Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas

Detalhes bibliográficos
Autor(a) principal: Rocha, Flávia Godinho Costa Wanderley
Data de Publicação: 2023
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da UFBA
Texto Completo: https://repositorio.ufba.br/handle/ri/38873
Resumo: Introdução – Os fármacos antirreabsortivos são medicações frequentemente utilizadas no tratamento de desordens ósseas e de neoplasias malignas metastásicas. No entanto, o uso crônico desses medicamentos pode resultar em osteonecrose dos maxilares. Dentre esses medicamentos da classe antirreabsortiva, têm se destacado os bisfosfonatos e os denosumabes. Objetivo – Verificar o nível de informações técnico-científicas dos cirurgiões-dentistas que exercem suas atividades profissionais no estado da Bahia (Brasil) sobre medicamentos antirreabsortivos e procedimentos farmacológicos indicados visando à prevenção da osteonecrose dos maxilares e o tratamento das sequelas medicamentosas que possam ocorrer, considerando o tempo de formado em Odontologia e a titulação acadêmica destes profissionais. Metodologia – Trata-se de um estudo transversal quantitativo. Nele, foram consultados 339 dentistas por meio de um questionário virtual com tópicos de caráter pessoal e profissional, elementos contidos na anamnese realizada e o conhecimento acerca dos fármacos antirreabsortivos, incluindo indicações, efeitos adversos e tratamentos empregados. Foram realizados os testes de qui-quadrado e exato de Fisher para analisar as associações dos dados descritos por frequências absoluta e relativa com o tempo de formado dos profissionais. Todas as análises foram feitas no programa R, com nível de significância de 5%. Resultados – Entre os 339 participantes da pesquisa, a maioria era do sexo feminino (76,4%), com faixa etária de 31-35 anos (25,1%). Ademais, uma grande parte dos profissionais tinha graduação em odontologia obtida na categoria Universidade (49,0%), no estado da Bahia (80,5%). Em relação às variáveis relacionadas ao desempenho profissional, aqueles que possuíam maior titulação, foram os que demonstraram conhecimento máximo dos fármacos antirreabsortivos ou revelaram que, de alguma forma, tinham informações sobre os mesmos (p<0,05). Conclusão – Os cirurgiões-dentistas do Brasil que têm mais de cinco anos de graduação e maior titulação acadêmica possuem mais informações científicas sobre os medicamentos antirreabsortivos e procedimentos farmacológicos, o que pode contribuir positivamente para a prevenção da osteonecrose dos maxilares e o tratamento das sequelas medicamentosas que possam ocorrer. Adicionalmente, este atual trabalho alerta para a necessidade de evidenciar mais nos cursos de graduação em odontologia os assuntos referentes aos fármacos antirreabsortivos, pois se necessita de profissionais com competências para evitar e ou interromper as graves sequelas que possam ocorrer nos maxilares dos indivíduos que utilizam esses medicamentos.
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spelling 2024-01-15T13:50:45Z2024-01-15T13:50:45Z2023-12-13ROCHA, Flávia Godinho Costa Wanderley. Medicamentos antirreabsortivos: perfil técnico científico dos cirurgiões-dentistas. 112 f. 2023. Tese (Doutorado) - Universidade Federal da Bahia, Instituto de Ciências da Saúde, Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Salvador, 2023.https://repositorio.ufba.br/handle/ri/38873Introdução – Os fármacos antirreabsortivos são medicações frequentemente utilizadas no tratamento de desordens ósseas e de neoplasias malignas metastásicas. No entanto, o uso crônico desses medicamentos pode resultar em osteonecrose dos maxilares. Dentre esses medicamentos da classe antirreabsortiva, têm se destacado os bisfosfonatos e os denosumabes. Objetivo – Verificar o nível de informações técnico-científicas dos cirurgiões-dentistas que exercem suas atividades profissionais no estado da Bahia (Brasil) sobre medicamentos antirreabsortivos e procedimentos farmacológicos indicados visando à prevenção da osteonecrose dos maxilares e o tratamento das sequelas medicamentosas que possam ocorrer, considerando o tempo de formado em Odontologia e a titulação acadêmica destes profissionais. Metodologia – Trata-se de um estudo transversal quantitativo. Nele, foram consultados 339 dentistas por meio de um questionário virtual com tópicos de caráter pessoal e profissional, elementos contidos na anamnese realizada e o conhecimento acerca dos fármacos antirreabsortivos, incluindo indicações, efeitos adversos e tratamentos empregados. Foram realizados os testes de qui-quadrado e exato de Fisher para analisar as associações dos dados descritos por frequências absoluta e relativa com o tempo de formado dos profissionais. Todas as análises foram feitas no programa R, com nível de significância de 5%. Resultados – Entre os 339 participantes da pesquisa, a maioria era do sexo feminino (76,4%), com faixa etária de 31-35 anos (25,1%). Ademais, uma grande parte dos profissionais tinha graduação em odontologia obtida na categoria Universidade (49,0%), no estado da Bahia (80,5%). Em relação às variáveis relacionadas ao desempenho