A pneumonia outbreak associated with a new coronavirus of probable bat origin

• Autor(a) principal: Zhou, Peng
• Data de Publicação: 2020
• Outros Autores: Yang, Xing-Lou, Wang, Xian-Guang, Hu, Ben, Zhang, Lei, Zhang, Wei, Si, Hao-Rui, Zhu, Yan, Li, Bei, Huang, Chao-Lin, Chen, Hui-Dong, Chen, Jing, Luo, Yun, Guo, Hua, Jiang, Ren-Di, Liu, Mei-Qin, Chen, Ying, Shen, Xu-Rui, Wang, Xi, Zheng, Xiao-Shuang, Zhao, Kai, Chen, Quan-Jiao, Deng, Fei, Liu, Lin-Lin, Yan, Bing, Zhan, Fa-Xian, Wang, Yan-Yi, Xiao, Geng-Fu, Shi, Zheng-Li
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFLA
• Texto Completo: http://repositorio.ufla.br/jspui/handle/1/39411
• topic: Coronavirus; Severe acute respiratory syndrome; Pathogenic virus; Síndrome respiratória aguda grave; Vírus patogênicos

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.