SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS

Detalhes bibliográficos
Autor(a) principal: Garcia, Sérgio Diniz
Data de Publicação: 2009
Outros Autores: Perri, Silvia Helena Venturoli, Chierice, Gilberto, Cardoso, Daniel
Tipo de documento: Artigo
Idioma: por
Título da fonte: Ciência animal brasileira (Online)
Texto Completo: https://revistas.ufg.br/vet/article/view/1660
Resumo: Castor oil polymer is a biomaterial that can be used to fill bone defects. Biomaterials should present some characteristics such as: biocompatibility, inert, absence of toxin radical and vapour discharge and permit the organism to recognize them as a part of their structure. The aim of this study was to investigate changes in water ingestion, feed intake, weight gain and toxic effects in rats (Rattus norvegicus) after ingestion of 0, 10, 25 and 50% of castor oil polymer (COP, Ricinus communis). In groups that received 10 and 25% of COP the weight gain was smaller than the control group. Feed intake in control group was greater than in groups 10 and 50% COP. The intake of castor oil polymer reduced feed intake and water ingest probably because of the palatability of the product. In the second part of this study (multigenerational) there were no toxic effects in the offspring, as external birth defects or alterations incompatible with life, in spite of the fact that lower weight were observed in males and females of the second generation. KEY WORDS: Biomaterials, bone defects, polymer, Ricinus communis.
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spelling SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATSAVALIAÇÃO DA TOXICIDADE SUBAGUDA E MULTIGERACIONAL DA INGESTÃO DE DERIVADO DO POLÍMERO DE MAMONA EM RATOSToxicologiaCastor oil polymer is a biomaterial that can be used to fill bone defects. Biomaterials should present some characteristics such as: biocompatibility, inert, absence of toxin radical and vapour discharge and permit the organism to recognize them as a part of their structure. The aim of this study was to investigate changes in water ingestion, feed intake, weight gain and toxic effects in rats (Rattus norvegicus) after ingestion of 0, 10, 25 and 50% of castor oil polymer (COP, Ricinus communis). In groups that received 10 and 25% of COP the weight gain was smaller than the control group. Feed intake in control group was greater than in groups 10 and 50% COP. The intake of castor oil polymer reduced feed intake and water ingest probably because of the palatability of the product. In the second part of this study (multigenerational) there were no toxic effects in the offspring, as external birth defects or alterations incompatible with life, in spite of the fact that lower weight were observed in males and females of the second generation. KEY WORDS: Biomaterials, bone defects, polymer, Ricinus communis.Os biomateriais são polímeros artificiais desenvolvidos para substituir tecidos orgânicos danificados e preencherem falhas ósseas. Eles devem apresentar características como a biocompatibilidade, serem inertes, não liberarem vapores e radicais tóxicos e permitirem ao organismo reconhecê-los como parte de sua estrutura. Procurou-se determinar a ingestão de água, o consumo de ração, ganho de peso e possível efeito tóxico decorrentes da ingestão de três doses (10%, 25% e 50%) do derivado do polímero de mamona (PM, Ricinus communis), adicionado à água de bebida, em ratos (Rattus norvegicus). Nos grupos que receberam 10% e 25% do PM, o ganho de peso foi menor (P?0,05), quando comparado ao grupo-controle. O consumo de ração nos grupos que receberam 10% e 50% de PM foi menor em relação ao grupo-controle. A ingestão do polímero de mamona reduziu a ingestão de ração e o ganho de peso, provavelmente relacionado à palatabilidade do produto. Numa segunda fase experimental (estudo multigeracional) não se verificaram efeitos tóxicos, nas proles, como má formação externa e alterações incompatíveis com a vida, apesar de ter havido redução no peso dos machos e das fêmeas da segunda geração.PALAVRAS-CHAVES: Biomateriais, falhas ósseas, polímeros, Ricinus communis.Universidade Federal de Goiás2009-04-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por paresPesquisa Científicaapplication/pdfhttps://revistas.ufg.br/vet/article/view/166010.5216/cab.v10i1.1660Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 10 No. 1 (2009); 219-225Ciência Animal Brasileira / Brazilian Animal Science; v. 10 n. 1 (2009); 219-2251809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporhttps://revistas.ufg.br/vet/article/view/1660/4588Garcia, Sérgio DinizPerri, Silvia Helena VenturoliChierice, GilbertoCardoso, Danielinfo:eu-repo/semantics/openAccess2013-10-31T10:44:12Zoai:ojs.revistas.ufg.br:article/1660Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2013-10-31T10:44:12Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)false
dc.title.none.fl_str_mv SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
AVALIAÇÃO DA TOXICIDADE SUBAGUDA E MULTIGERACIONAL DA INGESTÃO DE DERIVADO DO POLÍMERO DE MAMONA EM RATOS
title SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
spellingShingle SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
Garcia, Sérgio Diniz
Toxicologia
title_short SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
title_full SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
title_fullStr SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
title_full_unstemmed SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
title_sort SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS
author Garcia, Sérgio Diniz
author_facet Garcia, Sérgio Diniz
Perri, Silvia Helena Venturoli
Chierice, Gilberto
Cardoso, Daniel
author_role author
author2 Perri, Silvia Helena Venturoli
Chierice, Gilberto
Cardoso, Daniel
author2_role author
author
author
dc.contributor.author.fl_str_mv Garcia, Sérgio Diniz
Perri, Silvia Helena Venturoli
Chierice, Gilberto
Cardoso, Daniel
dc.subject.por.fl_str_mv Toxicologia
topic Toxicologia
description Castor oil polymer is a biomaterial that can be used to fill bone defects. Biomaterials should present some characteristics such as: biocompatibility, inert, absence of toxin radical and vapour discharge and permit the organism to recognize them as a part of their structure. The aim of this study was to investigate changes in water ingestion, feed intake, weight gain and toxic effects in rats (Rattus norvegicus) after ingestion of 0, 10, 25 and 50% of castor oil polymer (COP, Ricinus communis). In groups that received 10 and 25% of COP the weight gain was smaller than the control group. Feed intake in control group was greater than in groups 10 and 50% COP. The intake of castor oil polymer reduced feed intake and water ingest probably because of the palatability of the product. In the second part of this study (multigenerational) there were no toxic effects in the offspring, as external birth defects or alterations incompatible with life, in spite of the fact that lower weight were observed in males and females of the second generation. KEY WORDS: Biomaterials, bone defects, polymer, Ricinus communis.
publishDate 2009
dc.date.none.fl_str_mv 2009-04-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por pares
Pesquisa Científica
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.ufg.br/vet/article/view/1660
10.5216/cab.v10i1.1660
url https://revistas.ufg.br/vet/article/view/1660
identifier_str_mv 10.5216/cab.v10i1.1660
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistas.ufg.br/vet/article/view/1660/4588
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Goiás
publisher.none.fl_str_mv Universidade Federal de Goiás
dc.source.none.fl_str_mv Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 10 No. 1 (2009); 219-225
Ciência Animal Brasileira / Brazilian Animal Science; v. 10 n. 1 (2009); 219-225
1809-6891
1518-2797
reponame:Ciência animal brasileira (Online)
instname:Universidade Federal de Goiás (UFG)
instacron:UFG
instname_str Universidade Federal de Goiás (UFG)
instacron_str UFG
institution UFG
reponame_str Ciência animal brasileira (Online)
collection Ciência animal brasileira (Online)
repository.name.fl_str_mv Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)
repository.mail.fl_str_mv ||revistacab@gmail.com
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