Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFC |
Texto Completo: | http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16565 |
Resumo: | With the use of sensitive imaging methods, there is an increase in thyroid nodules diagnosed. Even the CDT (differentiated thyroid cancer) being proportionately rare, its incidence is increasing, especially small tumors whose clinical outcome is uncertain. It is observed that in clinical practice most patients with CDT develops well when properly treated, mortality rates similar to the general population. On the other hand, a non-negligible percentage has relapses and some eventually not respond to conventional therapies, and died. It can be seen that with the need to identify markers that can predict the behavior of tumors, mainly due to the variable clinical disease progression. With these data, some researchers in search of these markers, are studying a possible relationship of hormonal and reproductive factors in the evolution of CDT. This study analyzes the immunoreactivity of α estrogen receptor (ERα) and progesterone receptor (PR), correlating it with clinical features in 80 female and male patients with papillary thyroid cancer (PDT) and follicular thyroid cancer (FDT ) with materials related to thyroidectomy pieces performed at the University Hospital Walter CantÃdio (HUWC) in the period from 2010 to 2014. There was a predominance of female patients (87.5%), older than or equal to 40 years (68.57%), average age 49.12, tumor size> 1 cm (69.04%), papillary histological type (95.24%), with location in one wolf, not multicenter, (61.90 %), lack of angiolymphatic invasion (67.85%), absence of invasion of the capsule (75%) without Hashimoto\'s thyroiditis (73.80%). In adjacent normal tissues it was observed that ER expression (77.77%) is greater than the PR expression (47.05%). In tumors observed the opposite, ERα (43.75%) and PR (47.5%) with a higher PR expression, these data were correlated with the clinical characteristics of tumors, such as gender, tumor size, age the diagnosis, capsular invasion, lymphatic invasion, Hashimoto\'s thyroiditis, tumor location, histological type and variants. |
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info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisImmunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancerAvaliaÃÃo imunohistoquÃmica da expressÃo de receptores estrogÃnicos αlfa e progesterona no carcinoma diferenciado de tireÃide2015-09-28Manoel Ricardo Alves Martins48034622320http://lattes.cnpq.br/3503117351197846Margarida Maria de Lima Pompeu11779420382Ana Rosa Pinto Quidute89941357404http://lattes.cnpq.br/0730748142072670Ana Karina de Melo Bezerra SodrÃ51430819391http://lattes.cnpq.br/866646965645247600725265302http://lattes.cnpq.br/4754243629545015Mayane Emanuela Melo Lopes MartinsUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em PatologiaUFCBRANATOMIA PATOLOGICA E PATOLOGIA CLINICAWith the use of sensitive imaging methods, there is an increase in thyroid nodules diagnosed. Even the CDT (differentiated thyroid cancer) being proportionately rare, its incidence is increasing, especially small tumors whose clinical outcome is uncertain. It is observed that in clinical practice most patients with CDT develops well when properly treated, mortality rates similar to the general population. On the other hand, a non-negligible percentage has relapses and some eventually not respond to conventional therapies, and died. It can be seen that with the need to identify markers that can predict the behavior of tumors, mainly due to the variable clinical disease progression. With these data, some researchers in search of these markers, are studying a possible relationship of hormonal and reproductive factors in the evolution of CDT. This study analyzes the immunoreactivity of α estrogen receptor (ERα) and progesterone receptor (PR), correlating it with clinical features in 80 female and male patients with papillary thyroid cancer (PDT) and follicular thyroid cancer (FDT ) with materials related to thyroidectomy pieces performed at the University Hospital Walter CantÃdio (HUWC) in the period from 2010 to 2014. There was a predominance of female patients (87.5%), older than or equal to 40 years (68.57%), average age 49.12, tumor size> 1 cm (69.04%), papillary histological