Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Ciência animal brasileira (Online) |
Texto Completo: | https://revistas.ufg.br/vet/article/view/63574 |
Resumo: | Conjugated linoleic acid (CLA) is a mixture of positional isomers of linoleic acid found in meat and dairy products from ruminants. It is a trans fat widely used by athletes as a food supplement, due to a supposed effect of maximizing the use of body fat reserves. The interest in diet and culture media supplementation with CLA is an emerging area, demanding studies in order to elucidate its benefits in the reproductive parameters, as well as in cryopreservation. Therefore, the aim of this review was to discuss the effects of CLA on the oocytes, sperm and embryos cryotolerance. Some studies have already demonstrated its use in cryopreservation of germline. Among those, it was observed that CLA supplementation during oocyte in vitro maturation can increase their viability post-freezing and developmental capacity. Regarding the use of CLA on sperm, there are few studies and their results are still inconclusive. Finally, studies about CLA supplementation on embryo culture media have shown promising results, indicating that this bioactive molecule is able to modulate lipid uptake on blastomeres. Altogether, these findings demonstrate the potential use of CLA as a bioactive molecule to improve germline and embryo cryotolerance and open new perspectives on human and animal reproduction field.Keywords: lipid accumulation, cryopreservation, embryo, oocyte, sperm. |
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Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotoleranceÁcido linoleico conjugado como potencial bioativo para modulação e criotolerância de gametas e embriõesConjugated linoleic acid (CLA) is a mixture of positional isomers of linoleic acid found in meat and dairy products from ruminants. It is a trans fat widely used by athletes as a food supplement, due to a supposed effect of maximizing the use of body fat reserves. The interest in diet and culture media supplementation with CLA is an emerging area, demanding studies in order to elucidate its benefits in the reproductive parameters, as well as in cryopreservation. Therefore, the aim of this review was to discuss the effects of CLA on the oocytes, sperm and embryos cryotolerance. Some studies have already demonstrated its use in cryopreservation of germline. Among those, it was observed that CLA supplementation during oocyte in vitro maturation can increase their viability post-freezing and developmental capacity. Regarding the use of CLA on sperm, there are few studies and their results are still inconclusive. Finally, studies about CLA supplementation on embryo culture media have shown promising results, indicating that this bioactive molecule is able to modulate lipid uptake on blastomeres. Altogether, these findings demonstrate the potential use of CLA as a bioactive molecule to improve germline and embryo cryotolerance and open new perspectives on human and animal reproduction field.Keywords: lipid accumulation, cryopreservation, embryo, oocyte, sperm.O ácido linoleico conjugado (CLA) é uma mistura de isômeros posicionais do ácido linoleico encontrado em carne e laticínios de ruminantes. É um tipo de gordura trans muito utilizada por atletas para como suplemento alimentar devido a um suposto efeito de maximizar a utilização das reservas de gordura corporal. O interesse na suplementação de dietas e meios de cultura com o CLA é uma área emergente, exigindo estudos para elucidar seus benefícios nos parâmetros reprodutivos e na criopreservação. Dessa forma, o objetivo dessa revisão foi discutir os efeitos do CLA na criotolerância de oócitos, espermatozóides e embriões. Alguns estudos já demonstraram seu uso na criopreservação da linhagem germinativa. Entre esses, foi observado que a suplementação de CLA durante a maturação in vitro de oócitos pode aumentar sua viabilidade pós-congelamento e capacidade de desenvolvimento. Em relação ao uso de CLA no esperma, existem poucos estudos e seus resultados ainda são inconclusivos. Por último, estudos sobre a suplementação de CLA em meios de cultura de embriões mostraram resultados promissores, indicando que essa molécula bioativa é capaz de modular a captação de lipídios em blastômeros. No total, essas descobertas demonstram o potencial uso do CLA como uma molécula bioativa para melhorar a linha germinativa e a criotolerância ao embrião e abrir novas perspectivas no campo da reprodução humana e animal.Palavras-chave: acúmulo lipídico, criopreservação, embrião, oócito, sêmen.Universidade Federal de Goiás2020-10-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlapplication/pdftext/htmlhttps://revistas.ufg.br/vet/article/view/63574Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 21 (2020): Continuous