In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii

Detalhes bibliográficos
Autor(a) principal: Cordeiro, Rossana de Aguiar
Data de Publicação: 2009
Outros Autores: Brilhante, Raimunda Sâmia Nogueira, Rocha, Marcos Fábio Gadelha, Medrano, Delia Jessica Astete, Monteiro, André Jalles, Tavares, Juliane Lira, Lima, Rita Amanda Chaves de, Camargo, Zoilo Pires de, Sidrim, José Júlio Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5278
Resumo: The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinations
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spelling In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasiiAntifúngicosAntituberculososThe aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinationsInternational Journal of Antimicrobial Agents2013-07-08T13:39:38Z2013-07-08T13:39:38Z2009-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCORDEIRO, R. A. et al. In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International Journal of Antimicrobial Agents, v. 34, n. 3, p. 278-280, set. 2009.0924-8579http://www.repositorio.ufc.br/handle/riufc/5278Cordeiro, Rossana de AguiarBrilhante, Raimunda Sâmia NogueiraRocha, Marcos Fábio GadelhaMedrano, Delia Jessica AsteteMonteiro, André JallesTavares, Juliane LiraLima, Rita Amanda Chaves deCamargo, Zoilo Pires deSidrim, José Júlio Costaengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-21T11:10:05Zoai:repositorio.ufc.br:riufc/5278Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2019-01-21T11:10:05Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
title In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
spellingShingle In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
Cordeiro, Rossana de Aguiar
Antifúngicos
Antituberculosos
title_short In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
title_full In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
title_fullStr In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
title_full_unstemmed In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
title_sort In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
author Cordeiro, Rossana de Aguiar
author_facet Cordeiro, Rossana de Aguiar
Brilhante, Raimunda Sâmia Nogueira
Rocha, Marcos Fábio Gadelha
Medrano, Delia Jessica Astete
Monteiro, André Jalles
Tavares, Juliane Lira
Lima, Rita Amanda Chaves de
Camargo, Zoilo Pires de
Sidrim, José Júlio Costa
author_role author
author2 Brilhante, Raimunda Sâmia Nogueira
Rocha, Marcos Fábio Gadelha
Medrano, Delia Jessica Astete
Monteiro, André Jalles
Tavares, Juliane Lira
Lima, Rita Amanda Chaves de
Camargo, Zoilo Pires de
Sidrim, José Júlio Costa
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cordeiro, Rossana de Aguiar
Brilhante, Raimunda Sâmia Nogueira
Rocha, Marcos Fábio Gadelha
Medrano, Delia Jessica Astete
Monteiro, André Jalles
Tavares, Juliane Lira
Lima, Rita Amanda Chaves de
Camargo, Zoilo Pires de
Sidrim, José Júlio Costa
dc.subject.por.fl_str_mv Antifúngicos
Antituberculosos
topic Antifúngicos
Antituberculosos
description The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinations
publishDate 2009
dc.date.none.fl_str_mv 2009-09
2013-07-08T13:39:38Z
2013-07-08T13:39:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CORDEIRO, R. A. et al. In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International Journal of Antimicrobial Agents, v. 34, n. 3, p. 278-280, set. 2009.
0924-8579
http://www.repositorio.ufc.br/handle/riufc/5278
identifier_str_mv CORDEIRO, R. A. et al. In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International Journal of Antimicrobial Agents, v. 34, n. 3, p. 278-280, set. 2009.
0924-8579
url http://www.repositorio.ufc.br/handle/riufc/5278
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Journal of Antimicrobial Agents
publisher.none.fl_str_mv International Journal of Antimicrobial Agents
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1809935804149006336

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