Biflorin : an o-naphthoquinone of clinical significance

Detalhes bibliográficos
Autor(a) principal: Wisintainer, Gabrielle G. N. S.
Data de Publicação: 2014
Outros Autores: Simões, Evelyne R. B., Lemos, Telma L. G., Moura, Sidnei, Souza, Luciana G. S., Fonseca, Aluisio M., Moraes Filho, Manoel Odorico de, Pessoa, Claudia, Roesch-Ely, Mariana, Henriques, João A. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/18735
Resumo: Biflorin is an o -naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plant Capraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against gram- positive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.
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spelling Biflorin : an o-naphthoquinone of clinical significanceSarcoma 180Raízes de PlantasBiflorin is an o -naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plant Capraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against gram- positive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.A biflorina é uma o -naftoquinona com comprovados efeitos citotóxicos frente a células tumorais além de atividades antimicrobiana, antitumoral e antimutagênica. A biflorina é um composto isolado das raízes da planta Capraria biflora L. (Schrophulariaceae), originária das Antilhas e da América do Sul, que está localizada em zonas temperadas e tropicais. Este composto mostrou uma potente atividade contra microorganismos gram-positivos e bactérias álcool-ácido resistentes. Tem mostrado eficiência em inibir a proliferação celular em linhagens tumorais CEM, HL-60, B16, HCT-8, MCF-7. Recentemente, a linhagem tumoral SK-Br3 foi tratada com biflorina e demonstrou importante efeito citotóxico. Neste artigo, relatamos informações relacionadas com os primeiros estudos de caracterização estrutural, bem como os últimos relatos sobre a atividade biológica desta moléculaAnais da Academia Brasileira de Ciências2016-07-27T14:12:50Z2016-07-27T14:12:50Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfWISINTAINER, G. G. N. S. et al. Biflorin : an o-naphthoquinone of clinical significance. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 86, n. 4, p. 1907-1914, 2014.Printed version 0001-3765Online version 1678-2690http://www.repositorio.ufc.br/handle/riufc/18735Wisintainer, Gabrielle G. N. S.Simões, Evelyne R. B.Lemos, Telma L. G.Moura, SidneiSouza, Luciana G. S.Fonseca, Aluisio M.Moraes Filho, Manoel Odorico dePessoa, ClaudiaRoesch-Ely, MarianaHenriques, João A. P.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-11-10T22:56:16Zoai:repositorio.ufc.br:riufc/18735Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:33:36.100251Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Biflorin : an o-naphthoquinone of clinical significance
title Biflorin : an o-naphthoquinone of clinical significance
spellingShingle Biflorin : an o-naphthoquinone of clinical significance
Wisintainer, Gabrielle G. N. S.
Sarcoma 180
Raízes de Plantas
title_short Biflorin : an o-naphthoquinone of clinical significance
title_full Biflorin : an o-naphthoquinone of clinical significance
title_fullStr Biflorin : an o-naphthoquinone of clinical significance
title_full_unstemmed Biflorin : an o-naphthoquinone of clinical significance
title_sort Biflorin : an o-naphthoquinone of clinical significance
author Wisintainer, Gabrielle G. N. S.
author_facet Wisintainer, Gabrielle G. N. S.
Simões, Evelyne R. B.
Lemos, Telma L. G.
Moura, Sidnei
Souza, Luciana G. S.
Fonseca, Aluisio M.
Moraes Filho, Manoel Odorico de
Pessoa, Claudia
Roesch-Ely, Mariana
Henriques, João A. P.
author_role author
author2 Simões, Evelyne R. B.
Lemos, Telma L. G.
Moura, Sidnei
Souza, Luciana G. S.
Fonseca, Aluisio M.
Moraes Filho, Manoel Odorico de
Pessoa, Claudia
Roesch-Ely, Mariana
Henriques, João A. P.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wisintainer, Gabrielle G. N. S.
Simões, Evelyne R. B.
Lemos, Telma L. G.
Moura, Sidnei
Souza, Luciana G. S.
Fonseca, Aluisio M.
Moraes Filho, Manoel Odorico de
Pessoa, Claudia
Roesch-Ely, Mariana
Henriques, João A. P.
dc.subject.por.fl_str_mv Sarcoma 180
Raízes de Plantas
topic Sarcoma 180
Raízes de Plantas
description Biflorin is an o -naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plant Capraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against gram- positive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.
publishDate 2014
dc.date.none.fl_str_mv 2014
2016-07-27T14:12:50Z
2016-07-27T14:12:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv WISINTAINER, G. G. N. S. et al. Biflorin : an o-naphthoquinone of clinical significance. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 86, n. 4, p. 1907-1914, 2014.
Printed version 0001-3765
Online version 1678-2690
http://www.repositorio.ufc.br/handle/riufc/18735
identifier_str_mv WISINTAINER, G. G. N. S. et al. Biflorin : an o-naphthoquinone of clinical significance. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 86, n. 4, p. 1907-1914, 2014.
Printed version 0001-3765
Online version 1678-2690
url http://www.repositorio.ufc.br/handle/riufc/18735
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Anais da Academia Brasileira de Ciências
publisher.none.fl_str_mv Anais da Academia Brasileira de Ciências
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813028854905700352

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