type (95.24%), with location in one wolf, not multicenter, (61.90 %), lack of angiolymphatic invasion (67.85%), absence of invasion of the capsule (75%) without Hashimoto\'s thyroiditis (73.80%). In adjacent normal tissues it was observed that ER expression (77.77%) is greater than the PR expression (47.05%). In tumors observed the opposite, ERα (43.75%) and PR (47.5%) with a higher PR expression, these data were correlated with the clinical characteristics of tumors, such as gender, tumor size, age the diagnosis, capsular invasion, lymphatic invasion, Hashimoto\'s thyroiditis, tumor location, histological type and variants.Com o uso de mÃtodos sensÃveis de imagem, observa-se um aumento nos nÃdulos tireoidianos diagnosticados. Mesmo o CDT (cÃncer diferenciado de tireÃide) sendo proporcionalmente raro, sua incidÃncia vem aumentando, especialmente de tumores pequenos, cuja evoluÃÃo clÃnica à incerta. Observa-se na prÃtica clÃnica que a maioria dos pacientes com CDT evolui bem quando adequadamente tratada, com Ãndices de mortalidade similares à populaÃÃo geral. Por outro lado, um percentual nÃo desprezÃvel apresenta recidivas e alguns eventualmente nÃo respondem Ãs terapias convencionais, evoluindo para Ãbito. Percebe-se com isso a necessidade de identificaÃÃo de marcadores que possam predizer o comportamento dos tumores devido, sobretudo, à variabilidade na progressÃo clÃnica da doenÃa. Com esses dados, alguns pesquisadores, em busca desses marcadores, estÃo estudando uma possÃvel relaÃÃo de fatores hormonais e reprodutivos na evoluÃÃo do CDT. No presente estudo analisamos a imunoexpressÃo do receptor de estrogÃnio α (ERα) e receptor de progesterona (PR), correlacionando-a com caracterÃsticas clÃnicas, em 80 pacientes femininos e masculinos com cÃncer papilÃfero de tireÃide (PDT) e cÃncer folicular de tireÃide (FDT), utilizando material referente a peÃas de tireoidectomia realizadas no Hospital UniversitÃrio Walter CantÃdio (HUWC), no perÃodo de 2010 a 2014. Observou-se o predomÃnio de pacientes do sexo feminino (87,5%), com idade superior ou igual a 40 anos (68,57%), mÃdia de idade 49,12, tumor com dimensÃo >1cm (69,04%), tipo histolÃgico papilÃfero (95,24%), com localizaÃÃo em Ãnico lobo, nÃo multicÃntrico, (61,90%), ausÃncia de invasÃo angiolinfÃtica (67,85%), ausÃncia de invasÃo da cÃpsula (75%), sem Tireoidite de Hashimoto (73,80%). Em tecidos normais adjacentes observou-se que a expressÃo de RE (77,77%) à maior que a expressÃo de RP (47,05%). Em tumores observou-se o contrÃrio, ERα (43,75%) e PR (47,5%) sendo maior a expressÃo de RP, esses dados foram correlacionados com as caracterÃsticas clÃnicas dos tumores, como: sexo, tamanho do tumor, idade ao diagnÃstico, invasÃo capsular, invasÃo linfÃtica, tireoidite de Hashimoto, localizaÃÃo do tumor, tipo histolÃgico e variantes.Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgicohttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16565application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:30:01Zmail@mail.com - |
dc.title..fl_str_mv |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer |
dc.title.alternative.pt.fl_str_mv |
AvaliaÃÃo imunohistoquÃmica da expressÃo de receptores estrogÃnicos αlfa e progesterona no carcinoma diferenciado de tireÃide |
title |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer |
spellingShingle |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer Mayane Emanuela Melo Lopes Martins ANATOMIA PATOLOGICA E PATOLOGIA CLINICA |
title_short |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer |
title_full |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer |
title_fullStr |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer |
title_full_unstemmed |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer |
title_sort |
Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer |
author |
Mayane Emanuela Melo Lopes Martins |
author_facet |
Mayane Emanuela Melo Lopes Martins |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Manoel Ricardo Alves Martins |
dc.contributor.advisor1ID.fl_str_mv |
48034622320 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3503117351197846 |
dc.contributor.referee1.fl_str_mv |
Margarida Maria de Lima Pompeu |
dc.contributor.referee1ID.fl_str_mv |
11779420382 |
dc.contributor.referee2.fl_str_mv |
Ana Rosa Pinto Quidute |