profissional, aqueles que possuíam maior titulação, foram os que demonstraram conhecimento máximo dos fármacos antirreabsortivos ou revelaram que, de alguma forma, tinham informações sobre os mesmos (p<0,05). Conclusão – Os cirurgiões-dentistas do Brasil que têm mais de cinco anos de graduação e maior titulação acadêmica possuem mais informações científicas sobre os medicamentos antirreabsortivos e procedimentos farmacológicos, o que pode contribuir positivamente para a prevenção da osteonecrose dos maxilares e o tratamento das sequelas medicamentosas que possam ocorrer. Adicionalmente, este atual trabalho alerta para a necessidade de evidenciar mais nos cursos de graduação em odontologia os assuntos referentes aos fármacos antirreabsortivos, pois se necessita de profissionais com competências para evitar e ou interromper as graves sequelas que possam ocorrer nos maxilares dos indivíduos que utilizam esses medicamentos.Introduction - Antiresorptive drugs are medications frequently used in the treatment of bone disorders and metastatic malignancies. However, chronic use of these medications can result in osteonecrosis of the jaws. Among the drugs of the antiresorptive class, bisphosphonates and denosumabs have stood out. Objective - To determine the level of scientific information of dental surgeons who carry out their professional activities in the state of Bahia (Brazil) about antiresorptive drugs and indicated pharmacological procedures aiming at the prevention of osteonecrosis of the jaws and the therapy of drug sequelae that may occur, considering the time since graduation in Dentistry and the academic qualification of these professionals. Methodology - This is a quantitative cross-sectional study in which 339 dentists were consulted using the virtual questionnaire containing topics of personal nature and professional, elements contained in the anamnesis carried out and knowledge about antiresorptive drugs, including indications, adverse effects and treatments applied. Chi-square and Fisher's exact tests were performed to analyze associations of data described by absolute and relative frequencies with professionals' time since graduation. All analyses were performed using the R software, with 5% significance level. Results - Among the 339 survey participants, the majority were female (76.4%), aged 31-35 years (25.1%). Furthermore, a large part of the professionals had a degree in dentistry obtained in the University category (49.0%), in the state of Bahia (80.5%). In relation to variables related to professional performance, those ones who revealed to have graduated for more than five years with the highest academic degree were those who demonstrated maximum knowledge of antiresorptive drugs or revealed that somehow, they had information about them (p<0,05). Conclusion - Dental surgeons in Brazil who have more than five years since graduation have more scientific information about antiresorptive drugs and pharmacological procedures, which can positively contribute to the prevention of osteonecrosis of the jaws and treatment of drug sequelae that may occur. Additionally, this current work highlights the need to highlight more in undergraduate dentistry courses the issues relating to antiresorptive drugs, as professionals with skills are needed to avoid and or interrupt the serious sequelae that may occur in the jaws of individuals who use these medications.Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB)porUniversidade Federal da BahiaPrograma de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas (PPGORGSISTEM) UFBABrasilInstituto de Ciências da Saúde - ICSKnowledgeDentistsBisphosphonatesDiphosphonatesAntiresorptive drugsBone Density Conservation AgentsOsteonecrosisCNPQ::CIENCIAS BIOLOGICASCNPQ::CIENCIAS DA SAÚDEConhecimentoOdontólogosBisfosfonatosDifosfonatosMedicamentos antirreabsortivosConservadores da densidade ósseaOsteonecroseMedicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistasDoutoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionAraújo, Roberto Paulo Correia dehttp://lattes.cnpq.br/8389914651900629Araújo, Roberto Paulo Correia deSilva, Daniela Nascimentohttp://lattes.cnpq.br/3613001852759565Mello, Sandra Maria Ferrazhttp://lattes.cnpq.br/4661074667104305Fernandes, Atson Carlos de Souzahttp://lattes.cnpq.br/8458546406023605Araújo, Danilo Barral dehttp://lattes.cnpq.br/1197511486365047Aguiar, Márcio Cajazeirahttp://lattes.cnpq.br/5406678886333526http://lattes.cnpq.br/8389914651900629http://lattes.cnpq.br/5254842464226381Rocha, Flávia Godinho Costa Wanderley1. 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dc.title.pt_BR.fl_str_mv Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
title Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
spellingShingle Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
Rocha, Flávia Godinho Costa Wanderley
CNPQ::CIENCIAS BIOLOGICAS
CNPQ::CIENCIAS DA SAÚDE
Conhecimento
Odontólogos
Bisfosfonatos
Difosfonatos
Medicamentos antirreabsortivos
Conservadores da densidade óssea
Osteonecrose
Knowledge
Dentists
Bisphosphonates
Diphosphonates
Antiresorptive drugs
Bone Density Conservation Agents
