Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFLA |
| Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/32518 |
Resumo: | In this study, an in vivo anti-inflammatory assay was conducted on Psychotria stenocalyx ethanol extract of leaves, evaluating this effect on cell migration and exudate formation in a murine carrageenan-induced model of pleurisy. The extract showed the optimum dose, at 400 mg/kg, inhibiting cellular and vascular parameters: total leucocytes due to polymorphonuclear migration and exudate formation (p < 0.01). A phytochemical study was conducted using the hyphenated techniques HPLC-DAD-SPE/NMR and HPLC-DAD-ESI-TOF-HRMS, in which seven monoterpene indole alkaloids were identified: lyaloside 1, (E)-O-(6&′)-cinnamoyl-4”-hydroxy-3”,5”-dimethoxy-lyaloside 2, strictosamide 3, pauridianthoside 4, vallesiachotamine lactone 5, E-vallesiachotamine 6 and Z-vallesiachotamine 7, in the alkaloid fraction, obtained by an acid-base extraction on P. stenocalyx crude extract. This is the first study developed with this species. |
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Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae)Psychotria stenocalyxAntiinflammatoryMonoterpene indole alkaloidsAntiinflamatórioAlcalóides indólicos monoterpénicosIn this study, an in vivo anti-inflammatory assay was conducted on Psychotria stenocalyx ethanol extract of leaves, evaluating this effect on cell migration and exudate formation in a murine carrageenan-induced model of pleurisy. The extract showed the optimum dose, at 400 mg/kg, inhibiting cellular and vascular parameters: total leucocytes due to polymorphonuclear migration and exudate formation (p < 0.01). A phytochemical study was conducted using the hyphenated techniques HPLC-DAD-SPE/NMR and HPLC-DAD-ESI-TOF-HRMS, in which seven monoterpene indole alkaloids were identified: lyaloside 1, (E)-O-(6&′)-cinnamoyl-4”-hydroxy-3”,5”-dimethoxy-lyaloside 2, strictosamide 3, pauridianthoside 4, vallesiachotamine lactone 5, E-vallesiachotamine 6 and Z-vallesiachotamine 7, in the alkaloid fraction, obtained by an acid-base extraction on P. stenocalyx crude extract. This is the first study developed with this species.ScopeMed2019-01-25T10:20:28Z2019-01-25T10:20:28Z2017-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfQUEIROZ, G. S. et al. Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae). Journal of Applied Pharmaceutical Science, [S. l.], v. 7, n. 4, p. 168-173, Apr. 2017.http://repositorio.ufla.br/jspui/handle/1/32518Journal of Applied Pharmaceutical Sciencereponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessQueiroz, Gustavo SilvaLuz, Ana Beatriz GobboNascimento, Marcus Vinícius Pereira dos SantosThomasi, Sergio ScherrerFerreira, Antonio GilbertoDalmarco, Eduardo MonguilhottBrighente, Ines Maria Costaeng2019-01-25T10:20:28Zoai:localhost:1/32518Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2019-01-25T10:20:28Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
| dc.title.none.fl_str_mv |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| title |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| spellingShingle |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) Queiroz, Gustavo Silva Psychotria stenocalyx Antiinflammatory Monoterpene indole alkaloids Antiinflamatório Alcalóides indólicos monoterpénicos |
| title_short |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| title_full |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| title_fullStr |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| title_full_unstemmed |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| title_sort |
Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| author |
Queiroz, Gustavo Silva |
| author_facet |
Queiroz, Gustavo Silva Luz, Ana Beatriz Gobbo Nascimento, Marcus Vinícius Pereira dos Santos Thomasi, Sergio Scherrer Ferreira, Antonio Gilberto Dalmarco, Eduardo Monguilhott Brighente, Ines Maria Costa |
| author_role |
author |
| author2 |
Luz, Ana Beatriz Gobbo Nascimento, Marcus Vinícius Pereira dos Santos Thomasi, Sergio Scherrer Ferreira, Antonio Gilberto Dalmarco, Eduardo Monguilhott Brighente, Ines Maria Costa |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Queiroz, Gustavo Silva Luz, Ana Beatriz Gobbo Nascimento, Marcus Vinícius Pereira dos Santos Thomasi, Sergio Scherrer Ferreira, Antonio Gilberto Dalmarco, Eduardo Monguilhott Brighente, Ines Maria Costa |
| dc.subject.por.fl_str_mv |
Psychotria stenocalyx Antiinflammatory Monoterpene indole alkaloids Antiinflamatório Alcalóides indólicos monoterpénicos |
| topic |
Psychotria stenocalyx Antiinflammatory Monoterpene indole alkaloids Antiinflamatório Alcalóides indólicos monoterpénicos |
| description |
In this study, an in vivo anti-inflammatory assay was conducted on Psychotria stenocalyx ethanol extract of leaves, evaluating this effect on cell migration and exudate formation in a murine carrageenan-induced model of pleurisy. The extract showed the optimum dose, at 400 mg/kg, inhibiting cellular and vascular parameters: total leucocytes due to polymorphonuclear migration and exudate formation (p < 0.01). A phytochemical study was conducted using the hyphenated techniques HPLC-DAD-SPE/NMR and HPLC-DAD-ESI-TOF-HRMS, in which seven monoterpene indole alkaloids were identified: lyaloside 1, (E)-O-(6&′)-cinnamoyl-4”-hydroxy-3”,5”-dimethoxy-lyaloside 2, strictosamide 3, pauridianthoside 4, vallesiachotamine lactone 5, E-vallesiachotamine 6 and Z-vallesiachotamine 7, in the alkaloid fraction, obtained by an acid-base extraction on P. stenocalyx crude extract. This is the first study developed with this species. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-04 2019-01-25T10:20:28Z 2019-01-25T10:20:28Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
QUEIROZ, G. S. et al. Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae). Journal of Applied Pharmaceutical Science, [S. l.], v. 7, n. 4, p. 168-173, Apr. 2017. http://repositorio.ufla.br/jspui/handle/1/32518 |
| identifier_str_mv |
QUEIROZ, G. S. et al. Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae). Journal of Applied Pharmaceutical Science, [S. l.], v. 7, n. 4, p. 168-173, Apr. 2017. |
| url |
http://repositorio.ufla.br/jspui/handle/1/32518 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
ScopeMed |
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ScopeMed |
| dc.source.none.fl_str_mv |
Journal of Applied Pharmaceutical Science reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
| instname_str |
Universidade Federal de Lavras (UFLA) |
| instacron_str |
UFLA |
| institution |
UFLA |
| reponame_str |
Repositório Institucional da UFLA |
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Repositório Institucional da UFLA |
| repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
| repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
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1815439120171794432 |