WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS

Detalhes bibliográficos
Autor(a) principal: Chaves, Nilo Sérgio Troncoso
Data de Publicação: 2007
Outros Autores: Barros, Paulo Sérgio de Moraes, Martins, Apóstolo Ferreira, Araújo, Eugênio Gonçalves de, Araújo, Larissa Franco de, Eurides, Duvaldo, Jacomini, Clausmir Zanetti
Tipo de documento: Artigo
Idioma: por
Título da fonte: Pesquisa Agropecuária Tropical (Online)
Texto Completo: https://revistas.ufg.br/pat/article/view/2933
Resumo: Ten mixed breed dogs, with a 10 kg average weight were selected at Centro de Zoonoses de Goiânia. After being examined and considered healthy, the dogs were enumerated from 11 to 20 on their collars. Each animal had swine cornea implanted into the left eye. The swine cornea was obtained at Casa de Banha Caçula, a slaughterhouse, and conserved in a humid chamber during a maximum 6 hour period. Each animal received 4 mg dissodic fosphate/acetate dexamethasone IM and was instilled one drop of gentamycin sulphate/betametbasone dissodic fosphate, maintaining ocular medication 4 times/day and intramuscular medication once a week until euthanasia. Each animal had blood samples collected on day 0, before surgery, and on day 14 and 28 to analyse white blood count as a monitor of corticosteroids, imunocellular supressor drugs. From ten blood samples collected on day 0, 80% didn’t present any alterations, 10% presented leukocytosis with neutrophilia and 10% weren’t submitted to analysis. Due to the fact that three animals had been euthanized between days 14 and 21, these samples (40%), were analyzed and compared with these collected on day 0. Five animals (50%) had their samples examined on day 28. On both days 14 and 28, there were 100% neutrophilia, 100% eosinophilia and 44.4% lymphocytopenia, indicating imunocellular supression. KEY-WORDS: Corticosteroids; xenotransplants; cornea; canine; swine.
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spelling WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGSESTUDO DO LEUCOGRAMA COMO MONITOR DO 2-1 FOSFATO DISSÓDICO DE BETAMETASONA DO FOSFATO DISSÓDICO/ACETATO DE DEXAMETASONA, EM CÃES QUE RECEBERAM TRANSPLANTES COM CÓRNEAS DE SUÍNOSCorticosteroidsxenotransplantscorneacanineswineCorticosteróidesxenotransplantescórneacaninosuíno Ten mixed breed dogs, with a 10 kg average weight were selected at Centro de Zoonoses de Goiânia. After being examined and considered healthy, the dogs were enumerated from 11 to 20 on their collars. Each animal had swine cornea implanted into the left eye. The swine cornea was obtained at Casa de Banha Caçula, a slaughterhouse, and conserved in a humid chamber during a maximum 6 hour period. Each animal received 4 mg dissodic fosphate/acetate dexamethasone IM and was instilled one drop of gentamycin sulphate/betametbasone dissodic fosphate, maintaining ocular medication 4 times/day and intramuscular medication once a week until euthanasia. Each animal had blood samples collected on day 0, before surgery, and on day 14 and 28 to analyse white blood count as a monitor of corticosteroids, imunocellular supressor drugs. From ten blood samples collected on day 0, 80% didn’t present any alterations, 10% presented leukocytosis with neutrophilia and 10% weren’t submitted to analysis. Due to the fact that three animals had been euthanized between days 14 and 21, these samples (40%), were analyzed and compared with these collected on day 0. Five animals (50%) had their samples examined on day 28. On both days 14 and 28, there were 100% neutrophilia, 100% eosinophilia and 44.4% lymphocytopenia, indicating