Osteonecrosis
title_short Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
title_full Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
title_fullStr Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
title_full_unstemmed Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
title_sort Medicamentos antirreabsortivos: perfil técnico-científico dos cirurgiões-dentistas
author Rocha, Flávia Godinho Costa Wanderley
author_facet Rocha, Flávia Godinho Costa Wanderley
author_role author
dc.contributor.refereesLattes.pt_BR.fl_str_mv http://lattes.cnpq.br/8389914651900629
dc.contributor.advisor1.fl_str_mv Araújo, Roberto Paulo Correia de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/8389914651900629
dc.contributor.referee1.fl_str_mv Araújo, Roberto Paulo Correia de
Silva, Daniela Nascimento
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/3613001852759565
dc.contributor.referee2.fl_str_mv Mello, Sandra Maria Ferraz
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/4661074667104305
dc.contributor.referee3.fl_str_mv Fernandes, Atson Carlos de Souza
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/8458546406023605
dc.contributor.referee4.fl_str_mv Araújo, Danilo Barral de
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/1197511486365047
dc.contributor.referee5.fl_str_mv Aguiar, Márcio Cajazeira
dc.contributor.referee5Lattes.fl_str_mv http://lattes.cnpq.br/5406678886333526
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5254842464226381
dc.contributor.author.fl_str_mv Rocha, Flávia Godinho Costa Wanderley
contributor_str_mv Araújo, Roberto Paulo Correia de
Araújo, Roberto Paulo Correia de
Silva, Daniela Nascimento
Mello, Sandra Maria Ferraz
Fernandes, Atson Carlos de Souza
Araújo, Danilo Barral de
Aguiar, Márcio Cajazeira
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS BIOLOGICAS
CNPQ::CIENCIAS DA SAÚDE
topic CNPQ::CIENCIAS BIOLOGICAS
CNPQ::CIENCIAS DA SAÚDE
Conhecimento
Odontólogos
Bisfosfonatos
Difosfonatos
Medicamentos antirreabsortivos
Conservadores da densidade óssea
Osteonecrose
Knowledge
Dentists
Bisphosphonates
Diphosphonates
Antiresorptive drugs
Bone Density Conservation Agents
Osteonecrosis
dc.subject.por.fl_str_mv Conhecimento
Odontólogos
Bisfosfonatos
Difosfonatos
Medicamentos antirreabsortivos
Conservadores da densidade óssea
Osteonecrose
dc.subject.other.pt_BR.fl_str_mv Knowledge
Dentists
Bisphosphonates
Diphosphonates
Antiresorptive drugs
Bone Density Conservation Agents
Osteonecrosis
description Introdução – Os fármacos antirreabsortivos são medicações frequentemente utilizadas no tratamento de desordens ósseas e de neoplasias malignas metastásicas. No entanto, o uso crônico desses medicamentos pode resultar em osteonecrose dos maxilares. Dentre esses medicamentos da classe antirreabsortiva, têm se destacado os bisfosfonatos e os denosumabes. Objetivo – Verificar o nível de informações técnico-científicas dos cirurgiões-dentistas que exercem suas atividades profissionais no estado da Bahia (Brasil) sobre medicamentos antirreabsortivos e procedimentos farmacológicos indicados visando à prevenção da osteonecrose dos maxilares e o tratamento das sequelas medicamentosas que possam ocorrer, considerando o tempo de formado em Odontologia e a titulação acadêmica destes profissionais. Metodologia – Trata-se de um estudo transversal quantitativo. Nele, foram consultados 339 dentistas por meio de um questionário virtual com tópicos de caráter pessoal e profissional, elementos contidos na anamnese realizada e o conhecimento acerca dos fármacos antirreabsortivos, incluindo indicações, efeitos adversos e tratamentos empregados. Foram realizados os testes de qui-quadrado e exato de Fisher para analisar as associações dos dados descritos por frequências absoluta e relativa com o tempo de formado dos profissionais. Todas as análises foram feitas no programa R, com nível de significância de 5%. Resultados – Entre os 339 participantes da pesquisa, a maioria era do sexo feminino (76,4%), com faixa etária de 31-35 anos (25,1%). Ademais, uma grande parte dos profissionais tinha graduação em odontologia obtida na categoria Universidade (49,0%), no estado da Bahia (80,5%). Em relação às variáveis relacionadas ao desempenho profissional, aqueles que possuíam maior titulação, foram os que demonstraram conhecimento máximo dos fármacos antirreabsortivos ou revelaram que, de alguma forma, tinham informações sobre os mesmos (p<0,05). Conclusão – Os cirurgiões-dentistas do Brasil que têm mais de cinco anos de graduação e maior titulação acadêmica possuem mais informações científicas sobre os medicamentos antirreabsortivos e procedimentos farmacológicos, o que pode contribuir positivamente para a prevenção da osteonecrose dos maxilares e o tratamento das sequelas medicamentosas que possam ocorrer. Adicionalmente, este atual trabalho alerta para a necessidade de evidenciar mais nos cursos de graduação em odontologia os assuntos referentes aos fármacos antirreabsortivos, pois se necessita de profissionais com competências para evitar e ou interromper as graves sequelas que possam ocorrer nos maxilares dos indivíduos que utilizam esses medicamentos.
