Efeito do extrato líquido concentrado obtido dos resíduos agroindustriais dos frutos de Myrciaria cauliflora sobre parâmetros cardiometabólicos de ratos Wistar submetidos ao modelo de obesidade induzida por glutamato monossódico

• Autor(a) principal: Teófilo , Monatha Nayara Guimarães T
• Data de Publicação: 2020
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/10528
• topic: Extrato; Jabuticaba; Obesidade; Núcleo arqueado; Metabolismo; Extract; Obesity; Arcuate nucleus; Metabolism; CIENCIAS BIOLOGICAS::FISIOLOGIA

Obesity is a multifactorial disease that develops from an imbalance in the energy balance (EB). The lesion in the arcuate nucleus of the hypothalamus in rodents causes an imbalance in EB, biochemical and hormonal resulting in excess body fat storage in the body. The concentrated liquid extract of the residue of the fruit of the jabuticaba - Myrciaria cauliflora (ECJ) has become promising in the prevention/ treatment of chronic diseases, such as obesity, due to its bioactive compounds and antioxidant properties. The purpose of this work was to analyze the effects of ECJ (3%) on body mass, blood pressure, hematological and biochemical parameters in obese rats with monosodium glutamate (MSG). In the first days of life, the rats received subcutaneous injections in the posterior cervical region of MSG (4 mg/g) and control rats injected with isotonic saline (0.9%). After the weaning period (21 days), the animals were distributed in 4 experimental groups, treated or not for 60 days with the ECJ (3%) by gavage, group 1: control (CT); group 2: control treated with the extract (CT+E); group 3: monosodium glutamate (MSG); group 4: monosodium glutamate treated with the extract (MSG+E). In our study, rats that received injections of MSG with or without ECJ (3%) had: lower body weight gain and nasal/anal length, higher Lee index, and fat weight: retroperitoneal, inguinal and epididymal, lower cardiac index, lower liver and kidney weight, and lymphocytopenia. The rats that received only MSG showed an increase in mean blood pressure (MAP), increased levels of triglycerides (TG), and very-low-density lipoprotein (VLDL), leukopenia, the relative increase in monocytes, eosinophils and basophils. The MSG+E group demonstrated values of MAP, TG, VLDL, and leukocytes similar to those of animals CT+E and a lower level of low-density lipoprotein (LDL). There were no significant histological differences in cardiac tissue, total cholesterol, high-density lipoprotein, and in levels of tumor necrosis factor-alpha, interleukin 6, interleukin 4 and interleukin 10, in animals. From this, we concluded that the MSG was effective in inducing the obesity model and that the treatment with ECJ (3%) for 60 days demonstrated a beneficial protective action through PAM, TG, VLDL, and LDL altered by obesity.