effect on salt intake (240 nmol), was unable to modify blood pressure in sodium-depleted rats. It is concluded that: (1) pharmacological activation of central 5-HT2B/2C and 5-HT3 receptors diminishes salt intake during sodium depletion, (2) an inhibitory endogenous drive exerted by central 5-HT2B/2C and 5-HT3 receptors does not seem to exist and (3) the reduction in salt intake generated by the pharmacological activation of these central receptors is not produced by an acute hypertensive response.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-12-16T13:32:25Z No. of bitstreams: 1 Letícia Castro.pdf: 266378 bytes, checksum: 5c7ea051e0c5114072ae32a3e5b34927 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2013-12-16T13:41:36Z (GMT) No. of bitstreams: 1 Letícia Castro.pdf: 266378 bytes, checksum: 5c7ea051e0c5114072ae32a3e5b34927 (MD5)Made available in DSpace on 2013-12-16T13:41:36Z (GMT). No. of bitstreams: 1 Letícia Castro.pdf: 266378 bytes, checksum: 5c7ea051e0c5114072ae32a3e5b34927 (MD5) Previous issue date: 2003http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0006-8993(03)03015-4reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASodium appetiteSerotoninSodium depletionCentral 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted ratsBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALLetícia Castro.pdfLetícia Castro.pdfapplication/pdf266378https://repositorio.ufba.br/bitstream/ri/14183/1/Let%c3%adcia%20Castro.pdf5c7ea051e0c5114072ae32a3e5b34927MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14183/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTLetícia Castro.pdf.txtLetícia Castro.pdf.txtExtracted texttext/plain41080https://repositorio.ufba.br/bitstream/ri/14183/3/Let%c3%adcia%20Castro.pdf.txte5c2be3511b8df62bea4ea408562a988MD53ri/141832022-08-08 13:17:45.4oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:45Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
dc.title.alternative.pt_BR.fl_str_mv Brain Research
title Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
spellingShingle Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
Castro, Letícia
Sodium appetite
Serotonin
Sodium depletion
title_short Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
title_full Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
title_fullStr Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
title_full_unstemmed Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
title_sort Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats
author Castro, Letícia
author_facet Castro, Letícia
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, Ana Claudia
Angelo, Ana Luiza Dias
Campos, Igor
Varjão, Bruno
Ferreira, Hilda Silva
Fregoneze, Josmara
Castro e Silva, Emilio de
author_role author
author2 Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, Ana Claudia
Angelo, Ana Luiza Dias
Campos, Igor
Varjão, Bruno
Ferreira, Hilda Silva
Fregoneze, Josmara
Castro e Silva, Emilio de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Letícia
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, Ana Claudia
Angelo, Ana Luiza Dias
Campos, Igor
Varjão, Bruno
Ferreira, Hilda Silva
Fregoneze, Josmara
Castro e Silva, Emilio de
Castro, Letícia
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, Ana Claudia
Angelo, Ana Luiza Dias
Campos, Igor
Varjão, Bruno
Ferreira, Hilda Silva
Fregoneze, Josmara
Castro e Silva, Emilio de
dc.subject.por.fl_str_mv Sodium appetite
Serotonin
Sodium depletion
topic Sodium appetite
Serotonin
Sodium depletion
description Texto completo: acesso restrito. p. 151–159
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2013-12-16T13:41:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14183
dc.identifier.number.pt_BR.fl_str_mv v. 981, n. 1-2
url http://repositorio.ufba.br/ri/handle/ri/14183
identifier_str_mv v. 981, n. 1-2
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0006-8993(03)03015-4
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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