Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
dARK ID: | ark:/38995/0013000003k97 |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4342 |
Resumo: | The vertical transmission of infection from mother to child, and may increase morbidity and mortality of both mother and child, when not diagnosed and by suitably dealest, causing a serious public health problem. This study aimed to estimate the prevalence of antibodies to toxoplasmosis, rubella, cytomegalovirus, hepatitis B, syphilis and HIV among pregnant women in Caxias, Maranhão, Brazil and identify the main factors associated with seropositivity for Toxoplasma gondii infection in pregnant women attending two referral centers Caxias, MA. Descriptive, observational, cross-sectional study of 561 pregnant women who received prenatal care at two clinics reference to prenatal high risk in the period July 2011 to December 2012, the outpatient clinics of Maternity Carmosina Coutinho (MCC) and the Specialized Center for Maternal and Child Care (CEAMI). Serological tests for toxoplasmosis, rubella, cytomegalovirus, hepatitis B were performed by a laboratory conveniado to the municipality by the same trained technician, and for syphilis and HIV were performed in the Counseling and Testing Center (ATC) in the city laboratory. And a small sample of whole blood from five pregnant IGM reagent for Toxoplasma gondii and their respective newborns was processed at the Institute of Tropical Pathology and Public Health in the Department of Parasitology UFG for performing Polymerase Chain Reaction (PCR). Statistical analysis was performed using SPSS version 20.0 Windows, using the chi-square tests of association and Odds Ratio (95%CI), considering a significance level of 5%. It was found to be positive for HIV was 0.4%, 2.0% syphilis, rubella and cytomegalovirus IgG reactivity were 93.6% and 87.8% respectively without reactive IgM, HBsAg was negative for all pregnant women in the sample tested. Regarding toxoplasmosis in 437 (77%), 124 susceptibility (22.1%) and 5 (0.9%) women with active infection. Found no significant association between toxoplasmosis susceptibility and age, location, income, education, sewerage, number of pregnancies and gestational age. Variables with significant association (p≤0.05) were seropositive pregnant women who are multiparous (p=0.036), living with dogs stuck at home (p=0.001), and consumption of raw kibbeh (p=0.036). The frequency of seropositivity of these infectious diseases of vertical transmission in pregnant women seen at antenatal care in the city of Caxias-MA is considered high, but are similar to those described in other regions of Brazil. Pregnant women who are multiparous who perform consumption of raw kibbeh and live with dogs that do not wobble on the street, had more chance of becoming infected with Toxoplasma gondii, thus guidance on primary prevention measures and quarterly serological monitoring should be strengthened these infections of pregnant women, since it is important to identify and/or prevent congenital infection measured. |
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Castro, Ana Maria dehttp://lattes.cnpq.br/9232309971000621Castro, Ana Maria deVinaud, Marina ClareAraújo, Telma Maria Evangelista deCampelo, ViriatoPinheiro, Valéria Cristina Soareshttp://lattes.cnpq.br/5718882034193418Câmara, Joseneide Teixeira2015-03-24T17:27:34Z2014-05-30CÂMARA, Joseneide Teixeira. Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão. 2014. 168 f. Tese (Doutorado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2014.http://repositorio.bc.ufg.br/tede/handle/tede/4342ark:/38995/0013000003k97The vertical transmission of infection from mother to child, and may increase morbidity and mortality of both mother and child, when not diagnosed and by suitably dealest, causing a serious public health problem. This study aimed to estimate the prevalence of antibodies to toxoplasmosis, rubella, cytomegalovirus, hepatitis B, syphilis and HIV among pregnant women in Caxias, Maranhão, Brazil and identify the main factors associated with seropositivity for Toxoplasma gondii infection in pregnant women attending two referral centers Caxias, MA. Descriptive, observational, cross-sectional study of 561 pregnant women who received prenatal care at two clinics reference to prenatal high risk in the period July 2011 to December 2012, the outpatient clinics of Maternity Carmosina Coutinho (MCC) and the Specialized Center for Maternal and Child Care (CEAMI). Serological tests for toxoplasmosis, rubella, cytomegalovirus, hepatitis B were performed by a laboratory conveniado to the municipality by the same trained technician, and for syphilis and HIV were performed in the Counseling and Testing Center (ATC) in the city laboratory. And a small sample of whole blood from five pregnant IGM reagent for Toxoplasma gondii and their respective newborns was processed at the Institute of Tropical Pathology and Public Health in the Department of Parasitology UFG for performing Polymerase Chain Reaction (PCR). Statistical analysis was performed using SPSS version 20.0 Windows, using the chi-square tests of association and Odds Ratio (95%CI), considering a significance level of 5%. It was found to be positive for HIV was 0.4%, 2.0% syphilis, rubella and cytomegalovirus IgG reactivity were 93.6% and 87.8% respectively without reactive IgM, HBsAg was negative for all pregnant women in the sample tested. Regarding toxoplasmosis in 437 (77%), 124 susceptibility (22.1%) and 5 (0.9%) women with active infection. Found no significant association between toxoplasmosis susceptibility and age, location, income, education, sewerage, number of pregnancies and gestational age. Variables with significant association (p≤0.05) were seropositive pregnant women who are multiparous (p=0.036), living with dogs stuck at home (p=0.001), and consumption of raw kibbeh (p=0.036). The frequency of seropositivity of these infectious diseases of vertical transmission in pregnant women seen at antenatal care in the city of Caxias-MA is considered high, but are similar to those described in other regions of Brazil. Pregnant women who are multiparous who perform consumption of raw kibbeh and live with dogs that do not wobble on the street, had more chance of becoming infected with Toxoplasma gondii, thus guidance on primary prevention measures and quarterly serological monitoring should be strengthened these infections of pregnant women, since it is important to identify and/or prevent congenital infection measured.A transmissão vertical das infecções da mãe para o filho e pode aumentar a morbimortalidade do binômio mãe-filho. Quando não diagnosticadas e tratadas adequamente, e ocasionam um sério problema de saúde pública. Este estudo objetivou estimar a soroprevalência de anticorpos para toxoplasmose, rubéola, citomegalovírus, hepatite B, sífilis e HIV entre gestantes em Caxias, Maranhão, Brasil e identificar os principais fatores associados à soropositividade para o Toxoplasma gondii (T. gondii) em gestantes atendidas em dois centros de referência em Caxias–MA. Estudo descritivo, observacional, transversal, com 561 gestantes que realizaram a assistência pré-natal em dois ambulatórios de referência para pré-natal de alto risco, no período de julho de 2011 a dezembro de 2012, nos ambulatórios da Maternidade Carmosina Coutinho (MCC) e no Centro Especializado de Assistência Materno-Infantil (CEAMI). Os testes sorológicos de toxoplasmose, rubéola, citomegalovírus, hepatite B foram realizados por um laboratório conveniado ao município, e para sífilis e HIV foram realizadas no laboratório do Centro de Testagem e Aconselhamento (CTA) do município. Uma amostra de sangue total das cinco gestantes IGM reagente para o T. gondii e de seus respectivos recém-nascidos foi processada no Instituto de Patologia Tropical e Saúde Publica da UFG no Setor de Parasitologia para a realização de Reação em Cadeia da Polimerase (PCR). A análise estatística foi realizada com o programa SPSS versão 20.0 Windows, usando os testes de associação qui-quadrado e Odds Ratio (IC95%), considerando-se o nível de significância de 5%. Constatou-se que a soropositividade para HIV foi de 0,4%, sífilis 2,0%, rubéola e citomegalovírus a reatividade de IgG foram de 93,6% e 87,8% respectivamente sem IgM reativa, HBsAg foi não reagente para todas as gestantes da amostra. Em relação ao T. gondii 437 (77,9%) foram soropositivas, a susceptibilidade em 124 (22,1%) e 5 (0,9%) gestantes com infecção ativa. Não foi observada associação significativa entre soropositividade para toxoplasmose e idade, procedência, renda, escolaridade, rede de esgotos, número de gestações e idade gestacional. As variáveis com associação significativa (p≤0,05) para soropositividade foram gestantes que são multigestas (p=0,036), convívio com cães presos em casa (p=0,001), e consumo de quibe cru (p=0,036). A frequência de soropositividade dessas doenças infecciosas de transmissão vertical em gestantes atendidas no pré-natal, no município de Caxias-MA é considerada alta, mas encontram-se semelhantes aos descritos em outras regiões do Brasil. As gestantes que são multigestas que realizam consumo de quibe cru e convivem com cães presos em casa, apresentaram mais chance de se infectar com o Toxoplasma gondii, assim, deve ser reforçada orientações sobre medidas de prevenção primária e o monitoramento sorológico trimestral dessas infecções às gestantes, uma vez que são medidas importantes para identificar e/ou prevenir as infecções congênitas.Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-03-24T17:25:34Z No. of bitstreams: 2 Tese - Joseneide Teixeira Câmara - 2014.pdf: 2654661 bytes, checksum: 45d6b37146cb1b9be595aa54c97b9a6a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-03-24T17:27:34Z (GMT) No. of bitstreams: 2 Tese - Joseneide Teixeira Câmara - 2014.pdf: 2654661 bytes, checksum: 45d6b37146cb1b9be595aa54c97b9a6a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-03-24T17:27:34Z (GMT). No. of bitstreams: 2 Tese - Joseneide Teixeira Câmara - 2014.pdf: 2654661 bytes, checksum: 45d6b37146cb1b9be595aa54c97b9a6a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2014-05-30Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://repositorio.bc.ufg.br/tede/retrieve/18227/Tese%20-%20Joseneide%20Teixeira%20C%c3%a2mara%20-%202014.pdf.jpgporUniversidade Federal de GoiásPrograma de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessEstudos soroepidemiológicosGravidezCuidado pré-natalTransmissão vertical de doença infecciosaToxoplasmoseToxoplasmosisSeroepidemiologic studiesPregnancyPrenatal careInfectious disease vertical transmissionCIENCIAS BIOLOGICAS::PARASITOLOGIAPrevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, MaranhãoPrevalence of infection of vertical transmission: toxoplasmosis, rubella, hepatitis B, syphilis, and cytomegalovirus infection by human immunodeficiency virus in pregnant women in Caxias, Maranhãoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis6085308344741430434600600600600-7769011444564556288-45445767472715743062075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão |
dc.title.alternative.eng.fl_str_mv |
Prevalence of infection of vertical transmission: toxoplasmosis, rubella, hepatitis B, syphilis, and cytomegalovirus infection by human immunodeficiency virus in pregnant women in Caxias, Maranhão |
title |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão |
spellingShingle |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão Câmara, Joseneide Teixeira Estudos soroepidemiológicos Gravidez Cuidado pré-natal Transmissão vertical de doença infecciosa Toxoplasmose Toxoplasmosis Seroepidemiologic studies Pregnancy Prenatal care Infectious disease vertical transmission CIENCIAS BIOLOGICAS::PARASITOLOGIA |
title_short |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão |
title_full |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão |
title_fullStr |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão |
title_full_unstemmed |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão |
title_sort |
Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão |
author |
Câmara, Joseneide Teixeira |
author_facet |
Câmara, Joseneide Teixeira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Castro, Ana Maria de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9232309971000621 |
dc.contributor.referee1.fl_str_mv |
Castro, Ana Maria de |
dc.contributor.referee2.fl_str_mv |
Vinaud, Marina Clare |
dc.contributor.referee3.fl_str_mv |
Araújo, Telma Maria Evangelista de |
dc.contributor.referee4.fl_str_mv |
Campelo, Viriato |
dc.contributor.referee5.fl_str_mv |
Pinheiro, Valéria Cristina Soares |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5718882034193418 |
dc.contributor.author.fl_str_mv |
Câmara, Joseneide Teixeira |
contributor_str_mv |
Castro, Ana Maria de Castro, Ana Maria de Vinaud, Marina Clare Araújo, Telma Maria Evangelista de Campelo, Viriato Pinheiro, Valéria Cristina Soares |
dc.subject.por.fl_str_mv |
Estudos soroepidemiológicos Gravidez Cuidado pré-natal Transmissão vertical de doença infecciosa Toxoplasmose |
topic |
Estudos soroepidemiológicos Gravidez Cuidado pré-natal Transmissão vertical de doença infecciosa Toxoplasmose Toxoplasmosis Seroepidemiologic studies Pregnancy Prenatal care Infectious disease vertical transmission CIENCIAS BIOLOGICAS::PARASITOLOGIA |
dc.subject.eng.fl_str_mv |
