Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12151 |
Resumo: | Texto completo: acesso restrito. p.904–909 |
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Reis, Eliana A. G.Reis, Mitermayer Galvão dosSilva, Rita de Cássia R.Carmo, Theomira Mauadie AzevedoAssis, Ana Marlucia de OliveiraBarreto, Mauricio LimaParraga, Isabel M.Santana, Mônica Leila Portela deBlanton, Ronald EdwardReis, Eliana A. G.Reis, Mitermayer Galvão dosSilva, Rita de Cássia R.Carmo, Theomira Mauadie AzevedoAssis, Ana Marlucia de OliveiraBarreto, Mauricio LimaParraga, Isabel M.Santana, Mônica Leila Portela deBlanton, Ronald Edward2013-07-09T13:51:16Z20060002-9637http://www.repositorio.ufba.br/ri/handle/ri/12151v. 75 n. 5Texto completo: acesso restrito. p.904–909Most Schistosoma mansoni infections are egg-negative after a single dose of oxamniquine. A cohort of 661 infected children was treated at 6-month intervals and assessed for nutritional and parasitological status. Initial biochemical and immunologic markers were measured in a subset of 84 children. All were treated at the start of therapy and at 6 months. Immunoglobulins only served as markers for active infection. No markers were predictive of cure or reinfection, except initial infection intensity and serum low-density lipoprotein. Ten percent were persistently infected and had no change in infection intensity at any time-point. Several factors suggest that this group was biologically different. In addition to failing to reduce their worm burden, they had significantly higher initial intensity of infection (100 versus 65 eggs/g, P = 0.001) and significantly lower initial serum low-density lipoprotein (72 versus 104 mg/dL, P = 0.045). The biologic plausibility of this observation is discussed.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-07-03T13:07:27Z No. of bitstreams: 1 904.full.pdf: 154860 bytes, checksum: 1e2203ed6ee5fecc46e3ad50b5fe23be (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-07-09T13:51:16Z (GMT) No. of bitstreams: 1 904.full.pdf: 154860 bytes, checksum: 1e2203ed6ee5fecc46e3ad50b5fe23be (MD5)Made available in DSpace on 2013-07-09T13:51:16Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni |
| dc.title.alternative.pt_BR.fl_str_mv |
The American Society of Tropical Medicine and Hygiene |
| title |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni |
| spellingShingle |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni Reis, Eliana A. G. Lipoproteins Oxamniquine |
| title_short |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni |
| title_full |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni |
| title_fullStr |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni |
| title_full_unstemmed |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni |
| title_sort |
Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni |
| author |
Reis, Eliana A. G. |
| author_facet |
Reis, Eliana A. G. Reis, Mitermayer Galvão dos Silva, Rita de Cássia R. Carmo, Theomira Mauadie Azevedo Assis, Ana Marlucia de Oliveira Barreto, Mauricio Lima Parraga, Isabel M. Santana, Mônica Leila Portela de Blanton, Ronald Edward |
| author_role |
author |
| author2 |
Reis, Mitermayer Galvão dos Silva, Rita de Cássia R. Carmo, Theomira Mauadie Azevedo Assis, Ana Marlucia de Oliveira Barreto, Mauricio Lima Parraga, Isabel M. Santana, Mônica Leila Portela de Blanton, Ronald Edward |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Reis, Eliana A. G. Reis, Mitermayer Galvão dos Silva, Rita de Cássia R. Carmo, Theomira Mauadie Azevedo Assis, Ana Marlucia de Oliveira Barreto, Mauricio Lima Parraga, Isabel M. Santana, Mônica Leila Portela de Blanton, Ronald Edward Reis, Eliana A. G. Reis, Mitermayer Galvão dos Silva, Rita de Cássia R. Carmo, Theomira Mauadie Azevedo Assis, Ana Marlucia de Oliveira Barreto, Mauricio Lima Parraga, Isabel M. Santana, Mônica Leila Portela de Blanton, Ronald Edward |
| dc.subject.por.fl_str_mv |
Lipoproteins Oxamniquine |
| topic |
Lipoproteins Oxamniquine |
| description |
Texto completo: acesso restrito. p.904–909 |
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2006 |
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2006 |
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2013-07-09T13:51:16Z |
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0002-9637 |
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v. 75 n. 5 |
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0002-9637 v. 75 n. 5 |
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