imunocellular supression. KEY-WORDS: Corticosteroids; xenotransplants; cornea; canine; swine. Foram utilizados dez cães, sem raça definida, com peso médio de 10kg, selecionados no Centro de Zoonoses de Goiânia. Após serem examinados e considerados sadios, foram numerados de 11 a 20 na respectiva coleira. Cada animal, a seu tempo, teve implantada no olho esquerdo córnea de suíno, este abatido no frigorífico Casa de Banha Caçula. A córnea foi conservada em câmara úmida pelo período máximo de seis horas. Cada cão recebeu, antes da cirurgia, 4mg por via intramuscular de fosfato dissódico/acetato de dexametasona e uma gota de sulfato de gentamicina/fosfato dissódico de betametasona. Foi conservado o uso da medicação ocular 4 vezes/dia e a intramuscular semanalmente, até o sacrifício do cão. Cada animal teve uma amostra de sangue colhida no dia 0, antes da cirurgia, uma no 14° e outra no 28° dia, para o estudo do leucograma, como monitor dos corticosteróides. Nas dez amostras colhidas no dia 0, 80% não apresentaram alterações, já 10% apresentaram leucocitose com neutrofilia e 10% não foram analisadas. Como três animais foram sacrificados no intervalo do 14° ao 21° dia, estas amostras (40%), foram analisadas e comparadas com aquelas do tempo 0. Cinco animais (50%) tiveram suas amostras examinadas no 28° dia. Tanto no 14° como no 28° dia encontraram-se 100% de neutrofilia, 100% de eosinopenia e 44,4% de linfocitopenia, num sinal clássico de supressão imunocelular. PALAVRAS-CHAVE: Corticosteróides; xenotransplantes; córnea; canino; suíno.Escola de Agronomia - Universidade Federal de Goiás2007-12-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por paresapplication/pdfhttps://revistas.ufg.br/pat/article/view/2933Pesquisa Agropecuária Tropical [Agricultural Research in the Tropics]; v. 26, n. 2, Jul./Dec. 1996; 23-30Pesquisa Agropecuária Tropical (Agricultural Research in the Tropics); v. 26, n. 2, jul./dez. 1996; 23-30Pesquisa Agropecuária Tropical; v. 26, n. 2, jul./dez. 1996; 23-301983-4063reponame:Pesquisa Agropecuária Tropical (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporhttps://revistas.ufg.br/pat/article/view/2933/2980Chaves, Nilo Sérgio TroncosoBarros, Paulo Sérgio de MoraesMartins, Apóstolo FerreiraAraújo, Eugênio Gonçalves deAraújo, Larissa Franco deEurides, DuvaldoJacomini, Clausmir Zanettiinfo:eu-repo/semantics/openAccess2009-06-25T19:29:06Zoai:ojs.revistas.ufg.br:article/2933Revistahttps://revistas.ufg.br/patPUBhttps://revistas.ufg.br/pat/oaiaseleguini.pat@gmail.com||mgoes@agro.ufg.br1983-40631517-6398opendoar:2024-05-21T19:55:27.613155Pesquisa Agropecuária Tropical (Online) - Universidade Federal de Goiás (UFG)true
dc.title.none.fl_str_mv WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
ESTUDO DO LEUCOGRAMA COMO MONITOR DO 2-1 FOSFATO DISSÓDICO DE BETAMETASONA DO FOSFATO DISSÓDICO/ACETATO DE DEXAMETASONA, EM CÃES QUE RECEBERAM TRANSPLANTES COM CÓRNEAS DE SUÍNOS
title WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
spellingShingle WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
Chaves, Nilo Sérgio Troncoso
Corticosteroids
xenotransplants
cornea
canine
swine
Corticosteróides
xenotransplantes
córnea
canino
suíno
title_short WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
title_full WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
title_fullStr WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
title_full_unstemmed WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
title_sort WHITE BLOOD COUNT AS A 2-1 BETAMETHASONE DISSODIC FOSFHATE AND DEXAMETHASONE DISSODIC FOSPHATE/ACETATE MONITOR IN SWINE CORNEA TRANSPLANTED DOGS
