Poliglecaprone na reparação intestinal e muscular de coelhos (Oryctolagus cuniculus)

• Autor(a) principal: Ávila Filho, Saulo Humberto de
• Data de Publicação: 2017
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/7094
• topic: Biomaterial; Enterotomia; Histopatologia; Laparotomia; Termografia; Biomaterial; Enterotomy; Histopathology; Laparatomy; Thermography; MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL

Currently chitosan, biomaterial has been widely used, and its derivative has characteristics that can be absorbed by hydrolysis, are made by a monofilament and induce a discrete tissue response. Despite presenting promising results, it is still little known by the scientific environment and little commercially availability. The aim of this study was to compare the influence of chitosan and polyglecaprone sutures on tissue repair after cecorraphy and midline laparatomy closure rabbits (Oryctolagus cuniculus). 42 animals were allocated in two large groups, one of which was submitted to cecorraphy and midline laparotomy closure with chitosan suture, and other one with polyglecaprone. The postoperative complications were evaluated macroscopically and the tissue reactions microscopically on the 5th, 15th and 25th postoperative days. They were also, evaluated daily by the use of thermographic camera until the 15th day and, when possible, on the 25th day. After thermographic evaluation, a statistical difference was observed, obtaining p = 0.0003 between the Chitosan and Polyglecaprone groups. Regarding the macroscopic evaluation, a statistical difference in the incidence of complications between the groups was not observed. By the histological method, muscle healing differed between the groups regarding only the granulation tissue intensity (p = 0.041) and fibrosis (p = 0.030) on the 15th postoperative day. The intestinal repair evaluation differed only in the intensity of polymorphonuclear cells presence on the 15th postoperative day (p = 0.041). In conclusion, chitosan and poliglecaprone sutures were similarly effective in guaranteeing the healing of the cecum and rectus abdominis muscle after cecorraphy and midline laparotomy closure after the 25-day postoperative period.