Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4834 |
Resumo: | The human adenoviruses (HAdV) infect people of all ages worldwide, causing a wide range of clinical syndromes, depending on the viral type. In immunocompromised hosts, as transplanted patients, HAdV infection can result in a bad prognosis. Some aspects of viral pathogenesis, such as the association between viremia and/or viral load with disseminated disease and the optimal moment to start the therapy, are still not well established in adult patients that have undergone allogeneic hematopoietic stem cell transplantation (ASCT). Therefore, the main objective of this study was to monitor ASCT recipients for HAdV occurrence, and also correlate viral positivity, viral load and molecular variant with clinical symptoms and patients’ prognosis. For this, stool and serum from 21 patients were monitored in a 2 years period (from October/2012 to October/2014). Serum and fecal samples were screened by Nested-PCR, using primers targeting a partial region of the hexon gene (143bp). Fecal samples were further screened by a commercial enzyme immunoassay (EIA). In total, 57% of the patients had at least one positive sample (serum or stool) for HAdV. Patients presented high viral load (varying from 7,7x103 to 2x108 copies/mL), with a higher viral load in stool when compared to serum. Positive samples were submitted to genomic sequencing, revealing the occurrence of HAdV from C, D and F species. The main clinical symptom presented by infected patients was diarrhea, and graft-versus-host disease was the main intercurrence; however it was not possible to directly associate viral positivity to cause of death. We hope to contribute for a better understanding of the HAdV infection pattern in patients submitted to ASCT. Our data highlights the importance of the inclusion of HAdV testing in the routine laboratory exams of this group of patients. |
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Souza, Menira Borges de Lima Dias ehttp://lattes.cnpq.br/0054562567103606Souza, Menira Borges de Lima Dias eLoyola, Patricia Resende Alo NagibCosta, Paulo Sérgio Sucasas dahttp://lattes.cnpq.br/2936658105441688Santos, Hugo César Pereira2015-10-29T11:20:29Z2015-03-19SANTOS, H. C. P. Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas. 2015. 76 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/4834The human adenoviruses (HAdV) infect people of all ages worldwide, causing a wide range of clinical syndromes, depending on the viral type. In immunocompromised hosts, as transplanted patients, HAdV infection can result in a bad prognosis. Some aspects of viral pathogenesis, such as the association between viremia and/or viral load with disseminated disease and the optimal moment to start the therapy, are still not well established in adult patients that have undergone allogeneic hematopoietic stem cell transplantation (ASCT). Therefore, the main objective of this study was to monitor ASCT recipients for HAdV occurrence, and also correlate viral positivity, viral load and molecular variant with clinical symptoms and patients’ prognosis. For this, stool and serum from 21 patients were monitored in a 2 years period (from October/2012 to October/2014). Serum and fecal samples were screened by Nested-PCR, using primers targeting a partial region of the hexon gene (143bp). Fecal samples were further screened by a commercial enzyme immunoassay (EIA). In total, 57% of the patients had at least one positive sample (serum or stool) for HAdV. Patients presented high viral load (varying from 7,7x103 to 2x108 copies/mL), with a higher viral load in stool when compared to serum. Positive samples were submitted to genomic sequencing, revealing the occurrence of HAdV from C, D and F species. The main clinical symptom presented by infected patients was diarrhea, and graft-versus-host disease was the main intercurrence; however it was not possible to directly associate viral positivity to cause of death. We hope to contribute for a better understanding of the HAdV infection pattern in patients submitted to ASCT. Our data highlights the importance of the inclusion of HAdV testing in the routine laboratory exams of this group of patients.Os adenovírus humanos (HAdV) podem infectar pessoas de todas as idades, causando uma ampla gama de quadros clínicos. Em pacientes imunocomprometidos, como