publicationCiência Animal Brasileira / Brazilian Animal Science; v. 21 (2020): Publicação contínua1809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporenghttps://revistas.ufg.br/vet/article/view/63574/35591https://revistas.ufg.br/vet/article/view/63574/35592https://revistas.ufg.br/vet/article/view/63574/35593https://revistas.ufg.br/vet/article/view/63574/35594Copyright (c) 2020 Ciência Animal Brasileirainfo:eu-repo/semantics/openAccessFreitas, Danielle StorinoLopes, Guilherme Antonio de GouvêaNascimento, Barbara RodriguesPereira, Luiza Aparecida Ansaloni ChagasBatista, Ribrio Ivan Tavares PereiraAlmeida Campos Junior, Paulo Henrique2023-03-23T18:46:38Zoai:ojs.revistas.ufg.br:article/63574Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2024-05-21T19:56:26.570892Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)true |
dc.title.none.fl_str_mv |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance Ácido linoleico conjugado como potencial bioativo para modulação e criotolerância de gametas e embriões |
title |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance |
spellingShingle |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance Freitas, Danielle Storino |
title_short |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance |
title_full |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance |
title_fullStr |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance |
title_full_unstemmed |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance |
title_sort |
Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance |
author |
Freitas, Danielle Storino |
author_facet |
Freitas, Danielle Storino Lopes, Guilherme Antonio de Gouvêa Nascimento, Barbara Rodrigues Pereira, Luiza Aparecida Ansaloni Chagas Batista, Ribrio Ivan Tavares Pereira Almeida Campos Junior, Paulo Henrique |
author_role |
author |
author2 |
Lopes, Guilherme Antonio de Gouvêa Nascimento, Barbara Rodrigues Pereira, Luiza Aparecida Ansaloni Chagas Batista, Ribrio Ivan Tavares Pereira Almeida Campos Junior, Paulo Henrique |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Freitas, Danielle Storino Lopes, Guilherme Antonio de Gouvêa Nascimento, Barbara Rodrigues Pereira, Luiza Aparecida Ansaloni Chagas Batista, Ribrio Ivan Tavares Pereira Almeida Campos Junior, Paulo Henrique |
description |
Conjugated linoleic acid (CLA) is a mixture of positional isomers of linoleic acid found in meat and dairy products from ruminants. It is a trans fat widely used by athletes as a food supplement, due to a supposed effect of maximizing the use of body fat reserves. The interest in diet and culture media supplementation with CLA is an emerging area, demanding studies in order to elucidate its benefits in the reproductive parameters, as well as in cryopreservation. Therefore, the aim of this review was to discuss the effects of CLA on the oocytes, sperm and embryos cryotolerance. Some studies have already demonstrated its use in cryopreservation of germline. Among those, it was observed that CLA supplementation during oocyte in vitro maturation can increase their viability post-freezing and developmental capacity. Regarding the use of CLA on sperm, there are few studies and their results are still inconclusive. Finally, studies about CLA supplementation on embryo culture media have shown promising results, indicating that this bioactive molecule is able to modulate lipid uptake on blastomeres. Altogether, these findings demonstrate the potential use of CLA as a bioactive molecule to improve germline and embryo cryotolerance and open new perspectives on human and animal reproduction field.Keywords: lipid accumulation, cryopreservation, embryo, oocyte, sperm. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistas.ufg.br/vet/article/view/63574 |
url |
https://revistas.ufg.br/vet/article/view/63574 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://revistas.ufg.br/vet/article/view/63574/35591 https://revistas.ufg.br/vet/article/view/63574/35592 https://revistas.ufg.br/vet/article/view/63574/35593 https://revistas.ufg.br/vet/article/view/63574/35594 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Ciência Animal Brasileira info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Ciência Animal Brasileira |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html application/pdf text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 21 (2020): Continuous publication Ciência Animal Brasileira / Brazilian Animal Science; v. 21 (2020): Publicação contínua 1809-6891 1518-2797 reponame:Ciência animal brasileira (Online) instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Ciência animal brasileira (Online) |
collection |
Ciência animal brasileira (Online) |
repository.name.fl_str_mv |
Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
||revistacab@gmail.com |
_version_ |
1799874790480150528 |