publishDate 2023
dc.date.issued.fl_str_mv 2023-12-13
dc.date.accessioned.fl_str_mv 2024-01-15T13:50:45Z
dc.date.available.fl_str_mv 2024-01-15T13:50:45Z
dc.type.driver.fl_str_mv Doutorado
info:eu-repo/semantics/doctoralThesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROCHA, Flávia Godinho Costa Wanderley. Medicamentos antirreabsortivos: perfil técnico científico dos cirurgiões-dentistas. 112 f. 2023. Tese (Doutorado) - Universidade Federal da Bahia, Instituto de Ciências da Saúde, Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Salvador, 2023.
dc.identifier.uri.fl_str_mv https://repositorio.ufba.br/handle/ri/38873
identifier_str_mv ROCHA, Flávia Godinho Costa Wanderley. Medicamentos antirreabsortivos: perfil técnico científico dos cirurgiões-dentistas. 112 f. 2023. Tese (Doutorado) - Universidade Federal da Bahia, Instituto de Ciências da Saúde, Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Salvador, 2023.
url https://repositorio.ufba.br/handle/ri/38873
dc.language.iso.fl_str_mv por
language por
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Bone Joint J. 2016; 98B(2):160-5. doi: 10.1302/0301-620X.98B2.36161 38. Bekker PJ, Holloway DL, Rasmussen AS, Murphy R, Martin SW, Leese PT, et al. A single‐dose placebo‐ controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res. 2004;19(7):1059-66. doi: 10.1359/JBMR.040305 39. Anastasilakis AD, Makras P, Yavropoulou MP, Tabacco G, Naciu AM, Palermo A. Denosumab discontinuation and the rebound phenomenon: a narrative review. J Clin Med. 2021;10(1):152. doi: 10.3390/jcm10010152 40. Tofé VI, Bagán L, Bagán JV. Osteonecrosis of the jaws associated with denosumab: Study of clinical and radiographic characteristics in a series of clinical cases. J Clin Exp Dent. 2020;12(7):e676-81. doi: 10.4317/jced.57019 41. Salgueiro M, Stribos M, Zhang LF, Stevens M, Awad ME, Elsalanty M. Value of preoperative CTX serum levels in the prediction of medication-related osteonecrosis of the jaw (MRONJ): a retrospective clinical study. EPMA J. 2019;10(1):21-9. doi: 10.1007/s13167-019-0160-3 42. Kuo TR, Chen CH. Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives. Biomark Res. 2017;5:18. doi: 10.1186/s40364-0170097-4 43. Song M. Dental care for patients taking antiresorptive drugs: a literature review. Restor Dent Endod. 2019;44(4):e42. doi: 10.5395/rde.2019.44.e42 44. Kim HY. Review and update of the risk factors and prevention of antiresorptive-related osteonecrosis of the jaw. Endocrinol Metab (Seoul). 2021; 36(5):917-27. doi: 10.3803/EnM.2021.1170 45. Dimopoulos MA, Kastritis E, Bamia C, Melakopoulos I, Gika D, Roussou M, et al. Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid.Ann Oncol. 2009;20(1):117-20. doi: 10.1093/annonc/mdn554 74 46. Yarom N, Shapiro CL, Peterson DE, Van Poznak CH, Bohlke K, Ruggiero SL, et al. 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