os indivíduos que receberam transplante, a infecção por esses vírus pode resultar em pior prognóstico para o paciente. Determinados aspectos da patogenia viral, como a associação entre viremia e/ou carga viral com a doença disseminada, bem como o melhor momento para o início da terapia, não estão ainda bem esclarecidos em pacientes que foram submetidos ao transplante de células progenitoras hematopoiéticas (TACPH), principalmente em indivíduos adultos. Dessa forma, o principal objetivo deste estudo foi realizar o monitoramento da infecção por HAdV e a caracterização molecular das variantes virais em pacientes submetidos ao TACPH, bem como determinar a carga viral e correlacionar a infecção com o quadro clínico e prognóstico dos pacientes. Foram analisadas amostras de soro e fezes de 21 pacientes submetidos ao TACPH no período de dois anos (de outubro/2012 a outubro/2014). As amostras de fezes foram triadas por ensaio imunoenzimático e por Nested-PCR, enquanto as amostras de soro foram triadas somente por Nested-PCR de uma região parcial do gene hexon (produto esperado de 143 pb). Foram detectadas amostras positivas de soro e/ou fezes de 57% dos pacientes. De forma geral, os pacientes do presente estudo apresentaram elevadas cargas virais (variando de 7,7x103 à 2x108 CG/mL), que foram mais elevadas nas fezes. As amostras positivas foram submetidas ao sequenciamento genômico e resultados revelaram a ocorrência de adenovírus das espécies C, D e F. O principal quadro clínico apresentado pelos pacientes foi a diarreia e a principal intercorrência observada, a doença do enxerto contra o hospedeiro (DECH). Dez pacientes foram a óbito durante o período de estudo, entretanto, não foi possível associar a infecção por HAdV diretamente à causa mortis. Esperamos que os dados obtidos possam auxiliar no melhor entendimento do padrão da infecção dos HAdVs em pacientes submetidos ao TACPH, de forma a contribuir para que a pesquisa de adenovírus seja incluída na rotina de exames desses pacientes.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-29T11:10:52Z No. of bitstreams: 2 Dissertação - Hugo César Pereira Santos - 2015.pdf: 3535564 bytes, checksum: 4fc7d88b1da6008bc42c01f46e4f8d7a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-29T11:20:29Z (GMT) No. of bitstreams: 2 Dissertação - Hugo César Pereira Santos - 2015.pdf: 3535564 bytes, checksum: 4fc7d88b1da6008bc42c01f46e4f8d7a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-10-29T11:20:29Z (GMT). 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dc.title.por.fl_str_mv |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas |
dc.title.alternative.eng.fl_str_mv |
Monitoring and molecular characterization of human adenovirus in samples from patients undergone allogeneic stem cell transplantation |
title |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas |
spellingShingle |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas Santos, Hugo César Pereira Adenovírus humanos Monitoramento Transplante alogênico de células progenitoras hematopoiéticas Viremia Bone marrow transplant HAdV monitoring Human adenovirus Viremia CIENCIAS BIOLOGICAS::PARASITOLOGIA |
title_short |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas |
title_full |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas |
title_fullStr |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas |
title_full_unstemmed |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas |
title_sort |
Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas |
author |
Santos, Hugo César Pereira |
author_facet |
Santos, Hugo César Pereira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Souza, Menira Borges de Lima Dias e |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0054562567103606 |
dc.contributor.referee1.fl_str_mv |
Souza, Menira Borges de Lima Dias e |
dc.contributor.referee2.fl_str_mv |
Loyola, Patricia Resende Alo Nagib |
dc.contributor.referee3.fl_str_mv |
Costa, Paulo Sérgio Sucasas da |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2936658105441688 |
dc.contributor.author.fl_str_mv |
Santos, Hugo César Pereira |
contributor_str_mv |
Souza, Menira Borges de Lima Dias e Souza, Menira Borges de Lima Dias e Loyola, Patricia Resende Alo Nagib Costa, Paulo Sérgio Sucasas da |
dc.subject.por.fl_str_mv |
Adenovírus humanos Monitoramento Transplante alogênico de células progenitoras hematopoiéticas Viremia |
