Peroxoniobium inhibits leukemia cell growth

Detalhes bibliográficos
Autor(a) principal: Pereira-Maia, Elene C.
Data de Publicação: 2018
Outros Autores: Souza, Ivina P., Nunes, Kelen J. R. C., Castro, Alexandre A., Ramalho, Teodorico C., Steffler, Fernando, Duarte, Helio A., Pacheli, Ana, Chagas, Poliana, Oliveira, Luiz C. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/35319
Resumo: A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.
id UFLA_66c34eaa37b62761691000628214ef71
oai_identifier_str oai:localhost:1/35319
network_acronym_str UFLA
network_name_str Repositório Institucional da UFLA
repository_id_str
spelling Peroxoniobium inhibits leukemia cell growthPolyoxoniobate complexAnticancer agentPhotodynamic therapyA new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.Royal Society of Chemistry (RSC)2019-07-16T11:50:53Z2019-07-16T11:50:53Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPEREIRA-MAIA, E. C. et al. Peroxoniobium inhibits leukemia cell growth. RSC Advances, [S.l.], v. 8, n. 19, p. 10310-10313, 2018. DOI: 10.1039/c8ra00898a.http://repositorio.ufla.br/jspui/handle/1/35319RSC Advancesreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessPereira-Maia, Elene C.Souza, Ivina P.Nunes, Kelen J. R. C.Castro, Alexandre A.Ramalho, Teodorico C.Steffler, FernandoDuarte, Helio A.Pacheli, AnaChagas, PolianaOliveira, Luiz C. A.eng2019-07-16T11:52:07Zoai:localhost:1/35319Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2019-07-16T11:52:07Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Peroxoniobium inhibits leukemia cell growth
title Peroxoniobium inhibits leukemia cell growth
spellingShingle Peroxoniobium inhibits leukemia cell growth
Pereira-Maia, Elene C.
Polyoxoniobate complex
Anticancer agent
Photodynamic therapy
title_short Peroxoniobium inhibits leukemia cell growth
title_full Peroxoniobium inhibits leukemia cell growth
title_fullStr Peroxoniobium inhibits leukemia cell growth
title_full_unstemmed Peroxoniobium inhibits leukemia cell growth
title_sort Peroxoniobium inhibits leukemia cell growth
author Pereira-Maia, Elene C.
author_facet Pereira-Maia, Elene C.
Souza, Ivina P.
Nunes, Kelen J. R. C.
Castro, Alexandre A.
Ramalho, Teodorico C.
Steffler, Fernando
Duarte, Helio A.
Pacheli, Ana
Chagas, Poliana
Oliveira, Luiz C. A.
author_role author
author2 Souza, Ivina P.
Nunes, Kelen J. R. C.
Castro, Alexandre A.
Ramalho, Teodorico C.
Steffler, Fernando
Duarte, Helio A.
Pacheli, Ana
Chagas, Poliana
Oliveira, Luiz C. A.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira-Maia, Elene C.
Souza, Ivina P.
Nunes, Kelen J. R. C.
Castro, Alexandre A.
Ramalho, Teodorico C.
Steffler, Fernando
Duarte, Helio A.
Pacheli, Ana
Chagas, Poliana
Oliveira, Luiz C. A.
dc.subject.por.fl_str_mv Polyoxoniobate complex
Anticancer agent
Photodynamic therapy
topic Polyoxoniobate complex
Anticancer agent
Photodynamic therapy
description A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019-07-16T11:50:53Z
2019-07-16T11:50:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PEREIRA-MAIA, E. C. et al. Peroxoniobium inhibits leukemia cell growth. RSC Advances, [S.l.], v. 8, n. 19, p. 10310-10313, 2018. DOI: 10.1039/c8ra00898a.
http://repositorio.ufla.br/jspui/handle/1/35319
identifier_str_mv PEREIRA-MAIA, E. C. et al. Peroxoniobium inhibits leukemia cell growth. RSC Advances, [S.l.], v. 8, n. 19, p. 10310-10313, 2018. DOI: 10.1039/c8ra00898a.
url http://repositorio.ufla.br/jspui/handle/1/35319
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
dc.source.none.fl_str_mv RSC Advances
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
_version_ 1807835138852126720

Registros relacionados