Toxoplasmosis Seroepidemiologic studies Pregnancy Prenatal care Infectious disease vertical transmission |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::PARASITOLOGIA |
description |
The vertical transmission of infection from mother to child, and may increase morbidity and mortality of both mother and child, when not diagnosed and by suitably dealest, causing a serious public health problem. This study aimed to estimate the prevalence of antibodies to toxoplasmosis, rubella, cytomegalovirus, hepatitis B, syphilis and HIV among pregnant women in Caxias, Maranhão, Brazil and identify the main factors associated with seropositivity for Toxoplasma gondii infection in pregnant women attending two referral centers Caxias, MA. Descriptive, observational, cross-sectional study of 561 pregnant women who received prenatal care at two clinics reference to prenatal high risk in the period July 2011 to December 2012, the outpatient clinics of Maternity Carmosina Coutinho (MCC) and the Specialized Center for Maternal and Child Care (CEAMI). Serological tests for toxoplasmosis, rubella, cytomegalovirus, hepatitis B were performed by a laboratory conveniado to the municipality by the same trained technician, and for syphilis and HIV were performed in the Counseling and Testing Center (ATC) in the city laboratory. And a small sample of whole blood from five pregnant IGM reagent for Toxoplasma gondii and their respective newborns was processed at the Institute of Tropical Pathology and Public Health in the Department of Parasitology UFG for performing Polymerase Chain Reaction (PCR). Statistical analysis was performed using SPSS version 20.0 Windows, using the chi-square tests of association and Odds Ratio (95%CI), considering a significance level of 5%. It was found to be positive for HIV was 0.4%, 2.0% syphilis, rubella and cytomegalovirus IgG reactivity were 93.6% and 87.8% respectively without reactive IgM, HBsAg was negative for all pregnant women in the sample tested. Regarding toxoplasmosis in 437 (77%), 124 susceptibility (22.1%) and 5 (0.9%) women with active infection. Found no significant association between toxoplasmosis susceptibility and age, location, income, education, sewerage, number of pregnancies and gestational age. Variables with significant association (p≤0.05) were seropositive pregnant women who are multiparous (p=0.036), living with dogs stuck at home (p=0.001), and consumption of raw kibbeh (p=0.036). The frequency of seropositivity of these infectious diseases of vertical transmission in pregnant women seen at antenatal care in the city of Caxias-MA is considered high, but are similar to those described in other regions of Brazil. Pregnant women who are multiparous who perform consumption of raw kibbeh and live with dogs that do not wobble on the street, had more chance of becoming infected with Toxoplasma gondii, thus guidance on primary prevention measures and quarterly serological monitoring should be strengthened these infections of pregnant women, since it is important to identify and/or prevent congenital infection measured. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-05-30 |
dc.date.accessioned.fl_str_mv |
2015-03-24T17:27:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CÂMARA, Joseneide Teixeira. Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão. 2014. 168 f. Tese (Doutorado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4342 |
dc.identifier.dark.fl_str_mv |
ark:/38995/0013000003k97 |
identifier_str_mv |
CÂMARA, Joseneide Teixeira. Prevalência de infecções de transmissão vertical: toxoplasmose, rubéola, hepatite B, sífilis, infecção pelo citomegalovirus e pelo vírus da imunodeficiência humana em gestantes atendidas em Caxias, Maranhão. 2014. 168 f. Tese (Doutorado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2014. ark:/38995/0013000003k97 |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4342 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6085308344741430434 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
-4544576747271574306 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
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UFG |
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UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
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Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
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tasesdissertacoes.bc@ufg.br |
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1815172547387326464 |