topic |
Adenovírus humanos Monitoramento Transplante alogênico de células progenitoras hematopoiéticas Viremia Bone marrow transplant HAdV monitoring Human adenovirus Viremia CIENCIAS BIOLOGICAS::PARASITOLOGIA |
dc.subject.eng.fl_str_mv |
Bone marrow transplant HAdV monitoring Human adenovirus Viremia |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::PARASITOLOGIA |
description |
The human adenoviruses (HAdV) infect people of all ages worldwide, causing a wide range of clinical syndromes, depending on the viral type. In immunocompromised hosts, as transplanted patients, HAdV infection can result in a bad prognosis. Some aspects of viral pathogenesis, such as the association between viremia and/or viral load with disseminated disease and the optimal moment to start the therapy, are still not well established in adult patients that have undergone allogeneic hematopoietic stem cell transplantation (ASCT). Therefore, the main objective of this study was to monitor ASCT recipients for HAdV occurrence, and also correlate viral positivity, viral load and molecular variant with clinical symptoms and patients’ prognosis. For this, stool and serum from 21 patients were monitored in a 2 years period (from October/2012 to October/2014). Serum and fecal samples were screened by Nested-PCR, using primers targeting a partial region of the hexon gene (143bp). Fecal samples were further screened by a commercial enzyme immunoassay (EIA). In total, 57% of the patients had at least one positive sample (serum or stool) for HAdV. Patients presented high viral load (varying from 7,7x103 to 2x108 copies/mL), with a higher viral load in stool when compared to serum. Positive samples were submitted to genomic sequencing, revealing the occurrence of HAdV from C, D and F species. The main clinical symptom presented by infected patients was diarrhea, and graft-versus-host disease was the main intercurrence; however it was not possible to directly associate viral positivity to cause of death. We hope to contribute for a better understanding of the HAdV infection pattern in patients submitted to ASCT. Our data highlights the importance of the inclusion of HAdV testing in the routine laboratory exams of this group of patients. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-10-29T11:20:29Z |
dc.date.issued.fl_str_mv |
2015-03-19 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, H. C. P. Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas. 2015. 76 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4834 |
identifier_str_mv |
SANTOS, H. C. P. Monitoramento e caracterização molecular de adenovírus humanos em amostras provenientes de pacientes submetidos ao transplante de células progenitoras hematopoiéticas. 2015. 76 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2015. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4834 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6367159433410056917 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
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dc.relation.cnpq.fl_str_mv |
-4544576747271574306 |
dc.relation.sponsorship.fl_str_mv |
-961409807440757778 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Biologia das Interações PH (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
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UFG |
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UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/08bdfde8-7e06-4f71-929f-5b74833fd2a1/download http://repositorio.bc.ufg.br/tede/bitstreams/940407a5-819f-4467-9803-813630621f0e/download http://repositorio.bc.ufg.br/tede/bitstreams/d7fa103b-66cb-4dcd-876b-66a7882e49d5/download http://repositorio.bc.ufg.br/tede/bitstreams/e3633813-de30-44c9-88dd-506ce7ac9cce/download http://repositorio.bc.ufg.br/tede/bitstreams/f5891bc3-8e99-45a4-bf99-f6613ea6cbeb/download http://repositorio.bc.ufg.br/tede/bitstreams/ced5355d-d652-4fa4-8809-137317c48c78/download http://repositorio.bc.ufg.br/tede/bitstreams/637b1290-58c3-4452-a52a-29f41d8d67af/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f 683d9883b2ad62ac3b8bafc566b2e600 9da0b6dfac957114c6a7714714b86306 4fc7d88b1da6008bc42c01f46e4f8d7a 73fe99482626d47043423a0dbc6f4fb1 9b3853cd1051ef87f2eef14558f43ede |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044370993152000 |