author Chaves, Nilo Sérgio Troncoso
author_facet Chaves, Nilo Sérgio Troncoso
Barros, Paulo Sérgio de Moraes
Martins, Apóstolo Ferreira
Araújo, Eugênio Gonçalves de
Araújo, Larissa Franco de
Eurides, Duvaldo
Jacomini, Clausmir Zanetti
author_role author
author2 Barros, Paulo Sérgio de Moraes
Martins, Apóstolo Ferreira
Araújo, Eugênio Gonçalves de
Araújo, Larissa Franco de
Eurides, Duvaldo
Jacomini, Clausmir Zanetti
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chaves, Nilo Sérgio Troncoso
Barros, Paulo Sérgio de Moraes
Martins, Apóstolo Ferreira
Araújo, Eugênio Gonçalves de
Araújo, Larissa Franco de
Eurides, Duvaldo
Jacomini, Clausmir Zanetti
dc.subject.por.fl_str_mv Corticosteroids
xenotransplants
cornea
canine
swine
Corticosteróides
xenotransplantes
córnea
canino
suíno
topic Corticosteroids
xenotransplants
cornea
canine
swine
Corticosteróides
xenotransplantes
córnea
canino
suíno
description Ten mixed breed dogs, with a 10 kg average weight were selected at Centro de Zoonoses de Goiânia. After being examined and considered healthy, the dogs were enumerated from 11 to 20 on their collars. Each animal had swine cornea implanted into the left eye. The swine cornea was obtained at Casa de Banha Caçula, a slaughterhouse, and conserved in a humid chamber during a maximum 6 hour period. Each animal received 4 mg dissodic fosphate/acetate dexamethasone IM and was instilled one drop of gentamycin sulphate/betametbasone dissodic fosphate, maintaining ocular medication 4 times/day and intramuscular medication once a week until euthanasia. Each animal had blood samples collected on day 0, before surgery, and on day 14 and 28 to analyse white blood count as a monitor of corticosteroids, imunocellular supressor drugs. From ten blood samples collected on day 0, 80% didn’t present any alterations, 10% presented leukocytosis with neutrophilia and 10% weren’t submitted to analysis. Due to the fact that three animals had been euthanized between days 14 and 21, these samples (40%), were analyzed and compared with these collected on day 0. Five animals (50%) had their samples examined on day 28. On both days 14 and 28, there were 100% neutrophilia, 100% eosinophilia and 44.4% lymphocytopenia, indicating imunocellular supression. KEY-WORDS: Corticosteroids; xenotransplants; cornea; canine; swine.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.ufg.br/pat/article/view/2933
url https://revistas.ufg.br/pat/article/view/2933
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistas.ufg.br/pat/article/view/2933/2980
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Escola de Agronomia - Universidade Federal de Goiás
publisher.none.fl_str_mv Escola de Agronomia - Universidade Federal de Goiás
dc.source.none.fl_str_mv Pesquisa Agropecuária Tropical [Agricultural Research in the Tropics]; v. 26, n. 2, Jul./Dec. 1996; 23-30
Pesquisa Agropecuária Tropical (Agricultural Research in the Tropics); v. 26, n. 2, jul./dez. 1996; 23-30
Pesquisa Agropecuária Tropical; v. 26, n. 2, jul./dez. 1996; 23-30
1983-4063
reponame:Pesquisa Agropecuária Tropical (Online)
instname:Universidade Federal de Goiás (UFG)
instacron:UFG
instname_str Universidade Federal de Goiás (UFG)
instacron_str UFG
institution UFG
reponame_str Pesquisa Agropecuária Tropical (Online)
collection Pesquisa Agropecuária Tropical (Online)
repository.name.fl_str_mv Pesquisa Agropecuária Tropical (Online) - Universidade Federal de Goiás (UFG)
repository.mail.fl_str_mv aseleguini.pat@gmail.com||mgoes@agro.ufg.br
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