Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da Universidade Federal Fluminense (RIUFF) |
Texto Completo: | https://app.uff.br/riuff/handle/1/19448 |
Resumo: | Coronary angioplasty with stent implantation is a therapeutic method widely used in interventional cardiology for the treatment of coronary lesions. This technique often runs through puncture with the placement of a hemostatic introducer in the femoral artery. These sheaths must be removed after the procedure as soon as there is a normalization of blood crase, which can take several hours. This time can be shortened with the use of protamine, but its use is not widespread because of the potential increased risk of acute or subacute stent thrombosis. The objective of this study was to demonstrate the safety of the use of Protamine for the reversal of heparin anticoagulant effects after coronary angioplasty with stent implant, through absence of correlation of the drug use with the occurrence of acute or subacute stent thrombosis. 6,318 patients undergoing coronary angioplasty were evaluated in the Procordis hospital in the time span from June 1998 to January 2011. 5,290 patients fulfilled the criteria for inclusion and were divided into two groups: those who had received protamine after the intervention, consisting of 3,965 patients, and those who did not receive this drug, consisting of 1,325 patients. Univariate analysis was made to evaluate clinical parameters, angiographic data and the presence of stent thrombosis. The group that received no Protamine presented a greater percentage of diabetic patients (38.1% versus 27.4% p <0.0001), patients with cardiogenic shock (7.17% versus 1.11% p <0.0001), the presence of myocardial infarction with ST segment unbalance (22.5% versus 10.8% p <0.0001). However, the angiographic profile in the group that received Protamine featured greater occurrence of eccentric lesions (98.1% versus 94.1% p < 0.0001), more type C lesions (53.2% versus 40.5% p <0.0001), vessels with diameters smaller than 2.5 mm (23.2% versus 15.6% p< 0.0001), whereas the group without the protamine featured more injuries with presence of angiographic thrombi (25.3% versus 13.6% p<0.0001). Afterwards, there was a second division: subjects showing stent thrombosis, consisting of 26 patients, and those who did not have this complication, consisting of 5,270 patients. Univariate analysis for clinical and angiographic parameters and multivariate calculus, in order to identify independent predictors for stent thrombosis were performed and identified only acute infarction with ST segment unbalance as independent predictors. We found that the use of Protamine is safe after coronary intervention with stent implantation, as it was not associated with increased occurrence of acute and subacute thrombosis. |
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Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de StentAngioplastiaStentTrombose de stentProtaminaHeparinaIntrodutores femorais.CARDIOLOGIAMEDICINAAngioplastyStentStent thrombosisHeparinProtamineFemoral sheath.CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CARDIOLOGIACoronary angioplasty with stent implantation is a therapeutic method widely used in interventional cardiology for the treatment of coronary lesions. This technique often runs through puncture with the placement of a hemostatic introducer in the femoral artery. These sheaths must be removed after the procedure as soon as there is a normalization of blood crase, which can take several hours. This time can be shortened with the use of protamine, but its use is not widespread because of the potential increased risk of acute or subacute stent thrombosis. The objective of this study was to demonstrate the safety of the use of Protamine for the reversal of heparin anticoagulant effects after coronary angioplasty with stent implant, through absence of correlation of the drug use with the occurrence of acute or subacute stent thrombosis. 6,318 patients undergoing coronary angioplasty were evaluated in the Procordis hospital in the time span from June 1998 to January 2011. 5,290 patients fulfilled the criteria for inclusion and were divided into two groups: those who had received protamine after the intervention, consisting of 3,965 patients, and those who did not receive this drug, consisting of 1,325 patients. Univariate analysis was made to evaluate clinical parameters, angiographic data and the presence of stent thrombosis. The group that received no Protamine presented a greater percentage of diabetic patients (38.1% versus 27.4% p <0.0001), patients with cardiogenic shock (7.17% versus 1.11% p <0.0001), the presence of myocardial infarction with ST segment unbalance (22.5% versus 10.8% p <0.0001). However, the angiographic profile in the group that received Protamine featured greater occurrence of eccentric lesions (98.1% versus 94.1% p < 0.0001), more type C lesions (53.2% versus 40.5% p <0.0001), vessels with diameters smaller than 2.5 mm (23.2% versus 15.6% p< 0.0001), whereas the group without the protamine featured more injuries with presence of angiographic thrombi (25.3% versus 