dc.contributor.referee2ID.fl_str_mv |
89941357404 |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/0730748142072670 |
dc.contributor.referee3.fl_str_mv |
Ana Karina de Melo Bezerra Sodrà |
dc.contributor.referee3ID.fl_str_mv |
51430819391 |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/8666469656452476 |
dc.contributor.authorID.fl_str_mv |
00725265302 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4754243629545015 |
dc.contributor.author.fl_str_mv |
Mayane Emanuela Melo Lopes Martins |
contributor_str_mv |
Manoel Ricardo Alves Martins Margarida Maria de Lima Pompeu Ana Rosa Pinto Quidute Ana Karina de Melo Bezerra Sodrà |
dc.subject.cnpq.fl_str_mv |
ANATOMIA PATOLOGICA E PATOLOGIA CLINICA |
topic |
ANATOMIA PATOLOGICA E PATOLOGIA CLINICA |
dc.description.sponsorship.fl_txt_mv |
Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico |
dc.description.abstract.por.fl_txt_mv |
With the use of sensitive imaging methods, there is an increase in thyroid nodules diagnosed. Even the CDT (differentiated thyroid cancer) being proportionately rare, its incidence is increasing, especially small tumors whose clinical outcome is uncertain. It is observed that in clinical practice most patients with CDT develops well when properly treated, mortality rates similar to the general population. On the other hand, a non-negligible percentage has relapses and some eventually not respond to conventional therapies, and died. It can be seen that with the need to identify markers that can predict the behavior of tumors, mainly due to the variable clinical disease progression. With these data, some researchers in search of these markers, are studying a possible relationship of hormonal and reproductive factors in the evolution of CDT. This study analyzes the immunoreactivity of α estrogen receptor (ERα) and progesterone receptor (PR), correlating it with clinical features in 80 female and male patients with papillary thyroid cancer (PDT) and follicular thyroid cancer (FDT ) with materials related to thyroidectomy pieces performed at the University Hospital Walter CantÃdio (HUWC) in the period from 2010 to 2014. There was a predominance of female patients (87.5%), older than or equal to 40 years (68.57%), average age 49.12, tumor size> 1 cm (69.04%), papillary histological type (95.24%), with location in one wolf, not multicenter, (61.90 %), lack of angiolymphatic invasion (67.85%), absence of invasion of the capsule (75%) without Hashimoto\'s thyroiditis (73.80%). In adjacent normal tissues it was observed that ER expression (77.77%) is greater than the PR expression (47.05%). In tumors observed the opposite, ERα (43.75%) and PR (47.5%) with a higher PR expression, these data were correlated with the clinical characteristics of tumors, such as gender, tumor size, age the diagnosis, capsular invasion, lymphatic invasion, Hashimoto\'s thyroiditis, tumor location, histological type and variants. Com o uso de mÃtodos sensÃveis de imagem, observa-se um aumento nos nÃdulos tireoidianos diagnosticados. Mesmo o CDT (cÃncer diferenciado de tireÃide) sendo proporcionalmente raro, sua incidÃncia vem aumentando, especialmente de tumores pequenos, cuja evoluÃÃo clÃnica à incerta. Observa-se na prÃtica clÃnica que a maioria dos pacientes com CDT evolui bem quando adequadamente tratada, com Ãndices de mortalidade similares à populaÃÃo geral. Por outro lado, um percentual nÃo desprezÃvel apresenta recidivas e alguns eventualmente nÃo respondem Ãs terapias convencionais, evoluindo para Ãbito. Percebe-se com isso a necessidade de identificaÃÃo de marcadores que possam predizer o comportamento dos tumores devido, sobretudo, à variabilidade na progressÃo clÃnica da doenÃa. Com esses dados, alguns pesquisadores, em busca desses marcadores, estÃo estudando uma possÃvel relaÃÃo de fatores hormonais e reprodutivos na evoluÃÃo do CDT. No presente estudo analisamos a imunoexpressÃo do receptor de estrogÃnio α (ERα) e receptor de progesterona (PR), correlacionando-a com caracterÃsticas clÃnicas, em 80 pacientes femininos e masculinos com cÃncer papilÃfero de tireÃide (PDT) e cÃncer folicular de tireÃide (FDT), utilizando material referente a peÃas de tireoidectomia realizadas no Hospital UniversitÃrio Walter CantÃdio (HUWC), no perÃodo de 2010 a 2014. Observou-se o predomÃnio de pacientes do sexo feminino (87,5%), com idade superior ou igual a 40 anos (68,57%), mÃdia de idade 49,12, tumor com dimensÃo >1cm (69,04%), tipo histolÃgico papilÃfero (95,24%), com localizaÃÃo em Ãnico lobo, nÃo multicÃntrico, (61,90%), ausÃncia de invasÃo angiolinfÃtica (67,85%), ausÃncia de invasÃo da cÃpsula (75%), sem Tireoidite de Hashimoto (73,80%). Em tecidos normais adjacentes observou-se que a expressÃo de RE (77,77%) à maior que a expressÃo de RP (47,05%). Em tumores observou-se o contrÃrio, ERα (43,75%) e PR (47,5%) sendo maior a expressÃo de RP, esses dados foram correlacionados com as caracterÃsticas clÃnicas dos tumores, como: sexo, tamanho do tumor, idade ao diagnÃstico, invasÃo capsular, invasÃo linfÃtica, tireoidite de Hashimoto, localizaÃÃo do tumor, tipo histolÃgico e variantes. |
description |
With the use of sensitive imaging methods, there is an increase in thyroid nodules diagnosed. Even the CDT (differentiated thyroid cancer) being proportionately rare, its incidence is increasing, especially small tumors whose clinical outcome is uncertain. It is observed that in clinical practice most patients with CDT develops well when properly treated, mortality rates similar to the general population. On the other hand, a non-negligible percentage has relapses and some eventually not respond to conventional therapies, and died. It can be seen that with the need to identify markers that can predict the behavior of tumors, mainly due to the variable clinical disease progression. With these data, some researchers in search of these markers, are studying a possible relationship of hormonal and reproductive factors in the evolution of CDT. This study analyzes the immunoreactivity of α estrogen receptor (ERα) and progesterone receptor (PR), correlating it with clinical features in 80 female and male patients with papillary thyroid cancer (PDT) and follicular thyroid cancer (FDT ) with materials related to thyroidectomy pieces performed at the University Hospital Walter CantÃdio (HUWC) in the period from 2010 to 2014. There was a predominance of female patients (87.5%), older than or equal to 40 years (68.57%), average age 49.12, tumor size> 1 cm (69.04%), papillary histological type (95.24%), with location in one wolf, not multicenter, (61.90 %), lack of angiolymphatic invasion (67.85%), absence of invasion of the capsule (75%) without Hashimoto\'s thyroiditis (73.80%). In adjacent normal tissues it was observed that ER expression (77.77%) is greater than the PR expression (47.05%). In tumors observed the opposite, ERα (43.75%) and PR (47.5%) with a higher PR expression, these data were correlated with the clinical characteristics of tumors, such as gender, tumor size, age the diagnosis, capsular invasion, lymphatic invasion, Hashimoto\'s thyroiditis, tumor location, histological type and variants. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-09-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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publishedVersion |
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masterThesis |
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http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16565 |
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http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16565 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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dc.publisher.none.fl_str_mv |
Universidade Federal do Cearà |
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Programa de PÃs-GraduaÃÃo em Patologia |
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UFC |
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BR |
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Universidade Federal do Cearà |
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reponame:Biblioteca Digital de Teses e Dissertações da UFC instname:Universidade Federal do Ceará instacron:UFC |
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Biblioteca Digital de Teses e Dissertações da UFC |
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Biblioteca Digital de Teses e Dissertações da UFC |
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Universidade Federal do Ceará |
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UFC |
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