Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno

Detalhes bibliográficos
Autor(a) principal: Moraes, Aline Pereira
Data de Publicação: 2013
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/0013000008x60
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/3316
Resumo: The use of natural products and their synthetic derivatives has been a relevant strategy in the development of novel medicines. Phytochemical studies and synthesis of natural-product-based libraries are primordial in the search for therapeutic agents. Previous phytochemical studies of genus Psychotria (Rubiaceae) have resulted in the identification of polypyrrolidine indole and monoterpenoid indole alkaloids, which present a broad range of biological activities, such as antifungal and inhibition of monoamine oxidases (MAOs) A e B, that are related to neurodegenerative diseases. This study aims to evaluate the phytochemical composition of the aerial parts of Psychotria sp. collected in Brazilian Cerrado. Fractionation of the crude extract by column chromatography on silica gel and Sephadex led to isolation of three known indole alkaloids: bahienoside A, desoxycordifoline and desoxycordifolinic acid. Additionally, thiohydantoins and thioureas were synthesized from amino acids and R- (+)-limonene, in order to assess the cooperative effect of indole nucleus combined with terpene, thiourea and thiohydantoin units. Preliminary tests showed that desoxycordifoline, hydantoin (20) and thiohydantoin necrostatin-1 (14) inhibit the enzyme MAO-A higher than 80% at concentrations of 175 mM, 100 mM, 386 mM, respectively. Also, the polar extracts of the leaves of Psychotria sp. showed antioxidant activity with IC50 < 50 mg.mL-1 measured by DPPH free radical scavenging assay.
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spelling Oliveira , Cecília Maria Alves dehttp://lattes.cnpq.br/3152041311943092Oliveira, Cecília Maria Alves deFátima, Angelo deQueiroz Jùnior, Luiz Henrique Kenghttp://lattes.cnpq.br/0544729947116030Moraes, Aline Pereira2014-10-09T15:30:41Z2013-05-03MORAES, Aline Pereira. Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno. 2013. 169 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2013.http://repositorio.bc.ufg.br/tede/handle/tede/3316ark:/38995/0013000008x60The use of natural products and their synthetic derivatives has been a relevant strategy in the development of novel medicines. Phytochemical studies and synthesis of natural-product-based libraries are primordial in the search for therapeutic agents. Previous phytochemical studies of genus Psychotria (Rubiaceae) have resulted in the identification of polypyrrolidine indole and monoterpenoid indole alkaloids, which present a broad range of biological activities, such as antifungal and inhibition of monoamine oxidases (MAOs) A e B, that are related to neurodegenerative diseases. This study aims to evaluate the phytochemical composition of the aerial parts of Psychotria sp. collected in Brazilian Cerrado. Fractionation of the crude extract by column chromatography on silica gel and Sephadex led to isolation of three known indole alkaloids: bahienoside A, desoxycordifoline and desoxycordifolinic acid. Additionally, thiohydantoins and thioureas were synthesized from amino acids and R- (+)-limonene, in order to assess the cooperative effect of indole nucleus combined with terpene, thiourea and thiohydantoin units. Preliminary tests showed that desoxycordifoline, hydantoin (20) and thiohydantoin necrostatin-1 (14) inhibit the enzyme MAO-A higher than 80% at concentrations of 175 mM, 100 mM, 386 mM, respectively. Also, the polar extracts of the leaves of Psychotria sp. showed antioxidant activity with IC50 < 50 mg.mL-1 measured by DPPH free radical scavenging assay.O uso de produtos naturais e seus derivados sintéticos tem sido uma relevante estratégia no desenvolvimento de novos medicamentos. Estudos fitoquímicos e derivatização de produtos naturais são fundamentais na busca por protótipos de fármacos. Estudos fitoquímicos anteriores do gênero Psychotria (Rubiaceae) resultaram na identificação de alcaloides indólicos monoterpênicos e pirroloindólicos. Essas classes de compostos são associadas a um amplo espectro de atividades biológicas, tais como antifúngica e de inibição de enzimas monoaminoxidases A e B (MAOs) relacionadas a doenças neurodegenerativas. Assim, esse trabalho teve como objetivo realizar o estudo fitoquímico das partes aéreas de Psychotria sp., presente no cerrado goiano. O fracionamento do extrato bruto por cromatografia em coluna em sílica gel e Sephadex resultou no isolamento de três alcaloides indólicos conhecidos: bahienosida A, desoxicordifolina e ácido desoxicordifolínico. Neste trabalho, tiohidantoínas e tioureias derivadas do R-(+)-limoneno e de aminoácidos, tais como o triptofano, foram sintetizadas, com o intuito de avaliar o efeito cooperativo do núcleo indólico combinado com as unidades terpênica, tioureia e tiohidantoína na ação antifúngica e de inibição das enzimas MAOs. Testes preliminares mostraram que desoxicordifolina, hidantoína (20) e tiohidantoína necrostatina-1 (14) inibem a enzima MAO-A acima de 80% nas concentrações de 175 μM, 100 μM, 386 μM, respectivamente. Ainda, os extratos polares das folhas de Psychotria sp mostraram atividade antioxidante com CI50 < 50 mg.mL-1 pelo método de captura dos radicais DPPH.