13.6% p<0.0001). Afterwards, there was a second division: subjects showing stent thrombosis, consisting of 26 patients, and those who did not have this complication, consisting of 5,270 patients. Univariate analysis for clinical and angiographic parameters and multivariate calculus, in order to identify independent predictors for stent thrombosis were performed and identified only acute infarction with ST segment unbalance as independent predictors. We found that the use of Protamine is safe after coronary intervention with stent implantation, as it was not associated with increased occurrence of acute and subacute thrombosis.A angioplastia coronária com implante de stent é um método terapêutico amplamente utilizado na cardiologia intervencionista para o tratamento de lesões coronárias. Frequentemente esta técnica é executada através de punção com colocação de introdutor hemostático na artéria femoral. Esses introdutores devem ser retirados após o procedimento tão logo haja normalização da crase sanguínea, o que pode levar várias horas. Este tempo pode ser abreviado com o uso de protamina, porém o seu uso não é amplamente difundido devido ao possível maior risco de trombose aguda ou subaguda de stent. O objetivo primário deste estudo foi analisar a segurança do uso da Protamina para a reversão dos efeitos anticoagulantes da Heparina, após a angioplastia coronária com implante de stent, através da ausência de correlação do uso da droga com a ocorrência de trombose aguda ou subaguda de stent e os objetivos secundários foram identificar os preditores de trombose de stent e demonstrar, de forma indireta, os benefícios da retirada precoce dos introdutores femorais. Foram avaliados 6318 pacientes submetidos à angioplastia coronária no hospital Procordis no período de Junho de 1998 a Janeiro de 2011. Preencheram os critérios de inclusão, 5290 pacientes os quais foram divididos primeiramente em dois grupos: os que receberam protamina após a intervenção com 3965 pacientes e os que não receberam esta droga com 1325 pacientes, sendo feita a análise univariável para parâmetros clínicos, angiográficos e quanto à presença de trombose de stent O grupo que não recebeu Protamina apresentou um percentual maior de pacientes diabéticos (38,1% versus 27,4% p<0,0001) pacientes com choque cardiogênico (7,17% versus 1,11% p<0,0001), presença de infarto agudo do miocárdio com supra desnível do segmento ST (22,5% versus 10,8% p<0,0001), porém o perfil angiográfico no grupo que recebeu Protamina apresentava maior ocorrência de lesões excêntricas (98,1% versus 94,1% p<0,0001), mais lesões do tipo C (53,2% versus 40,5% p<0,0001), vasos com diâmetros menores que 2,5mm (23,2% versus 15,6% p<0,0001) e o grupo sem a protamina que apresentava mais lesões com presença de trombos angiográficos (25,3% versus 13,6% p<0,0001). Depois, realizou-se uma segunda divisão: os que apresentaram trombose de stent com 26 pacientes e os que não apresentaram esta complicação com 5.270 pacientes. Foi feita a análise univariável para parâmetros clínicos e angiográficos e multivariável para identificar preditores independentes de trombose de stent. Apenas o quadro de infarto agudo com supradesnível do segmento ST foi identificado como preditor independente para trombose de stent. Concluímos que a Protamina é segura, após a intervenção coronária com implante de stent, por não estar associada à maior ocorrência de trombose aguda e subaguda e apenas o infarto agudo do miocárdio foi um preditor independente de trombose.Programa de Pós-graduação em CardiologiaCardiologiaPeixoto, Edison Carvalho SandovalCPF:95897498722http://lattes.cnpq.br/0546685623579590Romêo, Luiz José MartinsCPF:41795641122http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4706272Y6Atie, JacobCPF:79578292022http://lattes.cnpq.br/1887037599764127Reis, Paulo Eduardo OckeCPF:48282828822http://lattes.cnpq.br/0252127105290905Gonçalves, Bernardo Kremer Diniz2021-03-10T20:47:28Z2012-01-132021-03-10T20:47:28Z2011-11-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://app.uff.br/riuff/handle/1/19448porCC-BY-SAinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da Universidade Federal Fluminense (RIUFF)instname:Universidade Federal Fluminense (UFF)instacron:UFF2021-03-10T20:47:28Zoai:app.uff.br:1/19448Repositório InstitucionalPUBhttps://app.uff.br/oai/requestriuff@id.uff.bropendoar:21202024-08-19T10:58:34.191881Repositório Institucional da Universidade Federal Fluminense (RIUFF) - Universidade Federal Fluminense (UFF)false |
dc.title.none.fl_str_mv |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent |
title |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent |
spellingShingle |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent Gonçalves, Bernardo Kremer Diniz Angioplastia Stent Trombose de stent Protamina Heparina Introdutores femorais. CARDIOLOGIA MEDICINA Angioplasty Stent Stent thrombosis Heparin Protamine Femoral sheath. CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CARDIOLOGIA |
title_short |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent |
title_full |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent |
title_fullStr |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent |
title_full_unstemmed |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent |
title_sort |
Uso de protamina para retirada precoce dos introdutores femorais após angioplastia coronária com implante de Stent |
author |
Gonçalves, Bernardo Kremer Diniz |
author_facet |
Gonçalves, Bernardo Kremer Diniz |
author_role |
author |
dc.contributor.none.fl_str_mv |
Peixoto, Edison Carvalho Sandoval CPF:95897498722 http://lattes.cnpq.br/0546685623579590 Romêo, Luiz José Martins CPF:41795641122 http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4706272Y6 Atie, Jacob CPF:79578292022 http://lattes.cnpq.br/1887037599764127 Reis, Paulo Eduardo Ocke CPF:48282828822 http://lattes.cnpq.br/0252127105290905 |
dc.contributor.author.fl_str_mv |
Gonçalves, Bernardo Kremer Diniz |
dc.subject.por.fl_str_mv |
Angioplastia Stent Trombose de stent Protamina Heparina Introdutores femorais. CARDIOLOGIA MEDICINA Angioplasty Stent Stent thrombosis Heparin Protamine Femoral sheath. CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CARDIOLOGIA |
topic |
Angioplastia Stent Trombose de stent Protamina Heparina Introdutores femorais. CARDIOLOGIA MEDICINA Angioplasty Stent Stent thrombosis Heparin Protamine Femoral sheath. CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CARDIOLOGIA |
description |
Coronary angioplasty with stent implantation is a therapeutic method widely used in interventional cardiology for the treatment of coronary lesions. This technique often runs through puncture with the placement of a hemostatic introducer in the femoral artery. These sheaths must be removed after the procedure as soon as there is a normalization of blood crase, which can take several hours. This time can be shortened with the use of protamine, but its use is not widespread because of the potential increased risk of acute or subacute stent thrombosis. The objective of this study was to demonstrate the safety of the use of Protamine for the reversal of heparin anticoagulant effects after coronary angioplasty with stent implant, through absence of correlation of the drug use with the occurrence of acute or subacute stent thrombosis. 6,318 patients undergoing coronary angioplasty were evaluated in the Procordis hospital in the time span from June 1998 to January 2011. 5,290 patients fulfilled the criteria for inclusion and were divided into two groups: those who had received protamine after the intervention, consisting of 3,965 patients, and those who did not receive this drug, consisting of 1,325 patients. Univariate analysis was made to evaluate clinical parameters, angiographic data and the presence of stent thrombosis. The group that received no Protamine presented a greater percentage of diabetic patients (38.1% versus 27.4% p <0.0001), patients with cardiogenic shock (7.17% versus 1.11% p <0.0001), the presence of myocardial infarction with ST segment unbalance (22.5% versus 10.8% p <0.0001). However, the angiographic profile in the group that received Protamine featured greater occurrence of eccentric lesions (98.1% versus 94.1% p < 0.0001), more type C lesions (53.2% versus 40.5% p <0.0001), vessels with diameters smaller than 2.5 mm (23.2% versus 15.6% p< 0.0001), whereas the group without the protamine featured more injuries with presence of angiographic thrombi (25.3% versus 13.6% p<0.0001). Afterwards, there was a second division: subjects showing stent thrombosis, consisting of 26 patients, and those who did not have this complication, consisting of 5,270 patients. Univariate analysis for clinical and angiographic parameters and multivariate calculus, in order to identify independent predictors for stent thrombosis were performed and identified only acute infarction with ST segment unbalance as independent predictors. We found that the use of Protamine is safe after coronary intervention with stent implantation, as it was not associated with increased occurrence of acute and subacute thrombosis. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-11-28 2012-01-13 2021-03-10T20:47:28Z 2021-03-10T20:47:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://app.uff.br/riuff/handle/1/19448 |
url |
https://app.uff.br/riuff/handle/1/19448 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
CC-BY-SA info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
CC-BY-SA |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Programa de Pós-graduação em Cardiologia Cardiologia |
publisher.none.fl_str_mv |
Programa de Pós-graduação em Cardiologia Cardiologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal Fluminense (RIUFF) instname:Universidade Federal Fluminense (UFF) instacron:UFF |
instname_str |
Universidade Federal Fluminense (UFF) |
instacron_str |
UFF |
institution |
UFF |
reponame_str |
Repositório Institucional da Universidade Federal Fluminense (RIUFF) |
collection |
Repositório Institucional da Universidade Federal Fluminense (RIUFF) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal Fluminense (RIUFF) - Universidade Federal Fluminense (UFF) |
repository.mail.fl_str_mv |
riuff@id.uff.br |
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1811823624534884352 |