Anticonvulsant activity of thymoquinone and its structural analogues.

• Autor(a) principal: SOUSA, Damião Pergentino de.
• Data de Publicação: 2011
• Outros Autores: NÓBREGA, Franklin Ferreira de Farias., SANTOS, Camila C. M. P., BENEDITO, Rubens Batista., VIEIRA, Ygor W., ULIANA, Marciana Pierina, BROCKSON, Timothy John., ALMEIDA, Reinaldo Nóbrega de.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFCG
• Texto Completo: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227
• topic: Quinonas; Atividade anticonvulsivante; Seizures; Convulsões; Sistema nervoso central; Central nervous system; Structure-activity relationships; Oils; Óleos; Quinones; Anticonvulsant activity; Seizures; Convulsions; Central nervous system; Central nervous system; Structure-activity relationships; Oils; Farmácia.; Química.

It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity of thymoquinone. The unsubstituted para-benzoquinone was the compound that exhibited the highest potency, while 2-methyl-p-benzoquinone was inactive. It was found that the presence of alkyl groups attached to the ring influence the pharmacological activity of the para-benzoquinones. In addition, the number, position, and size of these groups change the anticonvulsant potency of the compounds.