Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni

Detalhes bibliográficos
Autor(a) principal: Reis, Eliana A. G.
Data de Publicação: 2006
Outros Autores: Reis, Mitermayer Galvão dos, Silva, Rita de Cássia R., Carmo, Theomira Mauadie Azevedo, Assis, Ana Marlucia de Oliveira, Barreto, Mauricio Lima, Parraga, Isabel M., Santana, Mônica Leila Portela de, Blanton, Ronald Edward
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12151
Resumo: Texto completo: acesso restrito. p.904–909
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spelling Reis, Eliana A. G.Reis, Mitermayer Galvão dosSilva, Rita de Cássia R.Carmo, Theomira Mauadie AzevedoAssis, Ana Marlucia de OliveiraBarreto, Mauricio LimaParraga, Isabel M.Santana, Mônica Leila Portela deBlanton, Ronald EdwardReis, Eliana A. G.Reis, Mitermayer Galvão dosSilva, Rita de Cássia R.Carmo, Theomira Mauadie AzevedoAssis, Ana Marlucia de OliveiraBarreto, Mauricio LimaParraga, Isabel M.Santana, Mônica Leila Portela deBlanton, Ronald Edward2013-07-09T13:51:16Z20060002-9637http://www.repositorio.ufba.br/ri/handle/ri/12151v. 75 n. 5Texto completo: acesso restrito. p.904–909Most Schistosoma mansoni infections are egg-negative after a single dose of oxamniquine. A cohort of 661 infected children was treated at 6-month intervals and assessed for nutritional and parasitological status. Initial biochemical and immunologic markers were measured in a subset of 84 children. All were treated at the start of therapy and at 6 months. Immunoglobulins only served as markers for active infection. No markers were predictive of cure or reinfection, except initial infection intensity and serum low-density lipoprotein. Ten percent were persistently infected and had no change in infection intensity at any time-point. Several factors suggest that this group was biologically different. In addition to failing to reduce their worm burden, they had significantly higher initial intensity of infection (100 versus 65 eggs/g, P = 0.001) and significantly lower initial serum low-density lipoprotein (72 versus 104 mg/dL, P = 0.045). The biologic plausibility of this observation is discussed.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-07-03T13:07:27Z No. of bitstreams: 1 904.full.pdf: 154860 bytes, checksum: 1e2203ed6ee5fecc46e3ad50b5fe23be (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-07-09T13:51:16Z (GMT) No. of bitstreams: 1 904.full.pdf: 154860 bytes, checksum: 1e2203ed6ee5fecc46e3ad50b5fe23be (MD5)Made available in DSpace on 2013-07-09T13:51:16Z (GMT). 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dc.title.pt_BR.fl_str_mv Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
dc.title.alternative.pt_BR.fl_str_mv The American Society of Tropical Medicine and Hygiene
title Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
spellingShingle Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
Reis, Eliana A. G.
Lipoproteins
Oxamniquine
title_short Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
title_full Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
title_fullStr Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
title_full_unstemmed Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
title_sort Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
author Reis, Eliana A. G.
author_facet Reis, Eliana A. G.
Reis, Mitermayer Galvão dos
Silva, Rita de Cássia R.
Carmo, Theomira Mauadie Azevedo
Assis, Ana Marlucia de Oliveira
Barreto, Mauricio Lima
Parraga, Isabel M.
Santana, Mônica Leila Portela de
Blanton, Ronald Edward
author_role author
author2 Reis, Mitermayer Galvão dos
Silva, Rita de Cássia R.
Carmo, Theomira Mauadie Azevedo
Assis, Ana Marlucia de Oliveira
Barreto, Mauricio Lima
Parraga, Isabel M.
Santana, Mônica Leila Portela de
Blanton, Ronald Edward
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Eliana A. G.
Reis, Mitermayer Galvão dos
Silva, Rita de Cássia R.
Carmo, Theomira Mauadie Azevedo
Assis, Ana Marlucia de Oliveira
Barreto, Mauricio Lima
Parraga, Isabel M.
Santana, Mônica Leila Portela de
Blanton, Ronald Edward
Reis, Eliana A. G.
Reis, Mitermayer Galvão dos
Silva, Rita de Cássia R.
Carmo, Theomira Mauadie Azevedo
Assis, Ana Marlucia de Oliveira
Barreto, Mauricio Lima
Parraga, Isabel M.
Santana, Mônica Leila Portela de
Blanton, Ronald Edward
dc.subject.por.fl_str_mv Lipoproteins
Oxamniquine
topic Lipoproteins
Oxamniquine
description Texto completo: acesso restrito. p.904–909
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-07-09T13:51:16Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12151
dc.identifier.issn.none.fl_str_mv 0002-9637
dc.identifier.number.pt_BR.fl_str_mv v. 75 n. 5
identifier_str_mv 0002-9637
v. 75 n. 5
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