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2014-10-09T15:01:20Z No. of bitstreams: 2 Dissertação - Aline Pereira Moraes - 2013.pdf: 2375025 bytes, checksum: edebdd82c526094db969a19e855e1017 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2014-10-09T15:30:41Z (GMT) No. of bitstreams: 2 Dissertação - Aline Pereira Moraes - 2013.pdf: 2375025 bytes, checksum: edebdd82c526094db969a19e855e1017 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2014-10-09T15:30:41Z (GMT). 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dc.title.por.fl_str_mv Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
dc.title.alternative.eng.fl_str_mv Indole alkaloids from the aerial parts of psychotria sp. (rubiaceae) and synthesis of thioureas and thiohydantoins derived from amino acids and r-(+)-limonene
title Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
spellingShingle Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
Moraes, Aline Pereira
Psychotria
Alcaloides indólicos
Tioureias
Tiohidantoínas
Psychotria
Indole alkaloids
Thioureas
Thiohydantoins
QUIMICA::QUIMICA INORGANICA
title_short Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
title_full Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
title_fullStr Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
title_full_unstemmed Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
title_sort Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno
author Moraes, Aline Pereira
author_facet Moraes, Aline Pereira
author_role author
dc.contributor.advisor1.fl_str_mv Oliveira , Cecília Maria Alves de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3152041311943092
dc.contributor.referee1.fl_str_mv Oliveira, Cecília Maria Alves de
dc.contributor.referee2.fl_str_mv Fátima, Angelo de
dc.contributor.referee3.fl_str_mv Queiroz Jùnior, Luiz Henrique Keng
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0544729947116030
dc.contributor.author.fl_str_mv Moraes, Aline Pereira
contributor_str_mv Oliveira , Cecília Maria Alves de
Oliveira, Cecília Maria Alves de
Fátima, Angelo de
Queiroz Jùnior, Luiz Henrique Keng
dc.subject.por.fl_str_mv Psychotria
Alcaloides indólicos
Tioureias
Tiohidantoínas
topic Psychotria
Alcaloides indólicos
Tioureias
Tiohidantoínas
Psychotria
Indole alkaloids
Thioureas
Thiohydantoins
QUIMICA::QUIMICA INORGANICA
dc.subject.eng.fl_str_mv Psychotria
Indole alkaloids
Thioureas
Thiohydantoins
dc.subject.cnpq.fl_str_mv QUIMICA::QUIMICA INORGANICA
description The use of natural products and their synthetic derivatives has been a relevant strategy in the development of novel medicines. Phytochemical studies and synthesis of natural-product-based libraries are primordial in the search for therapeutic agents. Previous phytochemical studies of genus Psychotria (Rubiaceae) have resulted in the identification of polypyrrolidine indole and monoterpenoid indole alkaloids, which present a broad range of biological activities, such as antifungal and inhibition of monoamine oxidases (MAOs) A e B, that are related to neurodegenerative diseases. This study aims to evaluate the phytochemical composition of the aerial parts of Psychotria sp. collected in Brazilian Cerrado. Fractionation of the crude extract by column chromatography on silica gel and Sephadex led to isolation of three known indole alkaloids: bahienoside A, desoxycordifoline and desoxycordifolinic acid. Additionally, thiohydantoins and thioureas were synthesized from amino acids and R- (+)-limonene, in order to assess the cooperative effect of indole nucleus combined with terpene, thiourea and thiohydantoin units. Preliminary tests showed that desoxycordifoline, hydantoin (20) and thiohydantoin necrostatin-1 (14) inhibit the enzyme MAO-A higher than 80% at concentrations of 175 mM, 100 mM, 386 mM, respectively. Also, the polar extracts of the leaves of Psychotria sp. showed antioxidant activity with IC50 < 50 mg.mL-1 measured by DPPH free radical scavenging assay.
publishDate 2013
dc.date.issued.fl_str_mv 2013-05-03
dc.date.accessioned.fl_str_mv 2014-10-09T15:30:41Z
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dc.identifier.citation.fl_str_mv MORAES, Aline Pereira. Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno. 2013. 169 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2013.
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dc.identifier.dark.fl_str_mv ark:/38995/0013000008x60
identifier_str_mv MORAES, Aline Pereira. Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno. 2013. 169 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2013.
ark:/38995/0013000008x60
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publisher.none.fl_str_mv Universidade Federal de Goiás
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repository.mail.fl_str_mv tasesdissertacoes.bc@ufg.br
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